Development of a sialic acid-containing hydrogel of poly[N-(2-hydroxypropyl) methacrylamide]: characterization and implantation study.

abstract：:Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

journal_title：Biomacromolecules

authors： He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

更新日期：2015-04-13 00:00:00

abstract：:The new combinations of monomers presented in this work were evaluated in order to create an elastic material for potential application in soft tissue engineering. Thermoplastic elastomers (TPE) of trimethylene carbonate (TMC) with L-lactide (LLA) and 1,5-dioxepan-2-one (DXO) have been synthesized using a cyclic five-...

journal_title：Biomacromolecules

authors： Andronova N,Albertsson AC

更新日期：2006-05-01 00:00:00

abstract：:A poly[(R)-3-hydroxybutyrate] (P(3HB))-degrading marine bacterium (strain NK-1, JCM10458) was isolated from the Pacific Ocean deep-sea floor (1165 m in depth) in Japan. The organism was a motile and Gram negative, aerobic, and rod-shaped bacterium, and its DNA had a guanine-plus-cytosine content of 57.7 mol%. On the b...

journal_title：Biomacromolecules

authors： Kasuya K,Mitomo H,Nakahara M,Akiba A,Kudo T,Doi Y

更新日期：2000-07-01 00:00:00

abstract：:The main objective of the present work was the development of new nanoparticulate carrier systems for the delivery of plasmid DNA. These new carriers consist of a blend matrix formed by a poly(lactic-co-glycolic acid) (PLGA) copolymer and polyoxyethylene derivatives. More specifically, we have prepared nanostructures ...

journal_title：Biomacromolecules

authors： Csaba N,Caamaño P,Sánchez A,Domínguez F,Alonso MJ

更新日期：2005-01-01 00:00:00

abstract：:The Bacillus subtilis protease Proleather FG-F catalyzed the transesterification of inulin with vinyl acrylate (VA) in dimethylformamide (DMF). The reaction conversion for different VA concentrations was greater than 57% after 96 h at 50 degrees C. The degree of substitution (DS, defined as the amount of acrylate grou...

journal_title：Biomacromolecules

authors： Ferreira L,Carvalho R,Gil MH,Dordick JS

更新日期：2002-03-01 00:00:00

abstract：:Poly(ethylene glycol) (PEG) star polymers containing GRGDS (Gly-Arg-Gly-Asp-Ser) peptide sequences on the star periphery were synthesized by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate (PEGMA), GRGDS modified poly(ethylene glycol) acrylate (GRGDS-PEG-Acryl), fluoresce...

journal_title：Biomacromolecules

authors： Cho HY,Gao H,Srinivasan A,Hong J,Bencherif SA,Siegwart DJ,Paik HJ,Hollinger JO,Matyjaszewski K

更新日期：2010-09-13 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:Tumor targeting has revolutionized cancer research, especially active cellular targeting of nanoparticles, where they are specifically homed to the pathological site to deliver the therapeutics. This strategy, which involves the utilization of affinity ligands on the surface of the nanocarriers, minimizes the nonspeci...

journal_title：Biomacromolecules

authors： Raveendran R,Chen F,Kent B,Stenzel MH

更新日期：2020-03-09 00:00:00

abstract：:The conformational behavior of a long single-chain double-stranded DNA in solutions of free silver ions and silver nanoparticles generated via the reduction of AgNO3 by NaBH4 was monitored by fluorescence and electron microscopies and UV spectroscopy. The interaction of monovalent silver ions with DNA induces shrinkin...

journal_title：Biomacromolecules

authors： Zinchenko AA,Baigl D,Chen N,Pyshkina O,Endo K,Sergeyev VG,Yoshikawa K

更新日期：2008-07-01 00:00:00

abstract：:The adhesion of wet regenerated cellulose to colloidal complexes formed between carboxymethyl cellulose (CMC) and polyvinylamine (PVAm) was evaluated by measuring the force to delaminate pairs of regenerated cellulose membranes bound together with polyelectrolyte complex. The most important parameter was the surface c...

