Abstract：
AIMS:The aims of the present study were to determine the direct effect of DRD2 and DRD4, as well as their interaction with parenting (i.e. rejection, overprotection and emotional warmth), on the development of regular alcohol and cannabis use in 1192 Dutch adolescents from the general population. METHODS:Information was obtained by self-report questionnaires. Perceived rejection, overprotection and emotional warmth were assessed at age 10-12. Regular alcohol and cannabis use were determined at age 15-18 and defined as the consumption of alcohol on 10 or more occasions in the past four weeks, and the use of cannabis on 4 or more occasions in the past four weeks. Models were adjusted for age, sex, parental alcohol or cannabis use, and externalizing behavior. RESULTS:Carrying the A1 allele of the DRD2 TaqIA polymorphism, or the 7 repeat DRD4, was not directly related to regular alcohol or cannabis use. In addition, adolescent carriers of these genetic risk markers were not more susceptible to the influence of less optimal parenting. Main effects for parenting indicated that overprotection increased the risk of regular alcohol use, whereas the risk of cannabis use was enhanced by parental rejection and buffered by emotional warmth. CONCLUSIONS:Our findings do not support an association between DRD2/DRD4 and regular alcohol and cannabis use in adolescents. Given the substance-specific influences of rejection, overprotection and emotional warmth, these parenting factors might be promising candidates for prevention work.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Creemers HE,Harakeh Z,Dick DM,Meyers J,Vollebergh WA,Ormel J,Verhulst FC,Huizink ACdoi
10.1016/j.drugalcdep.2010.10.008subject
Has Abstractpub_date
2011-05-01 00:00:00pages
35-42issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(10)00360-1journal_volume
115pub_type
杂志文章abstract：:The level of norepinephrine (NE), epinephrine (E) and dopamine (DA) in hypothalamus and blood plasma along with antibodies to NE, DA and serotonin (5-HT) and characteristics of alpha 1-, alpha 2-adrenergic, D2-dopaminergic and S2-serotoninergic receptors in synaptic brain membranes were studied in two groups of rats p...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(92)90063-i
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVE:Examined effects of prenatal cocaine exposure (PCE) on tobacco, alcohol, marijuana and cocaine use by age 15. METHODS:Adolescent (n=358; 183 PCE, 175 non-prenatally cocaine exposed; NCE) drug use was assessed using urine, hair, and/or blood spot samples and self-report (Youth Risk Behavior Surveillance Syste...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Drug and alcohol dependence
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更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:The opioid epidemic is one of the greatest public health crises of our times, driven increasingly by synthetic opioids such as fentanyl in the heroin supply. The implementation of drug checking in community settings has the potential to reduce the burden of fatal overdose, provide harm reduction education ar...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.10.017
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:This paper presents a systematic review and meta-analysis of available evidence on remission rates for substance use disorders (SUDs), providing weighted mean estimates of SUD remission rates. The review also explores study-level characteristics that may explain variations in remission rates across studies. ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. ...
journal_title：Drug and alcohol dependence
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更新日期：2017-09-01 00:00:00
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journal_title：Drug and alcohol dependence
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更新日期：2016-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：1985-05-01 00:00:00
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更新日期：1994-03-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-08-02 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.01.016
更新日期：2011-09-01 00:00:00
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更新日期：1979-05-01 00:00:00
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更新日期：1983-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2020-03-23 00:00:00
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更新日期：1986-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2008.03.017
更新日期：2008-09-01 00:00:00
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更新日期：2001-11-01 00:00:00
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更新日期：2012-09-01 00:00:00
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更新日期：2007-07-10 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.02.022
更新日期：2011-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(84)90027-9
更新日期：1984-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.12.020
更新日期：2014-03-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(84)90067-x
更新日期：1984-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2009-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2009.08.002
更新日期：2010-01-15 00:00:00
abstract：BACKGROUND:Research has indicated associations between risky alcohol consumption and sexual risk behavior, which may in turn present risk of HIV acquisition or transmission. Little is known about social determinants of problematic alcohol use among African American MSM (AA MSM), a risk group disproportionately affected...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.10.002
更新日期：2014-01-01 00:00:00
