Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study.


BACKGROUND:The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during midlife as a risk factor for developing depression during 28 years of follow-up. METHODS:We used data from a well characterised prospective cohort study (the Whitehall II study) of 7478 men and women (70% male) aged 35 to 55 years, and free from depression in 1985-1988, followed up regularly until 2013. Drinking pattern was defined in terms of usual and maximum amounts consumed within a single drinking session, total weekly volume of alcohol consumed and drinking frequency. Depression was assessed using the General Health Questionnaire Depression Subscale at multiple follow-up occasions (up to eight times in total). Associations between different drinking pattern components during midlife and depression were estimated using flexible parametric survival models. RESULTS:After adjustment for confounding factors only abstaining from alcohol during midlife was associated with an increased risk of developing depression during long-term observation. However, this association became non-significant after adjusting for baseline self-reported health. CONCLUSIONS:In this community dwelling population, drinking pattern during midlife was not associated with an increased risk of developing depression.


Drug Alcohol Depend


Bell S,Britton A




Has Abstract


2015-10-01 00:00:00












  • Naltrexone shortened opioid detoxification with buprenorphine.

    abstract::This double-blind, randomized, placebo-controlled clinical trial evaluated the impact on withdrawal symptoms of (i) combining naltrexone with a 4-day buprenorphine taper for short opioid detoxification (NB Group), compared to (ii) using a 4-day buprenorphine taper alone, followed by naltrexone on day 8 (PB Group). Sub...

    journal_title:Drug and alcohol dependence

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Umbricht A,Montoya ID,Hoover DR,Demuth KL,Chiang CT,Preston KL

    更新日期:1999-10-01 00:00:00

  • DSM-5 cannabis use disorder: a phenotypic and genomic perspective.

    abstract:BACKGROUND:We explore the factor structure of DSM-5 cannabis use disorders, examine its prevalence across European- and African-American respondents as well as its genetic underpinnings, utilizing data from a genome-wide study of single nucleotide polymorphisms (SNPs). We also estimate the heritability of DSM-5 cannabi...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Agrawal A,Lynskey MT,Bucholz KK,Kapoor M,Almasy L,Dick DM,Edenberg HJ,Foroud T,Goate A,Hancock DB,Hartz S,Johnson EO,Hesselbrock V,Kramer JR,Kuperman S,Nurnberger JI Jr,Schuckit M,Bierut LJ

    更新日期:2014-01-01 00:00:00

  • Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.

    abstract:BACKGROUND:Gender differences in the prevalence and characteristics of misuse of methamphetamine (meth) and prescription stimulants were examined in a representative US sample of youths and young adults aged 16-25 (N=24,409). METHODS:Stimulant misusers were categorized into three mutually exclusive subgroups: meth use...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Wu LT,Pilowsky DJ,Schlenger WE,Galvin DM

    更新日期:2007-07-10 00:00:00

  • Early age at childhood parental incarceration and STI/HIV-related drug use and sex risk across the young adult lifecourse in the US: Heightened vulnerability of black and Hispanic youth.

    abstract:BACKGROUND:We measured associations between parental incarceration and STI/HIV-related drug use and sex risk, assessing differences by race, age at first parental incarceration, and potential mediators of the relationship. METHODS:We used Waves I (adolescence), III (young adulthood), and IV (adulthood) of the National...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Khan MR,Scheidell JD,Rosen DL,Geller A,Brotman LM

    更新日期:2018-02-01 00:00:00

  • PROP taster status and parental history of alcohol dependence.

    abstract::Pelchat and Danowski [Physiol. Behav. 1992;51:1261-1266] reported an association between the ability to taste 6-n-propylthiouracil (PROP) and a parental history of alcoholism. Kranzler et al. [Alcohol Clin. Exp. Res. 1996a;20:1496-1500] previously failed to replicate these findings in a sample of subjects with only a ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Kranzler HR,Skipsey K,Modesto-Lowe V

    更新日期:1998-10-01 00:00:00

  • 1-alpha-acetylmethadol (LAAM), methadone and morphine abstinence in dependent rats: EEG and behavioral correlates.

