Abstract：
:Previous studies have demonstrated that administration of nonspecific opioid antagonists such as naltrexone or naloxone reduces ethanol-induced locomotor activity in mice. However, because of their broad pharmacological profile, it remains unclear through which opioid receptor this antagonism is achieved. Therefore, the present study was aimed at further investigating the role of the different opioid receptors in ethanol-induced (2.5 g/kg) locomotion in mice. First, we compared the effect of naltrexone (0-2 mg/kg) on ethanol-induced locomotion with that of the selective delta-opioid receptor antagonist, naltrindole (0-10 mg/kg). Results of this first set of data revealed that naltrexone completely blocked this effect of ethanol at doses suggested to occupy only mu-opioid receptors, and naltrindole did not modify ethanol-induced locomotion. In a second set of experiments, we further investigated the involvement of mu-opioid receptors in ethanol-stimulated motor activity by assessing the implication of mu(1)-, mu(1/2)-, and mu(3)-opioid receptor subtypes. Results revealed that mu(1/2)-, and to a lesser extent mu(3)-, but not mu(1)-opioid receptor subtypes are involved in the psychomotor actions of ethanol. Data are discussed together with previous results which have emphasized the critical dependence of ethanol-induced motor behaviors on opioid receptors, as well as, of the integrity of beta-endorphin synthesizing neurons from the hypothalamic Arcuate Nucleus.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Pastor R,Sanchis-Segura C,Aragon CMdoi
10.1016/j.drugalcdep.2004.11.007keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
289-95issue
3eissn
0376-8716issn
1879-0046pii
S0376-8716(04)00331-Xjournal_volume
78pub_type
杂志文章abstract：:The major objectives of the present study were 2-fold: (1) to demonstrate the superiority of receiver operating characteristic (ROC) methodology in the comparison of screening tests that yield continuous values; and (2) to identify the best screening indicator of current drug use disorders in alcoholics. We evaluated ...
journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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doi：10.1016/0376-8716(96)01238-0
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abstract：BACKGROUND:Ethanol and cocaine are widely abused drugs triggering long-lasting changes in neuronal circuits and synaptic transmission through the regulation of enzyme activity and gene expression. Compelling evidence indicates that the ubiquitin-proteasome system plays a role in the molecular changes induced by addicti...
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
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abstract：BACKGROUND:There is growing interest in the provision of parenting support to substance misusing parents. METHODS:This pragmatic, multi-center randomized controlled trial compared an intensive one-to-one parenting program (Parents under Pressure, PuP) with Treatment as Usual (TAU) in the UK. Parents were engaged in co...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:This study investigated the effects of a multi-level smoking intervention on mediators of long-term abstinence in parental smokers, including smoking cessation self-efficacy, smoking urge coping, and perceived support to quit smoking. METHODS:This is a secondary analysis of data from a randomized trial that...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2019.05.027
更新日期：2019-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2006.11.005
更新日期：2007-05-11 00:00:00
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doi：10.1016/j.drugalcdep.2020.107850
更新日期：2020-03-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.04.027
更新日期：2019-09-01 00:00:00
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journal_title：Drug and alcohol dependence
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doi：10.1016/j.drugalcdep.2014.08.017
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.02.022
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journal_title：Drug and alcohol dependence
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更新日期：1984-01-01 00:00:00
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journal_title：Drug and alcohol dependence
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abstract：:This study analyzes causes of deaths of 766 patients who died while in methadone treatment in Texas between 1994 and 2002. Compared with deaths in the general population of Texas, deaths of clients in methadone treatment were 4.6 times more likely to be from a drug overdose, 3.4 times more likely to be from liver dise...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2004.09.006
更新日期：2005-04-04 00:00:00
abstract：:In a sample survey of 712 Iranian male adolescents, aged 14-18, it was found that drugs users differed in only some of theirs beliefs about drug substances and their use from their non-drug-using contemporaries; and that both sub-samples had, in their agreement about the drug problem in post-revolutionary Iran, been e...
journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2013.10.027
更新日期：2014-01-01 00:00:00
abstract：:The purpose of this study was to examine the effects of smokeless tobacco (ST) brand switching on biomarkers of ST exposure and on ST use. Subjects seeking treatment to reduce their use were randomized to ST brand switching with controlled ST topography, brand switching with ad libitum ST use, or a waitlist control wi...
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2006.08.021
更新日期：2007-03-16 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.05.048
更新日期：2017-10-01 00:00:00
abstract：:Face validity in animal models of alcohol abuse and dependence is often at odds with robust demonstrations of ethanol-seeking. This study determined the relative influence of ethanol and a flavorant in maintaining ethanol intake in a nonhuman primate model of "cocktail" drinking. Four-year-old male monkeys were mainta...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.06.002
更新日期：2007-12-01 00:00:00
abstract：:The purpose of this cross-sectional study was to classify a sample of HIV-seropositive African-American crack cocaine smokers into homogenous HIV drug use and sexual risk groups using a two step multivariate cluster analysis. Two hundred and fifty-eight crack cocaine smokers participated in the study. Cluster analysis...
journal_title：Drug and alcohol dependence
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doi：10.1016/j.drugalcdep.2008.03.023
更新日期：2008-09-01 00:00:00
