当前位置： SCI文献检索 > TOXICOLOGY LETTERS期刊下所有文献 > Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders.

Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders.

Abstract：

:Human saliva offers a unique noninvasive approach for populational study. Purposes of this study were to investigate the feasibility of using saliva manganese (Mn) concentration as a biomarker of Mn exposure among career welders and to study the variations of Mn, copper (Cu), zinc (Zn), cadmium (Cd), and lead (Pb) in saliva as affected by the welding profession. Forty-nine male welders, of whom 28 were in the low exposed group and 21 in the high exposed group, were recruited. Control subjects were 33 military soldiers without metal exposure. Ambient Mn levels in breathing zones were 0.01, 0.24 and 2.21mg/m(3) for control, low, and high exposed groups, respectively. Saliva samples were collected to quantify metals by inductive coupled plasma mass spectrometer (ICP-MS). Saliva concentrations of Mn and Cu were significantly higher in welders than in controls (p<0.01); the variation in saliva levels appeared likely to be associated with airborne Mn levels among study populations. Saliva levels of Zn were significantly lower in welders than in controls (p<0.05), while Cd and Pb levels in saliva were unchanged. Significant associations were observed between saliva and serum for Mn (r=0.575, p<0.05) and Cu (r=0.50, p<0.05). Moreover, saliva Mn concentrations were higher among welders with 5-10years of employment than those with less than 5years of employment. Linear regression analysis revealed a significant correlation between saliva Mn and Cu and between saliva Mn and Zn. Taken together, these data suggest that Mn concentrations in saliva appear reflective of welders' exposure to airborne Mn and their years of welding experience, respectively. Elevated Mn levels among welders may alter the homeostasis of Cu and Zn.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Wang D,Du X,Zheng W

doi

10.1016/j.toxlet.2007.10.003

subject

Has Abstract

pub_date

2008-01-04 00:00:00

pages

40-7

issue

1

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(07)00975-7

journal_volume

176

pub_type

杂志文章,多中心研究

相关文献

TOXICOLOGY LETTERS文献大全
  • Dose dependent molecular effects of acrylamide and glycidamide in human cancer cell lines and human primary hepatocytes.

    abstract：:Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms are still unknown and in particular the molecular effects of ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2012.12.017

    authors： Ehlers A,Lenze D,Broll H,Zagon J,Hummel M,Lampen A

    更新日期：2013-02-27 00:00:00

  • Repeated exposure of C57Bl mice to inhaled benzene at 10 ppm markedly depressed erythropoietic colony formation.

    abstract：:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(84)90169-3

    authors： Baarson KA,Snyder CA,Albert RE

    更新日期：1984-03-01 00:00:00

  • Interaction of acrylonitrile with hepatic microsomes of rats and men.

    abstract：:Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(81)90057-6

    authors： Appel KE,Peter H,Bolt M,Bolt HM

    更新日期：1981-02-01 00:00:00

  • Comparison of in vivo and in vitro methods for assessing the effects of carbon tetrachloride on the hepatic drug-metabolizing enzyme system.

    abstract：:The effect of a single i.p. injection of 0, 20, 200, and 1000 microliter/kg carbon tetrachloride on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane (gamma-hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in this...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(88)90116-6

    authors： Chadwick RW,Copeland MF,Carlson GP,Trela BA,Most BM

    更新日期：1988-09-01 00:00:00

  • Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE).

    abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(93)90126-i

    authors： Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

    更新日期：1993-05-01 00:00:00

  • Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.

    abstract：:Benzodiazepines have wide-spread used in pharmacotherapy for their anxiolytic, myorelaxant, hypnotic, amnesic and anticonvulsive properties. Despite benzodiazepines are used in clinics over 50 years, they have not been surprisingly tested for capability to induce major drug-metabolizing cytochromes P450. In the curren...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2010.01.004

    authors： Vrzal R,Kubesova K,Pavek P,Dvorak Z

    更新日期：2010-03-15 00:00:00

  • Effects of X-irradiation on nerve growth factor in the developing mouse brain.

