Abstract：
:Disperse Blue 106 is an acknowledged skin-sensitization hazard. However, information about the relative sensitization potency of this chemical is lacking, and to provide this information was the purpose of the investigations described here. The approach taken was to measure dose-response relationships for C.I. Disperse Blue in the local lymph node assay, a method for the assessment of skin-sensitization potential in which activity is measured as a function of lymphocyte proliferative responses induced in draining lymph nodes. From these data, it was possible to derive EC3 values (such being the estimated concentration of chemical required to elicit a 3-fold increase in proliferation) that have been shown previously to reflect the relative sensitizing potency of contact allergens. These analyses revealed that Disperse Blue 106 had a relatively low EC3 value (0.01%), comparable to that measured concurrently for 2,4-dinitrochlorobenzene, a potent contact allergen. Collectively, these data reveal that Disperse Blue 106 represents a significant skin-sensitization hazard, and, in combination with information on dye migration and percutaneous penetration from various types of fabric and use conditions provide a basis for the development of effective and accurate risk assessments.
journal_name
Contact Dermatitisjournal_title
Contact dermatitisauthors
Betts CJ,Dearman RJ,Kimber I,Maibach HIdoi
10.1111/j.0105-1873.2005.00578.xkeywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
268-72issue
5eissn
0105-1873issn
1600-0536pii
COD578journal_volume
52pub_type
杂志文章abstract：:A case of triphenyl phosphate allergy from spectacle frames is reported. Patch tests with analytical grade triphenyl phosphate, tri-m-cresyl phosphate, and tri-p-cresyl phosphate in the concentrations 5%, 0.5% and 0.05% pet. showed positive reactions to 0.05% triphenyl phosphate and 0.5% tri-m-cresyl phosphate, but no...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1986.tb01367.x
更新日期：1986-11-01 00:00:00
abstract：:Metal to metal prostheses give satisfactory results in 90% of patients. About half of the failure rate may be due to allergic reaction to the metals involved, particularly cobalt. A total of 35 patients in this unsatisfactory group have been patch-tested; 16 were positive to metals, 13 to cobalt, 4 to nickel, and 2 to...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1976.tb02986.x
更新日期：1976-04-01 00:00:00
abstract：:A way of adapting a treatment room for patch test purposes is described. ...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1975.tb05362.x
更新日期：1975-06-01 00:00:00
abstract：BACKGROUND:Chromium-tanned leather footwear, which releases >3 ppm hexavalent Cr(VI), may pose a risk of sensitizing and eliciting allergic dermatitis. OBJECTIVES:To determine the content and potential release of chromium in leather footwear and to discuss the prevention of chromium contact allergy and dermatitis. ME...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2011.02053.x
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer, and has been reported to cause allergic contact dermatitis (ACD). OBJECTIVES:To report our experience with contact allergy and ACD caused by lavender, and to rai...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/cod.13247
更新日期：2019-07-01 00:00:00
abstract：:We have studied a group of 104 patients with pompholyx, to investigate the relationship between allergological factors and its etiopathogenesis. The following examinations were performed: blood sampling (routine tests and IgE levels), allergological tests (patch, prick, intradermal, and oral provovation tests with nic...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1992.tb00862.x
更新日期：1992-01-01 00:00:00
abstract：:In cases of conjunctivitis associated with the use of soft lenses, delayed hypersensitivity to disinfecting components of the used soft lens liquids has to be considered. In 7/15 patients, positive patch test reactions to merthiolate, chlorhexidine or the soaking solutions were observed. The significance of these find...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1980.tb04956.x
更新日期：1980-08-01 00:00:00
abstract：BACKGROUND:Contact allergy prevalence rates change over time as a result of variations in allergen exposure. Data from patch test clinics are often used as markers for allergy trends. OBJECTIVES:The aim of the present retrospective study was to describe trends in rates of sensitization to allergens in the Swedish base...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/cod.12346
更新日期：2015-05-01 00:00:00
abstract：:The phenomenon of 'sensitive skin' is a relatively recent complaint in which certain individuals report more intense and frequent adverse sensory effects than the normal population upon use of cosmetic (personal-care) products. Originally defined as a minority complaint, sensitive skin is now claimed by a majority of ...
