当前位置： SCI文献检索 > DRUG AND ALCOHOL DEPENDENCE期刊下所有文献 > Effects of acute combined serotonin and dopamine depletion on cue-induced drinking intention/desire and cognitive function in patients with alcohol dependence.

Effects of acute combined serotonin and dopamine depletion on cue-induced drinking intention/desire and cognitive function in patients with alcohol dependence.

Abstract：

BACKGROUND:Alcohol cues can precipitate the desire to drink and cause relapse in recovering alcohol-dependent patients. Serotonin and dopamine may play a role in alcohol cue-induced craving. Acute combined tryptophan (Trp), tyrosine (Tyr), and phenylalanine (Phe) depletion (CMD) in the diet attenuates the synthesis of serotonin and dopamine in the human brain. However, no study of the effects of acute CMD has been previously conducted. Therefore, we investigated whether the attenuation of serotonin and dopamine synthesis changes cue-induced alcohol craving in recently abstinent alcoholics. METHODS:In this double-blind, randomized, placebo-controlled, crossover design, 12 male patients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria for alcohol dependence were divided into two conditions: (1) monoamine depletion (i.e., consumption of a concentrated amino acid beverage that resulted in a rapid and significant decrease in plasma-free Tyr/Phe/Trp) and (2) balanced condition (i.e., consumption of a similar beverage that contained Tyr/Phe/Trp). The participants were scheduled for two experimental sessions, with an interval of ≥7 days. The cue-induced craving test session was conducted 6h after each amino acid beverage administration. Drinking urge, blood pressure, heart rate, working memory, and attention/psychomotor performance were assessed before and after administration. RESULTS:Compared with the balanced condition, the monoamine depletion condition significantly increased drinking intention/desire and diastolic blood pressure. Cognitive performance was not different between the two conditions. CONCLUSIONS:Acute combined serotonin and dopamine depletion may increase drinking intention/desire and diastolic blood pressure without influencing cognitive function.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Sun HQ,Liu Y,Li P,Bao YP,Sheng LX,Zhang RL,Cao YJ,Di XL,Yang FD,Wang F,Luo YX,Lu L

doi

10.1016/j.drugalcdep.2012.01.006

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

200-6

issue

3

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(12)00022-1

journal_volume

124

pub_type

杂志文章,随机对照试验

相关文献

DRUG AND ALCOHOL DEPENDENCE文献大全
  • Toxicological findings and manner of death in autopsied users of anabolic androgenic steroids.

    abstract：:With the aim to characterize patterns in toxicological profile and manner of death in deceased users of anabolic androgenic steroids (AAS), a retrospective autopsy protocol study of 52 deceased users of AAS was undertaken. The AAS users were compared to 68 deceased users of amphetamine and/or heroin who were consecuti...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2005.07.003

    authors： Petersson A,Garle M,Holmgren P,Druid H,Krantz P,Thiblin I

    更新日期：2006-02-28 00:00:00

  • Impact of ADHD and cannabis use on executive functioning in young adults.

    abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) and cannabis use are each associated with specific cognitive deficits. Few studies have investigated the neurocognitive profile of individuals with both an ADHD history and regular cannabis use. The greatest cognitive impairment is expected among ADHD Cannabis ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2013.08.001

    authors： Tamm L,Epstein JN,Lisdahl KM,Molina B,Tapert S,Hinshaw SP,Arnold LE,Velanova K,Abikoff H,Swanson JM,MTA Neuroimaging Group.

    更新日期：2013-12-01 00:00:00

  • Shifting characteristics of nonmedical prescription tranquilizer users in the United States, 2005-2014.

    abstract：BACKGROUND:Benzodiazepine overdose rates have increased in the US, largely from concomitant use of other drugs such as opioids. Studies are needed to examine trends in prescription tranquilizer (e.g., benzodiazepine) use-with a particular focus on use of other drugs such as opioids-to continue to inform prevention effo...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2018.11.015

    authors： Palamar JJ,Han BH,Martins SS

    更新日期：2019-02-01 00:00:00

  • Drug use related problems among nonmedical users of prescription stimulants: a web-based survey of college students from a Midwestern university.

    abstract：:This college-based study compared nonmedical users of prescription stimulants to other types of drug users regarding drug use related problems. A Web survey was self-administered in 2005 by a probability sample of 3639 full-time undergraduate students (68% response rate) at a large public Midwestern 4-year university ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2007.05.010

    authors： McCabe SE,Teter CJ

    更新日期：2007-11-02 00:00:00

  • Incidence and prevalence of hepatitis c virus infection among persons who inject drugs in New York City: 2006-2013.