    abstract::Adult female Sprague-Dawley rats were prepared with chronic intravenous cannulas and cortical and muscle electrodes for recording electroencephalograms and electromyograms, respectively. They were made physically dependent on morphine by automatic intravenous injections and then trained to lever press in order to self...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Young GA,Moreton JE,Meltzer LT,Khazan N

    更新日期:1977-03-01 00:00:00

  • The iatrogenic epidemic of prescription drug abuse: county-level determinants of opioid availability and abuse.

    abstract:BACKGROUND:Opioid use and abuse in the United States continues to expand at an alarming rate. In this study, we examine the county-level determinants of the availability and abuse of prescription opioids to better understand the socio-ecological context, and in particular the role of the healthcare delivery system, on ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Wright ER,Kooreman HE,Greene MS,Chambers RA,Banerjee A,Wilson J

    更新日期:2014-05-01 00:00:00

  • Amphetamine withdrawal and sleep disturbance.

    abstract::Sleep duration and indices of disturbed sleep, such as night-time waking and day-time sleep, were investigated in amphetamine users following hospital admission and withdrawal from the drug. Compared to controls, the amphetamine group showed an initial period of oversleeping and, towards the end of the first week, the...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Gossop MR,Bradley BP,Brewis RK

    更新日期:1982-10-01 00:00:00

  • Receipt of alcohol-related care among patients with HCV and unhealthy alcohol use.

    abstract:BACKGROUND:Alcohol use-particularly unhealthy alcohol use-exacerbates risks associated with Hepatitis C virus (HCV). However, whether unhealthy alcohol use is appropriately addressed among HCV+ patients is understudied. We examined receipt of alcohol-related care among HCV+ patients and unhealthy alcohol use. METHODS:...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Owens MD,Ioannou GN,Tsui JL,Edelman EJ,Greene PA,Williams EC

    更新日期:2018-07-01 00:00:00

  • Major depression and treatment response in adolescents with ADHD and substance use disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) frequently co-occurs in adolescents with substance use disorders (SUDs) and attention deficit hyperactivity disorder (ADHD), but the impact of MDD on substance treatment and ADHD outcomes and implications for clinical practice are unclear. METHODS:Adolescents (n=303; ages 13-...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验


    authors: Warden D,Riggs PD,Min SJ,Mikulich-Gilbertson SK,Tamm L,Trello-Rishel K,Winhusen T

    更新日期:2012-01-01 00:00:00

  • Alcohol abuse in a rural community in India. Part I: Epidemiological study.

    abstract::By systematic sampling of households after two stage proportionate random sampling of villages, a total of 4670 persons above 15 years of age were selected from the rural areas of Ajmer district in Rajasthan, India, to estimate the prevalence rate of alcohol abuse and to study its socio-demographic correlates (Part I)...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Sundaram KR,Mohan D,Advani GB,Sharma HK,Bajaj JS

    更新日期:1984-09-01 00:00:00

  • The effect of abstinence in alcoholics of erythrocyte gangliosides.

    abstract::The pattern of gangliosides in membranes of erythrocytes was examined in healthy and in alcoholic subjects on the second and on the 28th day of detoxification therapy. The GM3 and GD3 fraction were decreased significantly in alcoholics on the 2nd day. After 4 weeks of abstinence all changes had returned to the level o...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Beyer I,Haselhorst U,Schenk H,Sue A,von Keyserlingk H

    更新日期:1990-08-01 00:00:00

  • Systemic barriers in substance use disorder treatment: A prospective qualitative study of professionals in the field.

    abstract:BACKGROUND:The US is in the midst of one of the largest public health crises in recent history with over 63,000 drug poisoning deaths in 2016 and a projected annual economic cost of over $420 billion. With the rise of deaths and economic burden related to substance use, it is paramount that systemic barriers within the...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Ashford RD,Brown AM,Curtis B

    更新日期:2018-08-01 00:00:00

  • Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and gender.

