Abstract:
:Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine available for either humans or animals. Despite the history and highly infective nature of B. mallei, as well as its potential use as a bio-weapon, B. mallei research to understand the pathogenesis and the host responses to infection remains limited. Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Whitlock GC,Estes DM,Torres AGdoi
10.1111/j.1574-6968.2007.00949.xsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
115-22issue
2eissn
0378-1097issn
1574-6968pii
FML949journal_volume
277pub_type
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