当前位置： SCI文献检索 > DRUG AND ALCOHOL DEPENDENCE期刊下所有文献 > Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.

Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.

Abstract：

OBJECTIVE:To conduct a 16-week, randomized, placebo-controlled, double-blind trial of two GABAergic medications, baclofen (20 mg tid) and gabapentin (800 mg tid), for the treatment of methamphetamine dependence. METHODS:Adults with methamphetamine dependence were randomized to one of three conditions for 16 weeks: baclofen (n = 25), gabapentin (n = 26) or placebo (n = 37). All participants attended clinic thrice weekly to receive study medication and psychosocial counseling, complete study assessments, and provide urine samples. RESULTS:No statistically significant main effects for baclofen or gabapentin in reducing methamphetamine use were observed using a generalized estimating equation (GEE). A significant treatment effect was found in post hoc analyses for baclofen, but not gabapentin, relative to placebo among participants who reported taking a higher percentage of study medication (significant treatment group and medication adherence interaction in GEE model of methamphetamine use). CONCLUSIONS:While gabapentin does not appear to be effective in treating methamphetamine dependence, baclofen may have a small treatment effect relative to placebo. Future studies evaluating the effectiveness of baclofen and other GABAergic agents for treatment of methamphetamine may be warranted.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Heinzerling KG,Shoptaw S,Peck JA,Yang X,Liu J,Roll J,Ling W

doi

10.1016/j.drugalcdep.2006.03.019

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

177-84

issue

3

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(06)00164-5

journal_volume

85

pub_type

杂志文章,随机对照试验

相关文献

DRUG AND ALCOHOL DEPENDENCE文献大全
  • Effects of 6-hydroxydopamine or 5,7-dihydroxy-tryptamine on the development of physical dependence on ethanol.

    abstract：:Infant rats, treated intracisternally with 6-hydroxydopamine or 5,7-dihydroxytryptamine, alone or in combination with desmethylimipramine or pargyline, at 5 to 7 days of age, had significant specific depletions of brain norepinephrine, dopamine, both of these amines, or serotonin at 2.5 months of age. Despite apparent...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(77)90037-0

    authors： Frye GD,Ellis FW

    更新日期：1977-09-01 00:00:00

  • Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?

    abstract：OBJECTIVES:We characterize cannabinoid disposition in oral fluid (OF) after dronabinol, synthetic oral Δ(9)-tetrahydrocannabinol (THC), and Sativex, a cannabis-extract oromucosal spray, and evaluate whether smoked cannabis relapse or Sativex compliance can be identified with OF cannabinoid monitoring. METHODS:5 and 15...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2012.10.011

    authors： Lee D,Karschner EL,Milman G,Barnes AJ,Goodwin RS,Huestis MA

    更新日期：2013-06-01 00:00:00

  • Flavor-specific enhancement of electronic cigarette liquid consumption and preference in mice.

    abstract：BACKGROUND:The use of electronic cigarettes has increased over the past decade. To determine how the abuse liability of electronic cigarette liquids (e-liquids) differs from nicotine alone, and to determine the impact of flavor, we compared nicotine-containing fruit- and tobacco-flavored e-liquids, and their nicotine-f...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107995

    authors： Wong AL,McElroy SM,Robinson JM,Mulloy SM,El Banna FK,Harris AC,LeSage MG,Lee AM

    更新日期：2020-06-01 00:00:00

  • An internet-based abstinence reinforcement smoking cessation intervention in rural smokers.

    abstract：:The implementation of cigarette smoking abstinence reinforcement programs may be hindered by the time intensive burden placed on patients and treatment providers. The use of remote monitoring and reinforcement of smoking abstinence may enhance the accessibility and acceptability of this intervention, particularly in r...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2009.06.010

    authors： Stoops WW,Dallery J,Fields NM,Nuzzo PA,Schoenberg NE,Martin CA,Casey B,Wong CJ

    更新日期：2009-11-01 00:00:00

  • Propylhexdrine.