    abstract：BACKGROUND:Hepatitis C virus infection is a source of significant preventable morbidity and mortality among persons who inject drugs (PWID). We sought to assess trends in hepatitis C virus (HCV) infection among PWID from 2006 to 2013 in New York City (NYC). METHODS:Annual cross-sectional surveys of PWID entering a lar...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2015.03.039

    authors： Jordan AE,Des Jarlais DC,Arasteh K,McKnight C,Nash D,Perlman DC

    更新日期：2015-07-01 00:00:00

  • Insomnia treatment in the context of alcohol use disorder: A systematic review and meta-analysis.

    abstract：PURPOSE:To determine the efficacy of behavioral and pharmacological interventions for insomnia among individuals with alcohol use disorder (AUD). PROCEDURES:Comprehensive literature searches of psychological, medical, and educational databases were conducted through October 2016. Eligible studies evaluated the efficac...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.drugalcdep.2017.09.029

    authors： Miller MB,Donahue ML,Carey KB,Scott-Sheldon LAJ

    更新日期：2017-12-01 00:00:00

  • Post-traumatic stress disorder and risk of prescription opioid use, over-use, and misuse among World Trade Center Health Registry enrollees, 2015-2016.

    abstract：BACKGROUND:Among veterans, post-traumatic stress disorder (PTSD) has been shown to be associated with the use and misuse of prescription opioids. Less is known about PTSD among the general population and PTSD resulting from non-combat related trauma. We sought to determine if PTSD following exposure to the World Trade ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107959

    authors： Takemoto E,Brackbill R,Martins S,Farfel M,Jacobson M

    更新日期：2020-05-01 00:00:00

  • Smokeless tobacco brand switching: a means to reduce toxicant exposure?

    abstract：:The purpose of this study was to examine the effects of smokeless tobacco (ST) brand switching on biomarkers of ST exposure and on ST use. Subjects seeking treatment to reduce their use were randomized to ST brand switching with controlled ST topography, brand switching with ad libitum ST use, or a waitlist control wi...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2006.08.021

    authors： Hatsukami DK,Ebbert JO,Anderson A,Lin H,Le C,Hecht SS

    更新日期：2007-03-16 00:00:00

  • Accumbens functional connectivity during reward mediates sensation-seeking and alcohol use in high-risk youth.

    abstract：BACKGROUND:Differences in fronto-striatal connectivity in problem substance users have suggested reduced influence of cognitive regions on reward-salience regions. Youth with a family history of alcoholism (FH+) have disrupted ventral striatal processing compared with controls with no familial risk (FH-). As sensation-...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2012.08.019

    authors： Weiland BJ,Welsh RC,Yau WY,Zucker RA,Zubieta JK,Heitzeg MM

    更新日期：2013-02-01 00:00:00

  • A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit.

    abstract：:Most smoking cessation programs advise abrupt rather than gradual cessation. We conducted a randomized, controlled trial of gradual cessation (n=297) vs. abrupt cessation (n=299) vs. minimal treatment (n=150) among smokers who wanted to quit now and preferred to quit gradually. Participants were recruited via newspape...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2010.04.007

    authors： Hughes JR,Solomon LJ,Livingston AE,Callas PW,Peters EN

    更新日期：2010-09-01 00:00:00

  • Retention in a low-threshold methadone maintenance program.

    abstract：:In 370 opioid-dependent patients included consecutively in a low-threshold methadone maintenance program, the effect of different variables on the retention rate was assessed. The variables included the patients' age, sex, family situation, employment status, length of heroin use, current route of drug consumption, pr...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(96)01230-6

    authors： Torrens M,Castillo C,Pérez-Solá V

    更新日期：1996-05-01 00:00:00

  • An evaluation of a behaviour therapy programme as an intervention treatment for the fear of withdrawal with heroin-dependent persons.

    abstract：:A methadone withdrawal programme (MWP) and a behaviour therapy programme (BTP) were compared in terms of their effectiveness to prevent relapse of heroin addicts after methadone treatment. The BTP incorporated systematic desensitization to effect a decrease in levels of fear of both physical and environmental withdraw...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(80)90193-3

    authors： Hollonds GB,Oei TP,Turecek LR

    更新日期：1980-02-01 00:00:00

  • Cognitive group therapy for wives of alcoholics--a pilot study.

