Abstract:
:We used multi-locus sequence typing (MLST) to investigate 35 yeast isolates representing the two genome-sequenced strains plus the type strain of Candida albicans, four isolates originally identified as Candida stellatoidea type I and 28 representing type strains of other species now regarded as synonymous with C. albicans. DNA from all 32 C. albicans synonyms readily formed PCR products with the C. albicans MLST primer sets. Their sequences placed all of them within the existing C. albicans clade structure, represented by 1516 isolates. One isolate, originally received as Mycotorula sinensis, was resistant to flucytosine, but no other unusual susceptibilities were found to polyene, azole or echinocandin antifungal agents. The four isolates of C. stellatoidea type I coclustered with two other sucrose-negative isolates, originally identified as examples of Candida africana, in a group of strains highly distinct from the majority of C. albicans. Our results not only confirm the synonymity of all the isolates with C. albicans but also confirm an obvious genotypic difference in the case of C. stellatoidea type I.
journal_name
FEMS Yeast Resjournal_title
FEMS yeast researchauthors
Jacobsen MD,Boekhout T,Odds FCdoi
10.1111/j.1567-1364.2008.00392.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
764-70issue
5eissn
1567-1356issn
1567-1364pii
FYR392journal_volume
8pub_type
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