Renin inhibitors: optimal strategy for renal protection.

abstract：:We are used to thinking of angiotensin (Ang) II as a regulatory hormone that stimulates constriction of vascular smooth muscle cells, aldosterone release from the adrenal gland, and sodium reabsorption in the renal tubule. We have also become accustomed to understanding that Ang II may be formed and may act locally as...

journal_title：Current hypertension reports

authors： Luft FC

更新日期：2001-02-01 00:00:00

abstract：:Essential hypertension is characterized by endothelial dysfunction due to reduced availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals. Some antihypertensive drugs may improve or restore endothelial function independently of their blood pressure lowering effect. The newer generat...

journal_title：Current hypertension reports

authors： Virdis A,Ghiadoni L,Taddei S

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To estimate the impact of the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guidelines for high blood pressure (BP) on the next hypertension guidelines in Asia. RECENT FINDINGS:The 2017 ACC/AHA guidelines for high BP in adults changed the diagnostic threshold and the manage...

journal_title：Current hypertension reports

authors： Nakagawa N,Hasebe N

更新日期：2019-01-10 00:00:00

abstract：:High-quality medical care requires implementing evidence-based best practices, with continued monitoring to improve performance. Implementation science is beginning to identify approaches to developing, implementing, and evaluating quality improvement strategies across health care systems that lead to good outcomes fo...

journal_title：Current hypertension reports

authors： Goldstein MK

更新日期：2008-06-01 00:00:00

abstract：:To further understand chronic heart disease, such as heart failure and cardiomyopathy, we must fully define signaling pathways within the myocardium. Recent studies suggest that some forms of heart disease are associated with a chronic low-grade inflammation that promotes adverse ventricular remodeling and correlates ...

journal_title：Current hypertension reports

authors： Ahn J,Kim J

更新日期：2012-12-01 00:00:00

abstract：:Albuminuria is an early marker for diabetic nephropathy in patients with diabetes, and has a clear place in patient care. It also predicts cardiovascular events and mortality in diabetic patients and in the general population, and is slowly becoming accepted in population screening for cardiovascular disease and chron...

journal_title：Current hypertension reports

authors： Bakker SJ,Gansevoort RT,de Zeeuw D

更新日期：2009-04-01 00:00:00

abstract：:Hypertension is a preventable condition, and the outcomes of clinical trials have established that its treatment reduces cardiovascular morbidity and mortality. Although awareness about the disease has improved in the past two decades, the reality is that many people remain untreated or not adequately controlled. The ...

journal_title：Current hypertension reports

authors： Nunes MI

更新日期：2001-12-01 00:00:00

abstract：:Over the last few decades, there has been increasing emphasis on cardiovascular disease in women and study of female-specific cardiovascular risk factors. Hypertension in pregnancy, and specifically preeclampsia, has been identified as one such risk factor. In this review, we explore the epidemiological evidence for p...

journal_title：Current hypertension reports

authors： Scantlebury DC,Hayes SN

更新日期：2014-09-01 00:00:00

abstract：:Aldosterone antagonists have been highly successful in treating congestive heart failure and resistant hypertension. Until recently, therapies targeting the mineralocorticoid receptor in chronic kidney disease (CKD) have received little attention, largely because of the risk of hyperkalemia and the incorrect assumptio...

journal_title：Current hypertension reports

authors： Volk MJ,Bomback AS,Klemmer PJ

更新日期：2011-08-01 00:00:00

abstract：:Hypertension (especially systolic hypertension) is very common in older persons. Systolic hypertension occurs because large conduit arteries become stiffer with age. Strong evidence from randomized trials suggests that treating systolic blood pressures initially higher than 160 mm Hg is extremely beneficial, and a rec...

journal_title：Current hypertension reports

authors： Hyman DJ,Taffet GE

更新日期：2009-10-01 00:00:00

abstract：:Circulating angiotensin II (Ang II) combined with high salt intake increases sympathetic nerve activity (SNA) in some forms of hypertension. Ang II-induced increases in SNA are modest, delayed, and specific to certain vascular beds. The brain targets for circulating Ang II are neurons in the area postrema (AP), subfor...

journal_title：Current hypertension reports

authors： Osborn JW,Fink GD,Sved AF,Toney GM,Raizada MK

更新日期：2007-06-01 00:00:00

abstract：:Resistant hypertension is a common and growing clinical problem characterized by failure to achieve target blood pressure levels despite adequate use of at least three antihypertensive agents. Although numerous safe and effective pharmacologic therapies are available to treat elevated blood pressure, novel therapeutic...

journal_title：Current hypertension reports

authors： Schlaich MP,Krum H,Esler MD

更新日期：2010-08-01 00:00:00

abstract：:Hypertension and high serum cholesterol levels are two of the most relevant risk factors for cardiovascular diseases. A combined increase in both risk factors has been reported in a significant proportion of patients with coronary artery disease. Statins are the most widely used drugs to treat hypercholesterolemia, an...

journal_title：Current hypertension reports

authors： Borghi C,Veronesi M,Prandin MG,Dormi A,Ambrosioni E

更新日期：2001-08-01 00:00:00

abstract：:The discovery of angiotensin-converting enzyme (ACE) 2 adds a new level of complexity to the understanding of the renin-angiotensin system. The high catalytic efficiency of ACE2 for the generation of angiotensin (ANG)-1-7 from ANG II suggests an important role of ACE2 in preventing ANG II accumulation, while at the sa...

journal_title：Current hypertension reports

authors： Wysocki J,González-Pacheco FR,Batlle D

更新日期：2008-02-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) is a major proteolytic system that regulates the degradation of intracellular proteins in the heart. The UPS regulates the turnover of misfolded and damaged proteins, in addition to numerous cellular processes, by affecting the stability of short-lived proteins such as transcripti...

