Specific interaction of the protein-D2 porin of Pseudomonas aeruginosa with antibiotics.

Abstract:

:The protein-D2 porin of Pseudomonas aeruginosa is lacking in carbapenem or fluoroquinolone-resistant strains and hence was thought to facilitate the diffusion of these antibiotics. We examined the effect of several antibiotics on the single channel conductivity of protein-D2 in planar lipid bilayers and found that fluoroquinolones and carbapenems at concentrations of around 1 mM caused closure of the protein-D2 channel. Tetracycline, ampicillin, piperacillin, and latamoxef did not exert any detectable effect on the protein-D2 channel activity.

journal_name

FEMS Microbiol Lett

authors

Ishii J,Nakae T

doi

10.1016/0378-1097(95)00497-1

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

85-90

issue

1

eissn

0378-1097

issn

1574-6968

pii

0378109795004971

journal_volume

136

pub_type

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