journal_title：Biomacromolecules

authors： Feng X,Pouw K,Leung V,Pelton R

更新日期：2007-07-01 00:00:00

abstract：:A novel pH and temperature sensitive block copolymer was prepared by adding pH sensitive moiety to temperature sensitive block copolymer. This block copolymer solution showed a reversible sol-gel transition by a small pH change in the range of pH 7.4-8.0 and also by the temperature change in the region of body tempera...

journal_title：Biomacromolecules

authors： Shim WS,Yoo JS,Bae YH,Lee DS

更新日期：2005-11-01 00:00:00

abstract：:Hydrogels constructed from folded protein domains are of increasing interest as resilient and responsive biomaterials, but their optimization for applications requires time-consuming and costly molecular design. Here, we explore a complementary approach to control their properties by examining the influence of crossli...

journal_title：Biomacromolecules

authors： Aufderhorst-Roberts A,Hughes MDG,Hare A,Head DA,Kapur N,Brockwell DJ,Dougan L

更新日期：2020-10-12 00:00:00

abstract：:We prepared statistical copolymers composed of 2-methyl-2-oxazoline (MeOx) in combination with 2-butenyl-2-oxazoline (BuOx) or 2-decenyl-2-oxazoline (DecOx) as a basis for polymer analogous introduction of 1,2-aminothiol moieties at the side chain. MeOx provides hydrophilicity as well as cyto- and hemocompatibility, w...

journal_title：Biomacromolecules

authors： Schmitz M,Kuhlmann M,Reimann O,Hackenberger CP,Groll J

更新日期：2015-04-13 00:00:00

abstract：:In this work, we have analyzed the structural, topographical, and surface dilatational characteristics of pure beta-lactoglobulin adsorbed films and the effect of the self-assembly of monoglycerides (monopalmitin or monoolein) in beta-lactoglobulin films at the air-water interface. Measurements were performed in a sin...

journal_title：Biomacromolecules

authors： Rodríguez Patino JM,Fernandez MC,Rodríguez Niño MR,Sanchez CC

更新日期：2006-09-01 00:00:00

abstract：:Disulfide bonds stabilize the tertiary- and quaternary structure of proteins. In addition, they can be used to engineer redox-sensitive (bio)materials and drug-delivery systems. Many of these applications require control of the stability of the disulfide bond. It has recently been shown that the charged microenvironme...

journal_title：Biomacromolecules

authors： Wu C,Wang S,Brülisauer L,Leroux JC,Gauthier MA

更新日期：2013-07-08 00:00:00

abstract：:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an appr...

journal_title：Biomacromolecules

authors： Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW

更新日期：2018-11-12 00:00:00

abstract：:Surface-immobilized liposome layers are of interest for various potential applications such as localized drug delivery, but their characterization is challenging. We have employed an AFM method and fluorescent dye release to analyze anchored liposomes. In addition, we studied whether the liposomes are surface-bound so...

journal_title：Biomacromolecules

authors： Vermette P,Griesser HJ,Kambouris P,Meagher L

更新日期：2004-07-01 00:00:00

abstract：:Surface modification is often needed in tissue engineering to enhance the interaction between cells and synthetic materials and improve the cytocompatibility and cellular functions. In this study, block copolymers of poly(L-lactic acid) and poly(ethyl ethylene phosphate) (PLLA-b-PEEP) were synthesized and used to modi...

journal_title：Biomacromolecules

authors： Yang XZ,Sun TM,Dou S,Wu J,Wang YC,Wang J

更新日期：2009-08-10 00:00:00

abstract：:An injectable, heparin-based hydrogel system with the potential to be gelled with cells was developed. First, heparin was modified to have thiol groups by the modification of carboxylic groups of heparin with cysteamine using carbodiimide chemistry. Thiol functionalization of heparin carboxylic groups was controlled f...

journal_title：Biomacromolecules

authors： Tae G,Kim YJ,Choi WI,Kim M,Stayton PS,Hoffman AS

更新日期：2007-06-01 00:00:00

abstract：:Molecular dynamics (MD) simulations have been applied to study the interactions between hydrophobic and hydrophilic faces of ordered cellulose chains and a single layer of graphene in explicit aqueous solvent. The hydrophobic cellulose face is predicted to form a stable complex with graphene. This interface remains so...

