Glanders: off to the races with Burkholderia mallei.

Abstract:

:Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine available for either humans or animals. Despite the history and highly infective nature of B. mallei, as well as its potential use as a bio-weapon, B. mallei research to understand the pathogenesis and the host responses to infection remains limited. Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development.

journal_name

FEMS Microbiol Lett

authors

Whitlock GC,Estes DM,Torres AG

doi

10.1111/j.1574-6968.2007.00949.x

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

115-22

issue

2

eissn

0378-1097

issn

1574-6968

pii

FML949

journal_volume

277

pub_type

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