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Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.

Abstract：

BACKGROUND:The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during midlife as a risk factor for developing depression during 28 years of follow-up. METHODS:We used data from a well characterised prospective cohort study (the Whitehall II study) of 7478 men and women (70% male) aged 35 to 55 years, and free from depression in 1985-1988, followed up regularly until 2013. Drinking pattern was defined in terms of usual and maximum amounts consumed within a single drinking session, total weekly volume of alcohol consumed and drinking frequency. Depression was assessed using the General Health Questionnaire Depression Subscale at multiple follow-up occasions (up to eight times in total). Associations between different drinking pattern components during midlife and depression were estimated using flexible parametric survival models. RESULTS:After adjustment for confounding factors only abstaining from alcohol during midlife was associated with an increased risk of developing depression during long-term observation. However, this association became non-significant after adjusting for baseline self-reported health. CONCLUSIONS:In this community dwelling population, drinking pattern during midlife was not associated with an increased risk of developing depression.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Bell S,Britton A

doi

10.1016/j.drugalcdep.2015.08.008

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

111-7

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(15)01599-9

journal_volume

155

pub_type

杂志文章

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