journal_title：Current hypertension reports

authors： Rodríguez JE,Schisler JC,Patterson C,Willis MS

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer's disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in ex...

journal_title：Current hypertension reports

authors： Yasar S,Schuchman M,Peters J,Anstey KJ,Carlson MC,Peters R

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS:Recent trials testing the ef...

journal_title：Current hypertension reports

authors： Fudim M,Sobotka AA,Yin YH,Wang JW,Levin H,Esler M,Wang J,Sobotka PA

更新日期：2018-05-01 00:00:00

abstract：:Elevation of blood pressure (BP) and the risk for progression to hypertension (HTN) is of increasing concern in children and adolescents. Indeed, it is increasingly recognized that target organ injury may begin with even low levels of BP elevation. Sodium intake has long been recognized as a modifiable risk factor for...

journal_title：Current hypertension reports

authors： Hanevold CD

更新日期：2013-10-01 00:00:00

abstract：:This paper critically addresses the issue of the "J-curve" paradox--the finding described in studies performed about 30 years ago indicating that treatment-induced systolic blood pressure values below 120 or 125 mm Hg and diastolic blood pressure values below 75 mm Hg are characterized by an increase, rather than a re...

journal_title：Current hypertension reports

authors： Grassi G,Quarti-Trevano F,Dell'Oro R,Mancia G

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this meta-analysis is to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on blood pressure of hypertensive individuals. RECENT FINDINGS:Continuous aerobic training programs are successful in health promotion and are effec...

journal_title：Current hypertension reports

authors： Leal JM,Galliano LM,Del Vecchio FB

更新日期：2020-03-03 00:00:00

abstract：PURPOSE OF REVIEW:Automated office blood pressure (AOBP) measurements may provide more accurate estimation of blood pressure (BP) than manual office blood pressure (MOBP) measurements. This systematic review investigated the diagnostic performance of AOBP and MOBP using ambulatory blood pressure measurement (ABPM) as r...

journal_title：Current hypertension reports

authors： Bo Y,Kwok KO,Chu KK,Leung EY,Yu CP,Wong SY,Lee EK

更新日期：2021-01-15 00:00:00

abstract：PURPOSE OF REVIEW:To review medical literature for evidence of association between hypertension and mitral regurgitation (MR) and summarize potential favorable effects of antihypertensive drugs on MR natural history and treatment. RECENT FINDINGS:Hypertension and MR are common diseases affecting a large proportion of ...

journal_title：Current hypertension reports

authors： Katsi V,Georgiopoulos G,Magkas N,Oikonomou D,Virdis A,Nihoyannopoulos P,Toutouzas K,Tousoulis D

更新日期：2019-02-28 00:00:00

abstract：:The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)-Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective ro...

journal_title：Current hypertension reports

authors： Bennion DM,Haltigan E,Regenhardt RW,Steckelings UM,Sumners C

更新日期：2015-02-01 00:00:00

abstract：:Chronic kidney disease is a major public health problem worldwide: it is estimated that in the general population, 1 person in 10 has some degree of renal damage. Adequate blood pressure control represents the mainstay of treatment, to delay deterioration of renal function and prevent cardiovascular complications. Cur...

journal_title：Current hypertension reports

authors： Leoncini G,Viazzi F,Pontremoli R

更新日期：2010-10-01 00:00:00

abstract：:Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and mid...

journal_title：Current hypertension reports

authors： Yano Y,Lloyd-Jones DM

更新日期：2016-11-01 00:00:00

abstract：:The epidemiology of pulmonary arterial hypertension (PAH) has changed over the last decade. Remarkable advances in understanding the pathobiology and clinical care required in PAH have resulted in improved quality of life and survival. Despite such important progress, the long-term rate of survival is still unacceptab...

journal_title：Current hypertension reports

authors： Jiang X,Jing ZC

更新日期：2013-12-01 00:00:00

abstract：:Masked hypertension refers to the phenomenon of having a non-elevated clinic blood pressure (BP) despite having an elevated out-of-clinic BP. Masked hypertension is a common phenotype with a cardiovascular risk profile similar to that of sustained hypertension, defined as elevated clinic and out-of-clinic BP. Current ...

journal_title：Current hypertension reports

authors： Anstey DE,Pugliese D,Abdalla M,Bello NA,Givens R,Shimbo D

更新日期：2017-10-25 00:00:00

abstract：:The treatment of hypertension is proven to reduce cardiovascular and renal risk. Combination drug therapy is becoming recognized as a necessity in most patients with hypertension and kidney disease. Allegations about the safe use of calcium antagonists in patients with kidney disease have led to questions and confusio...

journal_title：Current hypertension reports

authors： Tobe S,Epstein M

更新日期：2002-06-01 00:00:00

abstract：:Diabetes and hypertension are common coexistent conditions, the combination of which results in an increased risk for cardiovascular and renal disease. Clinical trials have convincingly demonstrated the benefit of tight blood pressure control among patients with diabetes in reducing these risks. Furthermore, the choic...

journal_title：Current hypertension reports

authors： Borzecki AM,Berlowitz DR

更新日期：2005-12-01 00:00:00

abstract：:Na+,K+-ATPase distributes ions between the intracellular and extracellular space and is responsible for total-body sodium homeostasis. The activity of this ion pump is regulated by catecholamines and peptide hormones; by the ligand of Na+,K+-ATPase, ouabain; and by direct interaction with cytoskeleton proteins. This r...

journal_title：Current hypertension reports

authors： Aperia A

更新日期：2001-04-01 00:00:00