    abstract：:The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(96)03827-1

    authors： Dimberg Y,Vazquez M,Söderström S,Ebendal T

    更新日期：1997-01-15 00:00:00

  • Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication.

    abstract：:Lindane administration to rats (60 mg/kg b.w.) led to an enhancement in the oxidative stress status of the liver at 4 h after treatment, characterized by increases in hepatic thiobarbituric acid reactants (TBARS) formation and chemiluminescence, reduced glutathione (GSH) depletion, and diminution in the biliary conten...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(00)00172-7

    authors： Videla LA,Arisi AC,Fuzaro AP,Koch OR,Junqueira VB

    更新日期：2000-04-10 00:00:00

  • Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.

    abstract：:Previous studies indicated that the enantiomers of thalidomide and its analogue EM12 exhibit differing teratogenic potencies. Unfortunately, these substances proved to be unstable and racemised considerably, so that the intrinsic teratogenic potencies of the pure enantiomers were difficult to elucidate. We have theref...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(89)90099-4

    authors： Hauck RS,Nau H

    更新日期：1989-10-01 00:00:00

  • Formaldehyde exposure impairs the function and differentiation of NK cells.

    abstract：:We investigated the cytotoxic effects of formaldehyde (FA) on lymphocytes. FA-exposed mice showed a profound reduction not only in the number of natural killer (NK) cells but also in the expression of NK cell-specific receptors, but these mice did not exhibit decreases in the numbers of T or B lymphocytes. FA exposure...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2013.09.008

    authors： Kim EM,Lee HY,Lee EH,Lee KM,Park M,Ji KY,Jang JH,Jeong YH,Lee KH,Yoon IJ,Kim SM,Jeong MJ,Kim KD,Kang HS

    更新日期：2013-11-25 00:00:00

  • How accurate are the European Union's classifications of chemical substances.

    abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(03)00204-2

    authors： Rudén C,Hansson SO

    更新日期：2003-09-30 00:00:00

  • Allergy, asthma and the environment: an introduction.

    abstract：:In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(98)00320-8

    authors： Kimber I

    更新日期：1998-12-28 00:00:00

  • Dichlorodiphenyltrichloroethane suppresses neurite outgrowth and induces apoptosis in PC12 pheochromocytoma cells.

    abstract：:It is well known that dichlorodiphenyltrichloroethane (DDT) is used as an insecticide and prevents many people in the tropical zone from devastating malaria. On the other hand, a number of reports have indicated that it may act as an endocrine disruptor and also has possible carcinogenic effects. However, the effects ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(02)00401-0

    authors： Shinomiya N,Shinomiya M

    更新日期：2003-02-03 00:00:00

  • Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells.

    abstract：:Central nervous system dysfunctions (most notably microencephaly and mental retardation) are among the most significant effects of in utero exposure to ethanol. Ethanol causes alterations of both neuronal and glial cells. In particular, ethanol has been shown to inhibit proliferation of astroglial cells stimulated by ...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.toxlet.2003.12.020

    authors： Costa LG,Vitalone A,Guizzetti M

    更新日期：2004-04-01 00:00:00

  • Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer.

    abstract：:Cigarette smoking is the strongest risk factor for lung cancer (LC), but genetically determined variations in pulmonary metabolism of tobacco-derived carcinogens may affect individual risk. Results from a case-control study on LC patients demonstrated the pronounced effect of tobacco smoke on pulmonary xenobiotic meta...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(92)90222-6

    authors： Bartsch H,Castegnaro M,Rojas M,Camus AM,Alexandrov K,Lang M

    更新日期：1992-12-01 00:00:00

  • MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs.

    abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2017.07.216

    authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

    更新日期：2017-08-05 00:00:00

  • Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.

    abstract：:The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2015.04.014

    authors： Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

    更新日期：2015-07-02 00:00:00

  • Reduction of phosphoinositides and diacylglycerol levels in repeatedly dibutyltin-dilaurate-treated rat brain.

    abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(91)90198-f

    authors： Subramoniam A,Husain R,Seth PK

    更新日期：1991-08-01 00:00:00

  • Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice.