journal_title：Biomacromolecules

authors： Alqus R,Eichhorn SJ,Bryce RA

更新日期：2015-06-08 00:00:00

abstract：:We investigate the effects of mixing a colloidal suspension of tunicate-derived cellulose nanocrystals (t-CNCs) with aqueous colloidal suspensions of two protein diblock copolymers, EC and CE, which bear two different self-assembling domains (SADs) derived from elastin (E) and the coiled-coil region of cartilage oligo...

journal_title：Biomacromolecules

authors： Haghpanah JS,Tu R,Da Silva S,Yan D,Mueller S,Weder C,Foster EJ,Sacui I,Gilman JW,Montclare JK

更新日期：2013-12-09 00:00:00

abstract：:Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crys...

journal_title：Biomacromolecules

authors： Lin YH,Mi FL,Chen CT,Chang WC,Peng SF,Liang HF,Sung HW

更新日期：2007-01-01 00:00:00

abstract：:The encapsulation of live cells with polymeric coat-ings is a versatile approach to modulate or control the response cells to their environment. The layer-by-layer (LbL) self-assembly of nonimmunogenic polyelectrolytes is employed here to attenuate or suppress the binding of antibodies to live red blood cells (RBCs) a...

journal_title：Biomacromolecules

authors： Mansouri S,Merhi Y,Winnik FM,Tabrizian M

更新日期：2011-03-14 00:00:00

abstract：:As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...

journal_title：Biomacromolecules

authors： Zhao Y,Tanaka M,Kinoshita T,Higuchi M,Tan T

更新日期：2009-12-14 00:00:00

abstract：:Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG and hyaluronan, is co...

journal_title：Biomacromolecules

authors： McCall JD,Anseth KS

更新日期：2012-08-13 00:00:00

abstract：:Eosinophil cationic protein (ECP) is an antimicrobial protein belonging to the superfamily of RNase A. ECP exhibits a broad spectrum of action against bacteria and, at higher concentrations, displays cytotoxic activity to eukaryotic cells. Recently, a powerful aggregation activity for lipid vesicles and for the gram-n...

journal_title：Biomacromolecules

authors： Torrent M,Odorizzi F,Nogués MV,Boix E

更新日期：2010-08-09 00:00:00

abstract：:Cell cultivation on the surface of a novel poly(N-isopropylacrylamide) (PNIPA) hydrogel (N-NC gel), consisting of a specific type of organic (PNIPA)/inorganic (clay) network, was studied using three cell types; HepG2 human hepatoma cells, human dermal fibroblasts, and human umbilical vein endothelial cells. For the fi...

journal_title：Biomacromolecules

authors： Haraguchi K,Takehisa T,Ebato M

更新日期：2006-11-01 00:00:00

abstract：:Polyrotaxanes, a family of rod-shaped nanomaterials comprised of noncovalent polymer/macrocycle assemblies, are being used in a growing number of materials and biomedical applications. Their physiochemical properties can vary widely as a function of composition, potentially leading to different in vivo performance out...

journal_title：Biomacromolecules

authors： Collins CJ,Mondjinou Y,Loren B,Torregrosa-Allen S,Simmons CJ,Elzey BD,Ayat N,Lu ZR,Thompson D

更新日期：2016-09-12 00:00:00

abstract：:To broaden the application scope of lactic acid polymers, a new miniemulsion of poly(alkyl methacrylate-graft-lactic acid)s has been developed. The graft copolymer synthesis was based on a poly(lactic acid) macromonomer having a methacryloyl polymerizable group. The macromonomer and a comonomer of n-butyl methacrylate...

journal_title：Biomacromolecules

authors： Ishimoto K,Arimoto M,Ohara H,Kobayashi S,Ishii M,Morita K,Yamashita H,Yabuuchi N

更新日期：2009-10-12 00:00:00

abstract：:Microbial biofilms are ubiquitous in nature, and they pose a serious threat to public health. Staphylococcus epidermidis is the most common clinical isolate from healthcare- and medical device-related biofilm infections. No antibiotic currently on the market can eradicate pathogenic biofilms, which contain complex def...

journal_title：Biomacromolecules

authors： Lam AK,Wouters CL,Moen EL,Pusavat J,Rice CV

更新日期：2019-10-14 00:00:00