journal_title：Contact dermatitis
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0536.2009.01697.x
更新日期：2010-03-01 00:00:00
abstract：:Metallic aluminium and methylene blue applied to human skin interact and give a strong resistant coloration, obtained neither with methylene blue itself nor with other dyes. The reaction proves that aluminium is not an inert material and that the aluminium in Finn chambers can be expected to interact with other patch ...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1985.tb01031.x
更新日期：1985-01-01 00:00:00
abstract：:Sixteen patients with verified light sensitivity to both UVB and UVA wavebands showed allergic reactions to various lichen plants (Parmelia spp., Hypogymnia spp., Pseuodovernia spp., Cladonia spp., Platismatia spp., Physcia spp., Umbilicaria spp. and Cetraria spp.). Among the aromatic lichen compounds, atranorin was o...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1980.tb03911.x
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:Occupational skin diseases (OSDs) often have considerable medical and occupational consequences. Previous data on prognostic factors have been derived from studies with fairly small sample sizes. OBJECTIVES:To determine the medical and occupational outcome in 1048 patients diagnosed with OSD at the Finnish ...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2009.01611.x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Although citation analysis represents an increasingly common method for examining the performance of scientific journals, few longitudinal studies have been conducted in the specialist fields of dermatology. OBJECTIVES:The objective of this study was to provide the first comprehensive bibliometric analysis ...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2009.01609.x
更新日期：2009-10-01 00:00:00
abstract：:The present report describes experimental studies on the proteolytic activity of the secretion on the surface of okra pods and the allergenicity of okra components, to clarify the etiology of skin lesions due to okra. Proteolytic activity was detected on the surface of immature okra pods and seemed to be sufficient to...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1992.tb00891.x
更新日期：1992-02-01 00:00:00
abstract：:Allergic contact dermatitis caused by medical devices for diabetes patients has been increasingly described in the literature in the last few years. This article reviews the cases of allergic contact dermatitis caused by insulin pumps and glucose sensors reported since the 1970s, the culprit allergen(s), the results o...
journal_title：Contact dermatitis
pub_type： 杂志文章,评审
doi：10.1111/cod.13120
更新日期：2018-12-01 00:00:00
abstract：:We showed earlier that most patients with contact dermatitis due to corticosteroids show cross-reactions when patch tested with hydrocortisone-17-butyrate (H-17-B). To test whether H-17-B could be used for detecting topical corticosteroid allergy, we screened patients undergoing routine patch testing with H-17-B. Pati...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1989.tb04729.x
更新日期：1989-09-01 00:00:00
abstract：:The laser Doppler perfusion scanning technique is an objective, non-invasive assessment method that may be used to assess patch tests. The purpose of this paper is to focus on its clinical use in individuals with light skin, tested with non-pigmented test materials. A laser Doppler perfusion imager PIM 1.0 (LDPI) is u...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1999.tb06059.x
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Corticosteroids (CS), anti-inflammatory drugs also widely used to treat various allergic diseases, may themselves give rise to immediate and delayed allergic hypersensitivity reactions. OBJECTIVES:To realise an appropriate diagnostic work-up in order to determine the CS-allergic patient's sensitization/tole...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2011.01967.x
更新日期：2012-01-01 00:00:00
abstract：:Patch testing was carried out in 851 atopic patients; 181 atopic dermatitis (AD) patients were additionally tested with 50% dilutions of the test substances. The occurrence of allergic and irritant reactions was frequent, being 57% and 33% for AD patients aged 28-41 years and 19-27 years, respectively. Among age-match...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1992.tb00235.x
更新日期：1992-04-01 00:00:00
abstract：:The frequencies of cosmetics intolerance and contact allergy to colophony were investigated among 116 singers and dancers and 16 make-up artists. Participants were interviewed, examined and patch tested with a standard series and materials from the opera house. Common skin lesions were found in 1/3 of participants and...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1995.tb00780.x
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:Reviews on irritant and allergic airborne contact dermatitis have been previously reported in the literature. MATERIALS AND METHODS:Here, we present an update based on recently published airborne-induced skin reactions. For this survey, we screened the journals Contact Dermatitis, Dermatitis, and included r...
