Abstract:
:Previous studies have demonstrated that Staphylococcus epidermidis isolates colonizing the skin of healthy humans do not typically encode icaADBC, the genes responsible for the production of polysaccharide intercellular adhesin or biofilms. It was therefore hypothesized that the presence of icaADBC was deleterious to the successful colonization of human skin by S. epidermidis. Using a human skin competition model, it was determined that the strong biofilm-producing S. epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica::dhfr), suggesting a fitness cost for carriage of icaADBC.
journal_name
Appl Environ Microbioljournal_title
Applied and environmental microbiologyauthors
Rogers KL,Rupp ME,Fey PDdoi
10.1128/AEM.01017-08subject
Has Abstractpub_date
2008-10-01 00:00:00pages
6155-7issue
19eissn
0099-2240issn
1098-5336pii
AEM.01017-08journal_volume
74pub_type
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