Abstract:
AIMS:This study investigated the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in a group of chronic ketamine abusers in comparison to healthy controls. The correlations between the serum BDNF, NGF level with the subjects' demographic, pattern of ketamine use were also examined. METHODS:93 subjects who met the criteria of ketamine dependence and 39 healthy subjects were recruited. Serum BDNF and NGF levels were assayed by enzyme-linked immunosorbent assay (ELISA). Psychopathological symptoms were assessed using Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). RESULTS:Both serum levels of BDNF and NGF were significant lower in the ketamine users compared to the healthy control subjects (9.50±6.68 versus 14.37±6.07 ng/ml, p=0.019 for BDNF; 1.93±0.80 versus 2.60±1.07 ng/ml, p=0.011 for NGF). BDNF level was negatively associated with current frequency of ketamine use (r=-0.209, p=0.045). CONCLUSIONS:Both BDNF and NGF serum concentrations were significantly lower among chronic ketamine users than among health controls.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Ke X,Ding Y,Xu K,He H,Zhang M,Wang D,Deng X,Zhang X,Zhou C,Liu Y,Ning Y,Fan Ndoi
10.1016/j.drugalcdep.2014.06.043subject
Has Abstractpub_date
2014-09-01 00:00:00pages
290-4eissn
0376-8716issn
1879-0046pii
S0376-8716(14)00970-3journal_volume
142pub_type
杂志文章abstract:BACKGROUND:Both cannabis use and alcohol use are elevated among people living with HIV, but few studies have investigated the relationship between cannabis use and alcohol use in this population. This study examined the longitudinal association between cannabis use and alcohol use among people living with HIV and explo...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.08.026
更新日期:2018-12-01 00:00:00
abstract::The intersection of drug use, violence, and depression with HIV-risk among African American women is an under explored area of research. The current analyses examine whether particular sexual risk behaviors are associated with exposure to violence, depression or both among 420 African American out-of-treatment female ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(02)00345-9
更新日期:2003-05-21 00:00:00
abstract:BACKGROUND:The theoretical benefits of naltrexone as a treatment for opioid use disorder (e.g., safety, non-addictive, low risk of diversion) stand in sharp contrast to its disappointing record on retention in most samples. The relationship of uncomfortable physical and dysphoric symptoms to retention on naltrexone is ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2018.08.019
更新日期:2018-11-01 00:00:00
abstract::Individuals with co-occurring substance use and psychiatric disorders have a more severe clinical course and poorer outcomes than do individuals with one disorder. In an attempt to find intervening variables that may contribute to improvement in treatment outcomes among individuals with co-occurring disorders, we inve...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.01.009
更新日期:2007-07-10 00:00:00
abstract:AIM:To evaluate potential mediators of an extended cognitive behavioral smoking cessation intervention. DESIGN:Analysis of data from a randomized clinical trial of smoking cessation. SETTING:The Habit Abatement Clinic, University of California, San Francisco. PARTICIPANTS:Participants were older cigarette smokers (>...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2009.12.021
更新日期:2010-06-01 00:00:00
abstract::Premature termination of treatment by the client has been a pervasive problem in the alcohol treatment field. This drop-out problem is compounded in conjoint therapy for alcoholic couples since most clients typically do not view the drinking problem from a systemic, interactional perspective. Within a short-term commu...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(83)90023-6
更新日期:1983-06-01 00:00:00
abstract::Hazardous drinking is prevalent among college students, yet few seek treatment. Anxiety sensitivity AS is one factor with relevance to drinking. Yet, there are no known estimates of the prevalence of elevated AS among hazardous drinkers. The current study sought to estimate the prevalence of elevated AS among hazardou...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107922
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Health and social impacts of safe consumption sites (SCS) are well described in multiple countries. One argument used by those opposed to SCS in the US is that findings from other countries are not relevant to the US context. We examined whether an unsanctioned SCS operating in the US affected local crime ra...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2021.108521
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:Previous research has demonstrated how negative affect (i.e., depression, anxiety, stress) is often a correlate of and precursor to nicotine dependence. Although recent evidence shows a gradual decline in tobacco use in the United States, subgroups that report higher levels of negative affect may continue to...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107883
更新日期:2020-04-01 00:00:00
abstract::The use of smoked marijuana as a therapeutic agent is presently a matter of considerable debate in the United States. Many people suffering from a variety of disorders maintain that it is necessary for their adequate treatment. Yet, the evidence to support claims is insufficient for FDA approval. An interim solution i...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(99)00076-9
更新日期:2000-02-01 00:00:00
abstract::Serum alcohol dehydrogenase (ADH) activity in some individuals contains a fraction that is not inhibited by pyrazole. This might be due to the presence in those sera of pi-ADH, a unique isoenzyme found recently in human liver, and which, according to one hypothesis, could be co-responsible for the development of alcoh...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(80)90457-3
更新日期:1980-09-01 00:00:00
abstract::Peripheral and autonomic neuropathy has been evaluated, both by clinical and neurophysiological and by clinical methods, respectively, in 33 alcoholics, 20 of them cirrhotics. Nerve dysfunction was compared with liver function parameters, the Child-Pugh score, and parameters derived from ethanol consumption. Few relat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(91)90004-i
更新日期:1991-05-01 00:00:00
abstract:AIMS:The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is a screening instrument to detect substance use in primary care (PC). To screen for illicit substances (excluding tobacco and alcohol), the ASSIST consists of 8-57 questions and requires complicated scoring. To improve the efficiency of scree...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.03.029
更新日期:2016-07-01 00:00:00