journal_title：Contact dermatitis
pub_type： 杂志文章,评审
doi：10.1111/cod.12022
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to determine the types of side-effects occurring and for how long they lasted in a group of patients with side-effects assessed to be caused by resin-based materials. METHODS:A total of 618 reports were received by the Swedish National Register of Side-Effects to Dental Mater...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2009.01590.x
更新日期：2009-12-01 00:00:00
abstract：:Recognizing the growing need for international standardization of photopatch testing techniques, a standard procedure has been used by Scandinavian dermatological clinics since January 1980. The set-up includes a standardized patient examination scheme, including phototest evaluation of the patient's UVA- and UVB-sens...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1982.tb04174.x
更新日期：1982-05-01 00:00:00
abstract：:To investigate the mechanisms of non-immunologic contact urticaria (NICU), the effect of 120 mg of terfenadine (H1-antagonist) on contact reactions to methyl nicotinate, diethyl fumarate, benzoic acid, cinnamic acid, cinnamic aldehyde and dimethyl sulfoxide was studied in 20 subjects. Erythema and edema were observed ...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.1987.tb01429.x
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Patch tests help to confirm the aetiology of the cutaneous adverse drug reactions involving delayed hypersensitivity mechanisms, but the results vary with the pattern of skin reaction and the culprit drug. OBJECTIVES:To analyse the results of patch tests in patients with cutaneous adverse drug reactions imp...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/j.1600-0536.2011.01942.x
更新日期：2011-10-01 00:00:00
abstract：:Numerous studies have investigated the prevalence and risk factors of hand eczema in the general population. These studies are of high value as they tend to be less biased than studies using clinical populations and as they are important for healthcare decision makers when they allocate resources. This study aimed to ...
journal_title：Contact dermatitis
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0536.2009.01669.x
更新日期：2010-02-01 00:00:00
abstract：:3-Iodo-2-propynyl-butylcarbamate (IPBC) is a fungicide used in both industrial products and cosmetics. We report the first case of allergic contact dermatitis from airborne exposure to this preservative. A 34-year-old female production worker at a paint factory developed dermatitis on air-exposed skin areas. Patch tes...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1034/j.1600-0536.2003.00079.x
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Thiurams and dithiocarbamates are structurally related sensitizing rubber accelerators. OBJECTIVES:To study patterns of simultaneous patch test reactions to thiurams and dithiocarbamates at the Finnish Institute of Occupational Health in 1991-2015. METHODS:We searched the patch test files for patients with...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/cod.12687
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Chromium-tanned leather articles currently constitute the most important cause of contact allergy to chromium in Denmark. A regulation on the content of hexavalent chromium in leather was adopted in November 2013 by the EU member states. OBJECTIVES:To characterize patients with chromium allergy and their di...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1111/cod.12291
更新日期：2014-12-01 00:00:00
abstract：:There is a widespread, but largely unsubstantiated, view that certain skin types may be more susceptible to the effect of skin irritants than others. One expression of this would be that certain ethnic groups may also be more likely to experience skin irritation. As a consequence, when evaluating the skin compatibilit...
journal_title：Contact dermatitis
pub_type： 杂志文章
doi：10.1034/j.1600-0536.2001.450605.x
更新日期：2001-12-01 00:00:00
