Cytopathology of pathogenic and nonpathogenic Naegleria species for cultured rat neuroblastoma cells.

Abstract:

:The cytopathology for rat neuroblastoma cells (B-103) and the pathogenicity for B6C3F1 mice of four species of Naegleria have been compared. Both live amoebae and cell-free extracts of N. australiensis, N. fowleri, N. gruberi, and N. lovaniensis added to 51Cr-labeled B-103 cells caused release of radiolabel. All four species of Naegleria exhibited surface extensions termed food cups. Only N. fowleri and N. australiensis were pathogenic for mice. Electron microscopic observations of cultures of either N. australiensis or N. lovaniensis with B-103 cells established that the cytopathology involved lysis of the B-103 target cells.

journal_name

Appl Environ Microbiol

authors

Marciano-Cabral FM,Fulford DE

doi

10.1128/AEM.51.5.1133-1137.1986

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

1133-7

issue

5

eissn

0099-2240

issn

1098-5336

journal_volume

51

pub_type

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