Abstract：
BACKGROUND:Only in recent years have longitudinal studies of adolescents diagnosed alcohol use disorders and these have not distinguished between abuse and dependence. This study describes the course of disorder from age 18 to age 25 for abuse and dependence and investigates the extent to which continuities in disorder can be explained by background factors. METHODS:A birth cohort of 1,265 individuals from Christchurch, New Zealand, followed annually to age 16 years then at 18, 21 and 25 years (1,003 at age 25). DSM-IV diagnoses were made from reports of alcohol symptoms at 18, 21 and 25 years. RESULTS:The most stable diagnosis was that of no diagnosis, with 83-91% staying the same from one interview to the next. There were high rates of remission to no disorder; 57-75% for those with initial abuse and 50-54% of those with initial dependence. Nonetheless prior diagnosis was a strong predictor of subsequent diagnosis (ORs of 3.7-27.6). Adjustment for background risk factors reduced these odds ratios but all remained significant and substantial (minimum 2.6). CONCLUSIONS:The dual finding of substantial discontinuity and substantial continuity indicates that both public health and treatment interventions are warranted.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Wells JE,Horwood LJ,Fergusson DMdoi
10.1016/j.drugalcdep.2005.06.006keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
157-65issue
2eissn
0376-8716issn
1879-0046pii
S0376-8716(05)00196-1journal_volume
81pub_type
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