Abstract:
:Renal sympathetic efferent and afferent nerves, which lie within and immediately adjacent to the wall of the renal arteries, contribute to the maintenance of hypertension. Because the causative factors of hypertension change over time, denervation of both efferent and afferent renal nerves should result in long-term attenuation of hypertension. The importance of the renal nerves in hypertensive patients can now be defined with the novel development of percutaneous, minimally invasive renal denervation from within the renal artery using radiofrequency energy as a therapeutic strategy. Studies thus far show that catheter-based renal denervation in patients with resistant essential hypertension lowers systolic blood pressure 27 mm Hg by 12 months, with the estimated glomerular filtration rate remaining stable. The decrease in arterial pressure after renal denervation is associated with decreased peripheral sympathetic nervous system activity, suggesting that the kidney is a source of significant central sympathetic outflow via afferent renal nerve activity.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Katholi RE,Rocha-Singh KJ,Goswami NJ,Sobotka PAdoi
10.1007/s11906-010-0108-4subject
Has Abstractpub_date
2010-06-01 00:00:00pages
196-204issue
3eissn
1522-6417issn
1534-3111journal_volume
12pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2018-04-10 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2000-04-01 00:00:00
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journal_title:Current hypertension reports
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00