    abstract：:We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/s0378-4274(00)00306-4

    authors： Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

    更新日期：2001-03-08 00:00:00

  • One-month persistence of inflammation and alteration of fibrotic marker and cytoskeletal proteins in rat kidney after Cd-doped silica nanoparticle instillation.

    abstract：:In vivo effects of model cadmium-containing silica nanoparticles (SiNPs-Cd, 1 mg/rat) were investigated by i.t. instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney. Specific endpoints and pathological outcomes were focused to assess inflammation and fibrosis in renal tissue, 7 an...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2014.11.021

    authors： Coccini T,Barni S,Mustarelli P,Locatelli C,Roda E

    更新日期：2015-01-22 00:00:00

  • Effects of inhalation exposure to carbon disulfide and its combination with hydrogen sulfide on embryonal and fetal development in rats.

    abstract：:Pregnant rats were exposed to 0, 100, 200, 400 or 800 ppm of carbon disulfide (CS2), 100 ppm of hydrogen sulfide (H2S) alone or in combination with 400 and 800 ppm CS2, 6 h/d during days 6-20 of gestation. Maternal reproduction and fetal parameters were evaluated on gestational day 21. Treatment with 100 or 200 ppm CS...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(89)90186-0

    authors： Saillenfait AM,Bonnet P,de Ceaurriz J

    更新日期：1989-07-01 00:00:00

  • Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates.

    abstract：:Aggregation of α-synuclein (α-syn) in the brain is a defining pathological feature of neurodegenerative disorders classified as synucleinopathies. They include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Occupational and environmental exposure to manganese (Mn) is asso...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2012.12.006

    authors： Verina T,Schneider JS,Guilarte TR

    更新日期：2013-03-13 00:00:00

  • The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds.

    abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0378-4274(94)90139-2

    authors： Okey AB,Riddick DS,Harper PA

    更新日期：1994-01-01 00:00:00

  • Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.

    abstract：:Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2004.02.009

    authors： Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

    更新日期：2004-05-02 00:00:00

  • Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.

    abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2012.08.027

    authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

    更新日期：2012-10-17 00:00:00

  • The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice.

    abstract：:Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2021.01.008

    authors： Zhu J,Li Y,Liang J,Li J,Huang K,Li J,Liu C

    更新日期：2021-01-08 00:00:00

  • Transfer of developmental neurotoxin β-N-methylamino-l-alanine (BMAA) via milk to nursed offspring: Studies by mass spectrometry and image analysis.

    abstract：:The cyanobacterial non-proteinogenic amino acid β-N-methylamino-l-alanine (BMAA) is proposed to be involved in the etiology of amyotrophic lateral sclerosis/parkinsonism dementia complex. When administered as single doses to neonatal rats, BMAA gives rise to cognitive and neurodegenerative impairments in the adult ani...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2016.06.015

    authors： Andersson M,Karlsson O,Banack SA,Brandt I

    更新日期：2016-09-06 00:00:00

  • Effect of argemone oil and argemone alkaloid, sanguinarine on Sertoli-germ cell coculture.

    abstract：:Several incidences of reduction in the fertility (sperm count) have been reported in India and worldwide as well. Adulteration of food and consumption of adulterated mustard oil with argemone oil (AO) are presumed to be the factors for reduction in sperm count. In the present study we have studied the exfoliation of g...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/j.toxlet.2009.01.006

    authors： Mishra V,Saxena DK,Das M

    更新日期：2009-04-25 00:00:00

  • Elimination pattern and biodistribution of [14C]chlorferron in rats.

    abstract：:Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-de...

    journal_title：Toxicology letters

    pub_type： 杂志文章

    doi：10.1016/0378-4274(81)90091-6

    authors： Malik JK,Lay JP,Klein W,Korte F

    更新日期：1981-03-01 00:00:00

  • Polymorphic CYP genes and disease predisposition--what have the studies shown so far?

    abstract：:The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...

    journal_title：Toxicology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-4274(98)00303-8

    authors： Watanabe M

    更新日期：1998-12-28 00:00:00