    abstract：:Propylhexedrine, a sympathomimetic with varied medicinal uses, is one of the compounds to be reviewed by the Expert Committee convened by the World Health Organization (WHO) to determine whether the compound should be scheduled under the Convention on Psychotropic Substances. This paper reviews the pharmacology, medic...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(86)90013-x

    authors： Wesson DR

    更新日期：1986-06-01 00:00:00

  • Substance use patterns and health profiles among US adults who use opioids, methamphetamine, or both, 2015-2018.

    abstract：BACKGROUND:Methamphetamine use, with and without opioids, has increased substantially, but little is known about the sociodemographic characteristics, substance use patterns, or health profiles of individuals who use methamphetamine. To design effective public health interventions, health care professionals and policym...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.108162

    authors： Shearer RD,Howell BA,Bart G,Winkelman TNA

    更新日期：2020-09-01 00:00:00

  • Rearrest rates among Norwegian drugged drivers compared with drunken drivers.

    abstract：:The rearrest rates among Norwegian drugged (n=1102) and a group of drunken drivers (n=850) (BAC: 0.16-0.19%) apprehended during 1992, were 57% (n=629) and 28% (n=238), respectively, when followed prospectively for 7 years. The most important risk factors for recidivism among drugged drivers were previous arrests for d...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(01)00187-9

    authors： Christophersen AS,Skurtveit S,Grung M,Mørland J

    更新日期：2002-03-01 00:00:00

  • A comparison of alcohol consumption between lesbians and heterosexual women in an urban population.

    abstract：:An elevated rate of alcohol problems is believed to exist in the gay and lesbian community. However, prevalence estimates suggesting this have generally been based on convenience samples which have over-represented bar patrons and clinical sources. Recent epidemiological studies examining risk factors for AIDS have ga...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(93)90112-4

    authors： Bloomfield K

    更新日期：1993-10-01 00:00:00

  • Is ecstasy a drug of dependence?

    abstract：:This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factor...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/j.drugalcdep.2009.09.009

    authors： Degenhardt L,Bruno R,Topp L

    更新日期：2010-02-01 00:00:00

  • Effects of ethanol in vitro on some parameters of the immune response.

    abstract：:The action of ethanol (ETH) on murine lymphocyte subpopulations and on human peripheral blood mononuclear cells (PBMC) stimulated in vitro by mitogens was studied. ETH caused a concentration-dependent decrease in DNA synthesis in the different murine cell types. ETH was more immunosuppressive for T lymphocytes than fo...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(89)90061-6

    authors： Levallois C,Rouahi N,Balmes JL,Mani JC

    更新日期：1989-12-01 00:00:00

  • Discrepancies in addressing overdose prevention through prescription monitoring programs.

    abstract：BACKGROUND:State prescription monitoring programs (PMPs) purport to address the prescription opioid epidemic, but have evidenced limited effect on reducing opioid-related mortality. METHODS:We systematically reviewed publicly available, PMP web-based materials from December, 2012 to October, 2013, to assess the degree...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2015.05.009

    authors： Green TC,Bowman S,Davis C,Los C,McHugh K,Friedmann PD

    更新日期：2015-08-01 00:00:00

  • Predictors of positive drinking outcomes among youth receiving an alcohol brief intervention in the emergency department.

    abstract：BACKGROUND:Reducing underage drinking is a public health priority given increased risk for injury and other consequences. Emergency department (ED) visits offer a potential "teachable moment" to initiate interventions among youth engaged in risky drinking. Given mixed findings for alcohol brief interventions (BIs), thi...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2018.03.044

    authors： Davis AK,Arterberry BJ,Bonar EE,Chermack ST,Blow FC,Cunningham RM,Walton MA

    更新日期：2018-07-01 00:00:00

  • Detecting smoking following smoking cessation treatment.

    abstract：:Our study compared the results of self-report (SR) plus breath carbon monoxide (CO) monitoring to SR plus urine cotinine (COT) analysis of recent tobacco use for a recently completed smoking cessation study that compared the efficacy of different intensities of psychosocial treatments coupled with 8 weeks of patch tre...

