Serum brain-derived neurotrophic factor and nerve growth factor decreased in chronic ketamine abusers.

Abstract:

AIMS:This study investigated the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in a group of chronic ketamine abusers in comparison to healthy controls. The correlations between the serum BDNF, NGF level with the subjects' demographic, pattern of ketamine use were also examined. METHODS:93 subjects who met the criteria of ketamine dependence and 39 healthy subjects were recruited. Serum BDNF and NGF levels were assayed by enzyme-linked immunosorbent assay (ELISA). Psychopathological symptoms were assessed using Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). RESULTS:Both serum levels of BDNF and NGF were significant lower in the ketamine users compared to the healthy control subjects (9.50±6.68 versus 14.37±6.07 ng/ml, p=0.019 for BDNF; 1.93±0.80 versus 2.60±1.07 ng/ml, p=0.011 for NGF). BDNF level was negatively associated with current frequency of ketamine use (r=-0.209, p=0.045). CONCLUSIONS:Both BDNF and NGF serum concentrations were significantly lower among chronic ketamine users than among health controls.

journal_name

Drug Alcohol Depend

authors

Ke X,Ding Y,Xu K,He H,Zhang M,Wang D,Deng X,Zhang X,Zhou C,Liu Y,Ning Y,Fan N

doi

10.1016/j.drugalcdep.2014.06.043

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

290-4

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(14)00970-3

journal_volume

142

pub_type

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