Abstract：
BACKGROUND:There is growing interest in the provision of parenting support to substance misusing parents. METHODS:This pragmatic, multi-center randomized controlled trial compared an intensive one-to-one parenting program (Parents under Pressure, PuP) with Treatment as Usual (TAU) in the UK. Parents were engaged in community-based substance misuse services and were primary caregivers of children less than 2.5 years of age. The primary outcome was child abuse potential, and secondary outcomes included measures of parental emotional regulation assessed at baseline, 6 and 12-months. A prospective economic evaluation was also conducted. RESULTS:Of 127 eligible parents, 115 met the inclusion criteria, and subsequently parents were randomly assigned to receive PuP (n = 48) or TAU (n = 52). Child abuse potential was significantly improved in those receiving the PuP program while those in TAU showed a deterioration across time in both intent-to-treat (p < 0.03) and per-protocol analyses (p < 0.01). There was also significant reliable change (recovery/improvement) in 30.6% of the PuP group compared with 10.3% of the TAU group (p < 0.02), and deterioration in 3% compared with 18% (p < 0.02). The probability that the program is cost-effective was approximately 51.8% if decision-makers are willing to pay £1000 for a unit improvement in the primary outcome, increasing to 98.0% at a £20,000 cost-effectiveness threshold for this measure. CONCLUSIONS:Up to one-third of substance dependent parents of children under 3-years of age can be supported to improve their parenting, using a modular, one-to-one parenting program. Further research is needed.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Barlow J,Sembi S,Parsons H,Kim S,Petrou S,Harnett P,Dawe Sdoi
10.1016/j.drugalcdep.2018.08.044subject
Has Abstractpub_date
2019-01-01 00:00:00pages
184-194eissn
0376-8716issn
1879-0046pii
S0376-8716(18)30771-3journal_volume
194pub_type
杂志文章,随机对照试验abstract：BACKGROUND:The theoretical benefits of naltrexone as a treatment for opioid use disorder (e.g., safety, non-addictive, low risk of diversion) stand in sharp contrast to its disappointing record on retention in most samples. The relationship of uncomfortable physical and dysphoric symptoms to retention on naltrexone is ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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abstract：BACKGROUND:To describe all-cause and cause-specific mortality in a cohort of people who had ever injected drugs (PWID) with a low prevalence of HIV over 20-30 years. METHODS:Using a retrospective study design, identifying data from a cohort of PWID recruited between 1982 and 1993 through in-patient drug treatment serv...
journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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abstract：:A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(81)90103-4
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2007.06.011
更新日期：2008-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2007-10-08 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.05.008
更新日期：2011-11-01 00:00:00
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析,评审
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更新日期：2006-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.07.003
更新日期：2016-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(94)90076-0
更新日期：1994-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2019.107770
更新日期：2020-02-01 00:00:00
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journal_title：Drug and alcohol dependence
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更新日期：2003-03-01 00:00:00