    journal_title：Drug and alcohol dependence

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0376-8716(01)00162-4

    authors： Gariti P,Alterman AI,Ehrman R,Mulvaney FD,O'Brien CP

    更新日期：2002-01-01 00:00:00

  • Patterns of use and harm reduction practices of ecstasy users in Australia.

    abstract：:Harm reduction refers to the use of strategies to prevent or reduce harmful consequences associated with illicit drug use. There is a paucity of research concerning the harm reduction practices employed by ecstasy users. This study aimed to explore the prevalence, nature and factors associated with harm reduction prac...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2005.09.009

    authors： Allott K,Redman J

    更新日期：2006-04-28 00:00:00

  • Relationship between central serotonergic neurotransmission and reduction in alcohol intake by citalopram.

    abstract：:The relationship between the effect of citalopram on alcohol intake and central serotonergic neurotransmission, as assessed by prolactin (PRL) response to fenfluramine, was investigated in 17 male heavy drinkers. A positive correlation was obtained, suggesting that the status of central serotonergic neurotransmission ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(00)00218-0

    authors： Berggren U,Eriksson M,Fahlke C,Balldin J

    更新日期：2001-08-01 00:00:00

  • Neurophysiological, psychological and behavioural correlates of rTMS treatment in alcohol dependence.

    abstract：BACKGROUND:Addiction is associated with dorso-lateral prefrontal cortex (DLPFC) dysfunction and altered brain-oscillations. High frequency repetitive transcranial magnetic stimulation (HFrTMS) over DLPFC reportedly reduces drug craving. Its effects on neuropsychological, behavioural and neurophysiological are unclear. ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2015.11.018

    authors： Del Felice A,Bellamoli E,Formaggio E,Manganotti P,Masiero S,Cuoghi G,Rimondo C,Genetti B,Sperotto M,Corso F,Brunetto G,Bricolo F,Gomma M,Serpelloni G

    更新日期：2016-01-01 00:00:00

  • Community engagement to implement evidence-based practices in the HEALing communities study.

    abstract：BACKGROUND:The implementation of evidence-based practices to reduce opioid overdose deaths within communities remains suboptimal. Community engagement can improve the uptake and sustainability of evidence-based practices. The HEALing Communities Study (HCS) aims to reduce opioid overdose deaths through the Communities ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.108326

    authors： Sprague Martinez L,Rapkin BD,Young A,Freisthler B,Glasgow L,Hunt T,Salsberry PJ,Oga EA,Bennet-Fallin A,Plouck TJ,Drainoni ML,Freeman PR,Surratt H,Gulley J,Hamilton GA,Bowman P,Roeber CA,El-Bassel N,Battaglia T

    更新日期：2020-12-01 00:00:00

  • Post-traumatic stress disorder and risk of prescription opioid use, over-use, and misuse among World Trade Center Health Registry enrollees, 2015-2016.

    abstract：BACKGROUND:Among veterans, post-traumatic stress disorder (PTSD) has been shown to be associated with the use and misuse of prescription opioids. Less is known about PTSD among the general population and PTSD resulting from non-combat related trauma. We sought to determine if PTSD following exposure to the World Trade ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107959

    authors： Takemoto E,Brackbill R,Martins S,Farfel M,Jacobson M

    更新日期：2020-05-01 00:00:00

  • A comprehensive model of predictors of suicide attempt in heavy drinkers: Results from a national 3-year longitudinal study.

    abstract：BACKGROUND:Heavy drinkers are at high risk for suicide attempt and suicide. Multiple factors, when examined in isolation, have been implicated in the risk of suicide attempt in this population. In this report, we present a comprehensive model of the 3-year risk of suicide attempt in heavy drinkers using a longitudinal ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2018.01.010

    authors： Hoertel N,Faiz H,Airagnes G,Blanco C,Pascal De Raykeer R,Franco S,Ducoutumany G,Lemogne C,Limosin F