    abstract：:This paper reports on the results of group therapy for the wives of alcoholics where the alcoholics themselves were offered no treatment. The reason for running such a group is based on the idea that wives might seek help before their husbands, might attend sessions regularly and by acquiring better knowledge of alcoh...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(86)90084-0

    authors： Farid B,el Sherbini M,Raistrick D

    更新日期：1986-07-01 00:00:00

  • The influence of partner drug use and relationship power on treatment engagement.

    abstract：:Substance-using intimate partners negatively influence individuals' substance abuse treatment engagement and drug use, but little else is known about effects of intimate relationships on treatment. We examine how relationship dynamics (power, control, dependence, insecurity and decision-making power) influence treatme...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(02)00332-0

    authors： Riehman KS,Iguchi MY,Zeller M,Morral AR

    更新日期：2003-05-01 00:00:00

  • The influence of discrimination on smoking cessation among Latinos.

    abstract：BACKGROUND:Although studies have shown a cross-sectional link between discrimination and smoking, the prospective influence of discrimination on smoking cessation has yet to be evaluated. Thus, the purpose of the current study was to determine the influence of everyday and major discrimination on smoking cessation amon...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.01.003

    authors： Kendzor DE,Businelle MS,Reitzel LR,Castro Y,Vidrine JI,Mazas CA,Cinciripini PM,Lam CY,Adams CE,Correa-Fernández V,Cano MÁ,Wetter DW

    更新日期：2014-03-01 00:00:00

  • Social relationships and intravenous drug use among methadone maintenance patients.

    abstract：:This study examined the extent to which social relationships were associated with continued injection drug use and needle sharing among 252 methadone maintenance patients. Logistic regression analyses indicated that drug use was highest among persons who had a substance using live-in partner and among those with more ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(00)00230-1

    authors： Gogineni A,Stein MD,Friedmann PD

    更新日期：2001-09-01 00:00:00

  • Barriers to seeking help for physicians with substance use disorder: A review.

    abstract：BACKGROUND:Substance use disorders (SUD) might concern as many as 8-15% of physicians. Previous studies suggest that self-diagnosis and self-medication are common practices among physicians. The aim of this review was to identify if barriers to seeking help and medical care for impaired physicians exist. We also aimed ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/j.drugalcdep.2019.04.004

    authors： Vayr F,Herin F,Jullian B,Soulat JM,Franchitto N

    更新日期：2019-06-01 00:00:00

  • Redressing the epidemics of opioid overdose and HIV among people who inject drugs in Central Asia: the need for a syndemic approach.

    abstract：BACKGROUND:Accumulating evidence suggests that opioid overdose and HIV infection are burgeoning intertwined epidemics among people who inject drugs (PWID) in Central Asia. To date, however, research on overdose and its associations with HIV risks among PWID in Central Asia remains virtually absent. This paper aims to p...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/j.drugalcdep.2013.07.017

    authors： Gilbert L,Primbetova S,Nikitin D,Hunt T,Terlikbayeva A,Momenghalibaf A,Ruziev M,El-Bassel N

    更新日期：2013-11-01 00:00:00

  • A simulative comparison of respondent driven sampling with incentivized snowball sampling--the "strudel effect".

    abstract：BACKGROUND:Respondent driven sampling (RDS) and incentivized snowball sampling (ISS) are two sampling methods that are commonly used to reach people who inject drugs (PWID). METHODS:We generated a set of simulated RDS samples on an actual sociometric ISS sample of PWID in Vilnius, Lithuania ("original sample") to asse...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2013.11.020

    authors： Gyarmathy VA,Johnston LG,Caplinskiene I,Caplinskas S,Latkin CA

    更新日期：2014-02-01 00:00:00

  • Social network correlates of self-reported non-fatal overdose.

    abstract：:The leading cause of death among heroin users is drug overdose. The present study examined the relationship between history of self-reported drug overdoses and social network characteristics among cocaine and opiate users. Data were from cross-sectional surveys administered from March 2001 through February 2003 as par...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2003.09.005

    authors： Latkin CA,Hua W,Tobin K

    更新日期：2004-01-07 00:00:00

  • Longitudinal associations between marijuana and cigar use in young adults.

    abstract：BACKGROUND:We assess the longitudinal associations between marijuana and cigar (little cigars and cigarillos [LCCs] and large cigars) use on subsequent initiation of marijuana and cigar use. METHODS:Data are from a cohort study of 2189 young adults recruited in fall 2010 from 11 colleges in the Southeast. We used disc...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107964

    authors： Cornacchione Ross J,Sutfin EL,Suerken C,Walker S,Wolfson M,Reboussin BA

    更新日期：2020-03-23 00:00:00

  • Drinking drivers and drug use on weekend nights in the United States.