    abstract::Safety monitoring is a critical element of clinical trials evaluating treatment for substance dependence, but is complicated by participants' high levels of medical and psychiatric comorbidity. This paper describes AEs reported in a large (N = 286), 29-week outpatient study of behavioral interventions for heroin and c...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Schroeder JR,Schmittner JP,Epstein DH,Preston KL

    更新日期:2005-10-01 00:00:00

  • High uptake of naloxone-based overdose prevention training among previously incarcerated syringe-exchange program participants.

    abstract:BACKGROUND:Incarceration is common among people who inject drugs. Prior research has shown that incarceration is a marker of elevated risk for opioid overdose, suggesting that the criminal justice system may be an important, under-utilized venue for implementing overdose prevention strategies. To better understand the ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Barocas JA,Baker L,Hull SJ,Stokes S,Westergaard RP

    更新日期:2015-09-01 00:00:00

  • Drinking drivers and drug use on weekend nights in the United States.

    abstract:BACKGROUND:Studies of drinking drivers in alcohol-related crashes have shown that high breath-alcohol concentrations (BrACs) are associated with illegal drug use. Until the 2007 National Roadside Survey (NRS), the prevalence of drugs among drinking drivers on U.S. roads was unknown. Using NRS data, we explore how many ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Voas RB,Lacey JH,Jones K,Scherer M,Compton R

    更新日期:2013-06-01 00:00:00

  • Heavy alcohol consumption and physical health problems: a review of the epidemiological evidence.

    abstract::A review of morbidity and mortality studies bearing on the hazards to physical health of chronic heavy alchol use indicates that such use carries a risk of premature death greatly exceeding normal expectancy. While the life style typical of many heavy drinker contributes to this risk, the effects of alcohol per se acc...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审


    authors: Schmidt W,Popham RE

    更新日期:1975-09-01 00:00:00

  • Contextual renewal of cocaine seeking in rats and its attenuation by the conditioned effects of an alternative reinforcer.

    abstract::The present experiment investigated contextual renewal of cocaine seeking and potential methods of attenuating this renewal. Rats were first trained in one context to self-administer cocaine when a discriminative stimulus (tone) was presented. Then, the ABA Group was placed in a second context and responses in tone no...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Kearns DN,Weiss SJ

    更新日期:2007-10-08 00:00:00

  • Religion and alcohol in the U.S. National Alcohol Survey: how important is religion for abstention and drinking?

    abstract:OBJECTIVE:This paper examines the relative importance of three religion variables (religious preference, religiosity, and alcohol proscription) and eight demographic variables (gender, ethnicity, education, income, marital status, age, region, and employment status) as statistical predictors of drinking versus abstenti...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Michalak L,Trocki K,Bond J

    更新日期:2007-03-16 00:00:00

  • Locus of control in couples with different patterns of alcohol consumption.

    abstract::A sample of 175 individuals were interviewed and divided in three subgroups of couples: (1) the husband was in an Anonymous Alcoholics program, (2) the husband had been diagnosed as alcoholic and (3) the husband had a regular pattern of high alcohol consumption. In personal interviews by specialized personnel the foll...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Natera G,Herrejón ME,Casco M

    更新日期:1988-12-01 00:00:00

  • The practice of office-based buprenorphine treatment of opioid dependence: is it associated with new patients entering into treatment?

    abstract::Office-based buprenorphine holds the promise of bringing patients who have never received pharmacotherapy into treatment. In a cross-sectional and longitudinal analysis, we compared patients entering a clinical trial of buprenorphine in a Primary Care Clinic (PCC) and those entering a local Opioid Treatment Program (O...

    journal_title:Drug and alcohol dependence

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sullivan LE,Chawarski M,O'Connor PG,Schottenfeld RS,Fiellin DA

    更新日期:2005-07-01 00:00:00

  • Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol.

