Abstract:
AIMS:Though the introduction of office-based buprenorphine has greatly contributed to stem the HIV epidemic since 1995, concerns have been raised about the intravenous use of buprenorphine even in patients on substitution treatment. The aim of this study was to identify which factors are predictive of buprenorphine injection in patients receiving office-based buprenorphine. DESIGN AND SETTING:Subazur is a survey consisting of two longitudinal assessments of 111 stabilized patients receiving office-based buprenorphine in southeastern France. MEASUREMENTS:Patients were interviewed by phone at enrolment and 6 months later about social characteristics, addictive behaviors, treatment experiences, overdoses and suicide ideation or attempt. A logistic regression based on generalized estimating equations (GEE) was used to identify factors associated with buprenorphine injection at any interview. FINDINGS:Among the 111 patients (32% women, mean age 38 years), 36 reported buprenorphine injection after having started treatment initiation in 40 interviews. After adjustment for time since first injection, individuals perceiving their prescribed dosage as inadequate (OR=2.6 95%CI[1.2-5.7]) and those reporting a history of suicide ideation or attempt (OR=2.7 95%CI[1.1-7.0]) had approximately a three-fold higher risk of injecting buprenorphine. CONCLUSIONS:Providing adequate care for both drug dependence and psychiatric comorbidities in primary care is a major issue. Like heroin use during methadone treatment, buprenorphine injection should be regarded more as a response to inadequate care than simply as a "misuse". A re-assessment of the treatment efficacy through a possible dosage increase or a switch to methadone could potentially reduce diversion and assure sustained adherence to OST.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Roux P,Villes V,Blanche J,Bry D,Spire B,Feroni I,Carrieri MPdoi
10.1016/j.drugalcdep.2008.03.025subject
Has Abstractpub_date
2008-09-01 00:00:00pages
105-13issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(08)00119-1journal_volume
97pub_type
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2004.08.010
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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更新日期:1993-02-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Drug and alcohol dependence
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更新日期:2019-01-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.10.010
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Surgical ablation of select brain areas has been frequently used to alleviate psychological dependence on opiate drugs in certain countries. However, ablative brain surgery was stopped in China in 2004 due to the related ethical controversy and possible side effects. Deep brain stimulation (DBS), a less inva...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.09.012
更新日期:2013-04-01 00:00:00
abstract::Behavioral and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (1) by i.p. injection of increasing doses of the drug; (2) by i.p. injection of morphine as a reward o...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1986-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2006.03.019
更新日期:2006-12-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.10.032
更新日期:2017-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:2017-11-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2009.11.020
更新日期:2010-06-01 00:00:00
abstract::A sample of 200 injecting drug users were interviewed about their bodily injection sites. The mean number of injection sites ever used by subjects was 3.1, with a mean of 2.0 sites used in the previous 6 months. Sixteen percent of subjects had injected in five or more sites. Almost all (99%) had injected in the cubita...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00