The presence of icaADBC is detrimental to the colonization of human skin by Staphylococcus epidermidis.

Abstract:

:Previous studies have demonstrated that Staphylococcus epidermidis isolates colonizing the skin of healthy humans do not typically encode icaADBC, the genes responsible for the production of polysaccharide intercellular adhesin or biofilms. It was therefore hypothesized that the presence of icaADBC was deleterious to the successful colonization of human skin by S. epidermidis. Using a human skin competition model, it was determined that the strong biofilm-producing S. epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica::dhfr), suggesting a fitness cost for carriage of icaADBC.

journal_name

Appl Environ Microbiol

authors

Rogers KL,Rupp ME,Fey PD

doi

10.1128/AEM.01017-08

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

6155-7

issue

19

eissn

0099-2240

issn

1098-5336

pii

AEM.01017-08

journal_volume

74

pub_type

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