    abstract::Cannabis sativa (marijuana plant) contains myriad cannabinoid compounds; yet, investigative attention has focused almost exclusively on Delta(9)-tetrahydrocannabinol (THC), its primary psychoactive substituent. Interest in modulation of THC's effects by these other cannabinoids (e.g., cannabidiol (CBD)) has been stimu...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Vann RE,Gamage TF,Warner JA,Marshall EM,Taylor NL,Martin BR,Wiley JL

    更新日期:2008-04-01 00:00:00

  • Treatment of chronic cocaine abuse and attention deficit disorder, residual type, with magnesium pemoline.

    abstract::Research suggests that attention deficit disorder (ADD) may persist into adulthood, perhaps predisposing certain individuals to stimulant abuse. The authors describe two adults with chronic cocaine abuse and apparent residual ADD. After failing to respond to conventional treatment modalities, these patients were admin...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Weiss RD,Pope HG Jr,Mirin SM

    更新日期:1985-05-01 00:00:00

  • The Marijuana Ladder: measuring motivation to change marijuana use in incarcerated adolescents.

    abstract::The purpose of this study was to determine if a modified version of the Contemplation Ladder, a measure of motivation to change marijuana use among incarcerated adolescents (Marijuana Ladder; ML), was related to marijuana use and treatment engagement. Participants (N=122) in this study were all incarcerated at a state...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Slavet JD,Stein LA,Colby SM,Barnett NP,Monti PM,Golembeske C Jr,Lebeau-Craven R

    更新日期:2006-06-09 00:00:00

  • Early-onset of illicit substance use is associated with greater axis-II comorbidity, not with axis-I comorbidity.

    abstract::In the present study the relationship between early-onset (

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Franken IH,Hendriks VM

    更新日期:2000-06-01 00:00:00

  • Prescription drug misuse among homeless youth.

    abstract:BACKGROUND:Prescription drug misuse (PDM) is highly prevalent among youth in the U.S., and can have serious health consequences. Homeless youth are a particularly vulnerable population with high rates of substance use. However, PDM has not been studied in a sample comprised exclusively of homeless youth. METHODS:A sam...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Rhoades H,Winetrobe H,Rice E

    更新日期:2014-05-01 00:00:00

  • Is it feasible to pay specialty substance use disorder treatment programs based on patient outcomes?

    abstract:BACKGROUND:Some US payers are starting to vary payment to providers depending on patient outcomes, but this approach is rarely used in substance use disorder (SUD) treatment. PURPOSE:We examine the feasibility of applying a pay-for-outcomes approach to SUD treatment. METHODS:We reviewed several relevant literatures: ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审


    authors: Hodgkin D,Garnick DW,Horgan CM,Busch AB,Stewart MT,Reif S

    更新日期:2020-01-01 00:00:00

  • Educational disadvantage and cigarette smoking during pregnancy.

    abstract::This study examined the influence of education on smoking status in a cohort (n=316) of pregnant women who were smokers at the time they learned of the current pregnancy. Subjects were participants in clinical trials examining the efficacy of monetary-based incentives for smoking-cessation and relapse prevention. In m...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Higgins ST,Heil SH,Badger GJ,Skelly JM,Solomon LJ,Bernstein IM

    更新日期:2009-10-01 00:00:00

  • Clinical efficacy of buprenorphine: comparisons to methadone and placebo.

    abstract::Buprenorphine has been studied extensively since 1978 when it was initially proposed as an alternative to methadone for treatment of opioid dependence. Early work by Jasinski et al., 1978; Mello and Mendelson, 1980; Mello et al., 1982; Mello et al., 1983 and Mendelson et al., 1984 and their colleagues demonstrated bup...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审


    authors: Ling W,Wesson DR

    更新日期:2003-05-21 00:00:00

  • Follow-up study of subjects on methadyl acetate and methadone.

    abstract::Fifty of sixty original study subjects were assessed via two questionnaires and urinalysis tests between six months and one year following completion of the experimental program. Results indicate a high rate of retention in methadone/methadyl acetate treatment, and point to the need for positive social context, satisf...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章


    authors: Charuvastra VC,Panell J,Ling W,Ouren J

    更新日期:1980-11-01 00:00:00