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Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study.

Abstract：

BACKGROUND:Functional neuroimaging studies have shown that specific brain areas are associated with alcohol craving including the dorsolateral prefrontal cortex (DLPFC). We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol dependence while being exposed to alcohol cues. METHODS:We performed a randomized sham-controlled study in which 13 subjects received sham and active bilateral tDCS delivered to DLPFC (anodal left/cathodal right and anodal right/cathodal left). For sham stimulation, the electrodes were placed at the same positions as in active stimulation; however, the stimulator was turned off after 30s of stimulation. Subjects were presented videos depicting alcohol consumption to increase alcohol craving. RESULTS:Our results showed that both anodal left/cathodal right and anodal right/cathodal left significantly decreased alcohol craving compared to sham stimulation (p<0.0001). In addition, we found that following treatment, craving could not be further increased by alcohol cues. CONCLUSIONS:Our findings showed that tDCS treatment to DLPFC can reduce alcohol craving. These findings extend the results of previous studies using noninvasive brain stimulation to reduce craving in humans. Given the relatively rapid suppressive effect of tDCS and the highly fluctuating nature of alcohol craving, this technique may prove to be a valuable treatment strategy within the clinical setting.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Boggio PS,Sultani N,Fecteau S,Merabet L,Mecca T,Pascual-Leone A,Basaglia A,Fregni F

doi

10.1016/j.drugalcdep.2007.06.011

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

55-60

issue

1-3

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(07)00250-5

journal_volume

92

pub_type

杂志文章,随机对照试验

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