abstract::There has been a considerable increase in the number of intravenous amphetamine misusers during the last decade, and the development of effective treatment strategies for this high-risk group has become critical. The use of substitute prescribing is one option, but reservations have been expressed as to its demonstrat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00052-0
更新日期:1998-09-01 00:00:00
abstract::Alcohol is a known suppressant of the immune system and alcoholics frequently have impaired humoral and cell-mediated immunity. The purpose of this study was to investigate the effect of a single dose of ethanol on the thymus and the possible mechanism of its action. Adult female Wistar rats were divided into three gr...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(92)90024-7
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Studies of drinking drivers in alcohol-related crashes have shown that high breath-alcohol concentrations (BrACs) are associated with illegal drug use. Until the 2007 National Roadside Survey (NRS), the prevalence of drugs among drinking drivers on U.S. roads was unknown. Using NRS data, we explore how many ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.11.007
更新日期:2013-06-01 00:00:00
abstract:AIMS:The primary aim of the present study is to determine the one year periodic prevalence of dispension of different analgesics to patients in long term opioid maintenance therapy (OMT). The secondary aim is to determine to which extent non-opioid analgesics are used as first line analgesics. DESIGN:The study is a ph...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.12.014
更新日期:2011-07-01 00:00:00
abstract::In this paper, we examine the effects of age at first substance use, and history of psychiatric disorders, on the development of substance use disorder (SUD) by age 16. We use a prospective, longitudinal design to disaggregate the effects of age at first use and time since first use on the development of adolescent SU...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2004.03.013
更新日期:2004-09-06 00:00:00
abstract:OBJECTIVE:To investigate the association of major depressive episode (MDE) with nonmedical prescription opioid use (NMPOU) and opioid abuse/dependence among adolescents aged 12 to 17. METHODS:We analyzed 5 years of data from the National Survey on Drug Use and Health (NSDUH). We used logistic regressions to study the ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.04.010
更新日期:2015-07-01 00:00:00
abstract::This study compared urinary 5-hydroxytryptophol (5HTOL) with breath-ethanol testing as objective ways to disclose recent drinking by outpatients attending a methadone maintenance treatment clinic. Information about quantity and frequency of alcohol use was obtained by confidential self-reports. Random screening was pe...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(99)00007-1
更新日期:1999-08-02 00:00:00
abstract:BACKGROUND:Approximately 700,000 Social Security beneficiaries in the U.S. with psychiatric disabilities have been assigned a representative payee to manage their funds but it is unclear how those judged to need a payee differ from others and whether payee assignment improves clinical outcomes, especially substance abu...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.05.026
更新日期:2007-01-12 00:00:00
abstract:BACKGROUND:The Fagerström test for nicotine dependence (FTND) has been widely used in clinical samples but seldom in population samples. Data are particularly lacking for a large range of ages. The goal was to describe the FTND sum score distribution in the adult population and to show potential variation according to ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(03)00038-3
更新日期:2003-07-20 00:00:00
abstract:BACKGROUND:Cannabis withdrawal is not recognized in DSM-IV because of doubts about its clinical significance. OBJECTIVES:Assess the phenomenon of cannabis withdrawal and its relationship to relapse in non-treatment-seeking adults. SUBJECTS:Convenience sample of 469 adult cannabis smokers who had made a quit attempt w...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.04.010
更新日期:2010-09-01 00:00:00
abstract::During the academic year 1983-1984, a survey on drug consumption was conducted among medical students in Barcelona. There was a high proportion of smokers in both sexes. Alcohol consumption was four times higher among men than women; high proof beverages were becoming the most common drinks. Coffee was the caffeine dr...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(86)90062-1
更新日期:1986-11-01 00:00:00
abstract::While the centrality of withdrawal in the diagnosis of addiction has been decreasing with each successive edition of the Diagnostic and Statistical Manual of Mental Disorders, psychometric and neurobiological evidence provides withdrawal a central role in the development and maintenance of addiction. The current study...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107815
更新日期:2020-03-01 00:00:00
abstract::To replicate a Canada Health Survey (CHS) study that found beer drinking was associated with lower morbidity, National Health Interview Survey (NHIS) data for 19,462 persons were used to examine associations between functional disability and beverage specific ethanol consumption. A functional disability index consisti...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(90)90151-4
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:This study investigated the effects of a multi-level smoking intervention on mediators of long-term abstinence in parental smokers, including smoking cessation self-efficacy, smoking urge coping, and perceived support to quit smoking. METHODS:This is a secondary analysis of data from a randomized trial that...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.05.027
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To determine HIV prevalence and potential associations with sociodemographic and behavioral factors among injection drug users (IDUs) in Tashkent, Uzbekistan. METHODS:Subjects in this cross-sectional study provided sociodemographic and risk behavior data and were tested for HIV antibody with a saliva-based ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(06)80003-7
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:The number of admissions to addiction treatment centers in the Netherlands for gamma hydroxybutyrate (GHB) dependence is rapidly growing. Until now, treatment seeking GHB users have hardly been studied. This study characterizes inpatients in treatment for GHB dependence in terms of sociodemographics, motives...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2012.12.023
更新日期:2013-08-01 00:00:00
abstract::Self-reports of drug use frequency are central to treatment outcome evaluations, estimates of the prevalence of heavy use, estimates of treatment need, and other questions with direct relevance to drug policies. Nevertheless, surprisingly little is known about the validity of these self-reports. This study examines th...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(99)00048-4
更新日期:2000-01-01 00:00:00