A probable role for vaccines containing thimerosal in thimerosal hypersensitivity.

Abstract:

:We patch tested 141 patients with 0.05% aq. thimerosal and 222 patients with 0.05% aq. mercuric chloride, including 63 children. The frequency of positive patch test reactions to thimerosal was 16.3%. There was a marked preponderance in the young age groups after vaccination, while none of 36 infants (aged 3-48 months) reacted to thimerosal. Positive reactions to mercuric chloride were found in 23 (10.4%) of 222 patients. We also sensitized guinea pigs with diphtheria-pertussis-tetanus (DPT) vaccine containing 0.01% thimerosal and succeeded in inducing hypersensitivity to thimerosal. From patch testing in humans and animal experiments, it is suggested that 0.01% thimerosal in vaccines can sensitize children, and that hypersensitivity to thimerosal is due to the thiosalicylic part of the molecule and correlates with photosensitivity to piroxicam.

journal_name

Contact Dermatitis

journal_title

Contact dermatitis

authors

Osawa J,Kitamura K,Ikezawa Z,Nakajima H

doi

10.1111/j.1600-0536.1991.tb01694.x

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

178-82

issue

3

eissn

0105-1873

issn

1600-0536

journal_volume

24

pub_type

杂志文章
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