    abstract：BACKGROUND:Studies of drinking drivers in alcohol-related crashes have shown that high breath-alcohol concentrations (BrACs) are associated with illegal drug use. Until the 2007 National Roadside Survey (NRS), the prevalence of drugs among drinking drivers on U.S. roads was unknown. Using NRS data, we explore how many ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2012.11.007

    authors： Voas RB,Lacey JH,Jones K,Scherer M,Compton R

    更新日期：2013-06-01 00:00:00

  • Impact of e-liquid flavors on e-cigarette vaping behavior.

    abstract：OBJECTIVE:The primary objective of this pilot study was to describe the impact of e-cigarette liquid flavors on experienced e-cigarette users' vaping behavior. METHODS:11 males and 3 females participated in a 3-day inpatient crossover study using e-cigarettes with strawberry, tobacco, and their usual brand e-liquid. N...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2018.04.032

    authors： St Helen G,Shahid M,Chu S,Benowitz NL

    更新日期：2018-08-01 00:00:00

  • Contingency management treatment in cocaine using methadone maintained patients with and without legal problems.

    abstract：BACKGROUND:Legal difficulties and cocaine use are prevalent in methadone maintenance patients, and they are related to one another, as well as to poor response to methadone treatment. Contingency management (CM) is efficacious for decreasing cocaine use, but the relation of CM treatment to criminal activities has rarel...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.08.014

    authors： Ginley MK,Rash CJ,Olmstead TA,Petry NM

    更新日期：2017-11-01 00:00:00

  • Prevalence, correlates, comorbidity, and age of onset of alcohol use disorders in adult males from five provinces in China.

    abstract：BACKGROUND:This study integrates data from high-quality mental health surveys in five provinces in China to examine the prevalence, demographic correlates, age of onset, and comorbidity of alcohol use disorder (AUD). METHODS:The five cross-sectional surveys initially screened a representative sample of 74,752 communit...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.drugalcdep.2016.12.026

    authors： Phillips MR,Cheng HG,Li X,Zhang J,Shi Q,Xu G,Song Z,Ding Z,Pang S

    更新日期：2017-04-01 00:00:00

  • Effects of ethanol in vitro on some parameters of the immune response.

    abstract：:The action of ethanol (ETH) on murine lymphocyte subpopulations and on human peripheral blood mononuclear cells (PBMC) stimulated in vitro by mitogens was studied. ETH caused a concentration-dependent decrease in DNA synthesis in the different murine cell types. ETH was more immunosuppressive for T lymphocytes than fo...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(89)90061-6

    authors： Levallois C,Rouahi N,Balmes JL,Mani JC

    更新日期：1989-12-01 00:00:00

  • A review of the effects of repeated administration of selected phenylethylamines.

    abstract：:Several phenylethylamines are under consideration for international control. The effects of repeated administration of these compounds, including tolerance, physical dependence and central nervous system (CNS) toxicity, are reviewed here. The compounds can be divided into two major chemical groups: those with substitu...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/0376-8716(86)90005-0

    authors： Woolverton WL

    更新日期：1986-06-01 00:00:00

  • Acute alcohol intake alters resting state functional connectivity of nucleus accumbens with pain-related corticolimbic structures.

    abstract：BACKGROUND:The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2019.107811

    authors： Boissoneault J,Stennett B,Robinson ME

    更新日期：2020-02-01 00:00:00

  • Pharmacotherapy of cerebral ischemia in cocaine dependence.

    abstract：:This paper will examine how cerebral perfusion deficits in cocaine abusers may be a target for pharmacotherapy. The review covers five areas: (1) cerebral ischemia and neuropsychological impairment in cocaine abusers, (2) neuroimaging evidence for cerebral perfusion defects in cocaine abusers, (3) mechanisms for cocai...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/s0376-8716(97)00158-0

    authors： Kosten TR

    更新日期：1998-01-01 00:00:00

  • Human spinal fluid methadone levels.

    abstract：:Cerebral spinal fluid (CSF) levels of methadone were measured in nine methadone maintenance patients requiring lumbar punctures for medical or surgical treatment. Concurrent serum methadone levels were also determined. The CSF concentration of methadone in all cases was a fraction of the corresponding serum level--ran...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(78)90022-4

    authors： Rubenstein RB,Kreek MJ,Mbawa N,Wolff WI,Korn R,Gutjahr CL

    更新日期：1978-03-01 00:00:00