Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers.

Abstract:

:The effects of cocaine were examined prior to and during bupropion maintenance in nonopioid-dependent cocaine abusers. Prior to bupropion maintenance, subjects underwent an experimental session during which repeated cocaine doses (0, 50, 100 mg/70 kg) were administered intranasally. Then subjects were maintained on bupropion (150 and 300 mg per day) and underwent experimental sessions as before. Cocaine, regardless of bupropion, produced dose-related increases in several stimulant-like self-reports, performance and cardiovascular measures. Bupropion decreased POMS ratings of friendliness and vigor, regardless of cocaine dose. Bupropion enhanced and attenuated cocaine-induced increases in ratings on the LSD and BG subscales of the ARCI, respectively. These results suggest that bupropion does not alter the acute subjective or cardiovascular effects of cocaine in a robust manner.

journal_name

Drug Alcohol Depend

authors

Oliveto A,McCance-Katz FE,Singha A,Petrakis I,Hameedi F,Kosten TR

doi

10.1016/s0376-8716(00)00198-8

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

155-67

issue

2

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(00)00198-8

journal_volume

63

pub_type

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