Abstract：
:Behavioral and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (1) by i.p. injection of increasing doses of the drug; (2) by i.p. injection of morphine as a reward of a rat's visit to a certain compartment of the Y-maze; (3) by voluntary drinking a morphine solution. Animals with high sensitivity to the development of dependence induced by the first way initially demonstrated intensive ambulation and low rearing in the open field and low nociception in the tail flick test. In the second case the 'predisposed' animals had initially higher ambulation also in comparison with the 'resistant' ones, but did not demonstrate significant withdrawal symptoms. The rats imbibing morphine solution exhibited a withdrawal syndrome, low level of initial nociception and received more electrocutaneous stimuli in the Vogel test. Thus, marked differences of sensitivity to the development of morphine dependence are correlated with some initial behavioural and physiological indices and may be genetically and neurochemically determined.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Sudakov SK,Konstantinopolsky MA,Surkova LA,Tyurina IV,Borisova EVdoi
10.1016/0376-8716(91)90023-rsubject
Has Abstractpub_date
1991-12-01 00:00:00pages
69-75issue
1eissn
0376-8716issn
1879-0046pii
0376-8716(91)90023-Rjournal_volume
29pub_type
杂志文章abstract：BACKGROUND:Available evidence indicates women with substance use disorders may experience more rapid progression through usage milestones (telescoping). The few investigations of sex differences in treatment-seeking populations often focus on single substances and typically do not account for significant polysubstance ...
journal_title：Drug and alcohol dependence
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更新日期：2014-12-01 00:00:00
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journal_title：Drug and alcohol dependence
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pub_type： 杂志文章,评审
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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abstract：BACKGROUND:Heavy alcohol consumption may accelerate the progression of hepatitis C-related liver disease and/or limit efforts at antiviral treatment in opioid-dependent patients receiving heroin-assisted treatment (HAT). Our study aims to assess alcohol intake among HAT patients by self-reports compared to direct ethan...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(86)90013-x
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00337-x
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2005.06.006
更新日期：2006-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.03.005
更新日期：2007-10-08 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2005.07.003
更新日期：2006-02-28 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2010-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.01.007
更新日期：2018-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.07.018
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.10.003
更新日期：2013-04-01 00:00:00
abstract：:Data from research with laboratory animals indicate that cocaine self-administration can be reduced by lambda-aminobutyric acid (GABA) agonists. Yet, the effectiveness of GABA agonists to decrease human cocaine self-administration has not been investigated under controlled laboratory conditions. The purpose of this st...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2003.10.015
更新日期：2004-03-08 00:00:00
abstract：:This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factor...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2009.09.009
更新日期：2010-02-01 00:00:00
