Abstract：
BACKGROUND:The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake affects resting state functional connectivity (rsFC) between the nucleus accumbens (NAc) and these regions will improve mechanistic understanding of alcohol's neurobehavioral effects, including the neural overlap between acute alcohol effects and pain processing. METHODS:Fifteen healthy social drinkers (10 women; age: 25-45 years) were included in the study. Participants completed one session in which they consumed an alcohol dose targeting a breath alcohol concentration of 0.08 g/dL, and in a second a placebo beverage. Nine-minute resting state fMRI scans were acquired 30-35 min after beverage administration during each session. rsFC between NAc and a priori corticolimbic regions of interest (mPFC, amgydala, and insula), were compared between beverage conditions. We also conducted an exploratory whole-brain seed-to-voxel analysis of NAc FC. RESULTS:Alcohol intake reduced rsFC between NAc and mPFC, as well as NAc and amygdala. Alcohol also reduced rsFC between NAc and a 97-voxel cluster including bilateral paracingulate cortex and anterior cingulate cortex. CONCLUSIONS:Findings suggest that acute alcohol intake reduces rsFC between NAc and several structures, including mPFC, amygdala, and rostral ACC in healthy social drinkers. These structures underlie reward, motivated behavior, and emotion regulation, and may provide mechanistic insight to how alcohol affects related processes, including pain.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Boissoneault J,Stennett B,Robinson MEdoi
10.1016/j.drugalcdep.2019.107811subject
Has Abstractpub_date
2020-02-01 00:00:00pages
107811eissn
0376-8716issn
1879-0046pii
S0376-8716(19)30588-5journal_volume
207pub_type
杂志文章abstract：:This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factor...
journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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更新日期：2018-12-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2015.11.019
更新日期：2016-03-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(80)90195-7
更新日期：1980-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.02.006
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.11.016
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.05.003
更新日期：2018-08-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2014-07-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.07.003
更新日期：2008-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2021-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.05.008
更新日期：2011-11-01 00:00:00
abstract：:An elevated rate of alcohol problems is believed to exist in the gay and lesbian community. However, prevalence estimates suggesting this have generally been based on convenience samples which have over-represented bar patrons and clinical sources. Recent epidemiological studies examining risk factors for AIDS have ga...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(93)90112-4
更新日期：1993-10-01 00:00:00
