Abstract:
PURPOSE OF REVIEW:The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of this review is to describe recent discoveries regarding the roles of intrarenal ACE and ACE2 and their interaction. RECENT FINDINGS:Renal tubular ACE contributes to salt-sensitive hypertension. Additionally, the relative expression and activity of intrarenal ACE and ACE2 are central to promoting or inhibiting different renal pathologies including renovascular hypertension, diabetic nephropathy, and renal fibrosis. Renal ACE and ACE2 represent two opposing axes within the intrarenal RAS system whose interaction determines the progression of several common disease processes. While this relationship remains complex and incompletely understood, further investigations hold the potential for creating novel approaches to treating hypertension and kidney disease.
journal_name
Curr Hypertens Repjournal_title
Current hypertension reportsauthors
Culver S,Li C,Siragy HMdoi
10.1007/s11906-017-0778-2subject
Has Abstractpub_date
2017-09-19 00:00:00pages
80issue
10eissn
1522-6417issn
1534-3111pii
10.1007/s11906-017-0778-2journal_volume
19pub_type
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