Abstract：
:Recent evidence suggests that individuals with opiate dependence may have cognitive dysfunctions particularly within the spectrum of executive functioning and emotional processing. Such dysfunctions can also compromise daily decisions associated with risk-taking behaviors. However, it remains unclear whether patients addicted to opiates show impaired decision-making on gambling tasks that specify explicit rules for rewards and punishments and provide information about probabilities associated with different long-term outcomes. In this study, we examined 18 individuals with opiate dependence and 18 healthy comparison subjects, matched for age, gender, and education with the Game of Dice Task (GDT). The GDT is a gambling task with explicit rules for gains and losses and fix winning probabilities. In addition, all subjects completed a neuropsychological test battery that primarily focused on executive functions and a personality questionnaire. On the GDT, patients chose the risky alternatives more frequently than the control group. Patients' GDT performance was related to executive functioning but not to other neuropsychological constructs, personality or dependence specific variables with one exception that is the number of days of abstinence. Thus, patients with opiate dependence demonstrate abnormalities in decision-making that might be neuropsychologically associated with dysfunctional behavior in patients' daily lives. Decision-making and other neuropsychological functioning should be considered in the treatment of opiate dependence.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Brand M,Roth-Bauer M,Driessen M,Markowitsch HJdoi
10.1016/j.drugalcdep.2008.03.017subject
Has Abstractpub_date
2008-09-01 00:00:00pages
64-72issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(08)00111-7journal_volume
97pub_type
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journal_title：Drug and alcohol dependence
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pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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