    更新日期：2018-05-01 00:00:00

  • Exploration of the relationship between frequency of illness, attrition from alcohol treatment, neuropsychological status and field dependence.

    abstract：:One hundred thirty-nine male veterans receiving treatment for alcoholism were administered the Cornell Medical Index (CMI), neuropsychological tests comprising the Brain Age Quotient (BAQ) and the Group Embedded Figures Test (GEFT). Patients endorsing items on scale J (frequency of illness) of the CMI comprised a freq...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(83)90008-x

    authors： Calsyn DA,Roszell DK,Walker RD,O'Leary MR

    更新日期：1983-12-01 00:00:00

  • Diagnostic concordance of substance use disorders in DSM-III, DSM-IV and ICD-10.

    abstract：:Diagnostic concordance of DSM-III, DSM-IV and ICD-10 was tested in a heterogeneous unrestricted sample of 370 clinical cases drawn from a regional consortium. Agreement for abuse/harmful use, dependence, and the collapsed category of 'any diagnosis' was studied across eight drug classes. A probabilistic approach to th...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(94)90145-7

    authors： Langenbucher J,Morgenstern J,Labouvie E,Nathan PE

    更新日期：1994-12-01 00:00:00

  • Do early experiences with cannabis vary in cigarette smokers?

    abstract：INTRODUCTION:We examine whether regular cigarette smokers were more likely to be exposed to and use cannabis at an earlier age, and further, upon initiation, whether their initial experiences with cannabis varied from those reported by never/non-regular cigarette smokers. METHOD:A sample of 3797 Australian twins and s...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2012.09.002

    authors： Agrawal A,Madden PA,Martin NG,Lynskey MT

    更新日期：2013-03-01 00:00:00

  • Beliefs about steroids: user vs. non-user comparisons.

    abstract：:The differences in beliefs about the effects of anabolic steroid (AS) use between AS users and non-users provides potentially important clues to understanding AS use. Two groups of bodybuilders were used in this comparison: AS users (n = 20) and non-users (n = 27). Subjects completed a 40-item scale measuring their be...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(95)01211-7

    authors： Schwerin MJ,Corcoran KJ

    更新日期：1996-03-01 00:00:00

  • Predictors of utilization of an IVR self-monitoring program by problem drinkers with recent natural resolutions.

    abstract：BACKGROUND:As part of a randomized controlled trial, problem drinkers who recently initiated natural recovery on their own were offered access to an interactive voice response (IVR) self-monitoring (SM) system as a sobriety maintenance tool during early recovery when relapse risk is high. Because observed IVR utilizati...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2012.04.022

    authors： Simpson CA,Huang J,Roth DL,Chandler SD,Tucker JA

    更新日期：2012-11-01 00:00:00

  • Desipramine treatment of cocaine-dependent patients with depression: a placebo-controlled trial.

    abstract：OBJECTIVE:The aim of this study was to test the hypothesis that desipramine would be an effective treatment in cocaine abusers with current depressive disorders. METHOD:This was a randomized, 12-week, double-blind, 'placebo-controlled trial of outpatients (N = 111) meeting DSM-III-R criteria for cocaine dependence and...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2005.03.026

    authors： McDowell D,Nunes EV,Seracini AM,Rothenberg J,Vosburg SK,Ma GJ,Petkova E

    更新日期：2005-11-01 00:00:00

  • Understanding the trends in HIV and hepatitis C prevalence amongst injecting drug users in different settings--implications for intervention impact.

    abstract：BACKGROUND:A recent systematic review observed that HIV prevalence amongst injectors is negligible (<1%) below a threshold HCV prevalence of 30%, but thereafter increases with HCV prevalence. We explore whether a model can reproduce these trends, what determines different epidemiological profiles and how this affects i...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2011.10.032

    authors： Vickerman P,Martin NK,Hickman M

    更新日期：2012-06-01 00:00:00

  • Striatal and white matter volumes in chronic ketamine users with or without recent regular stimulant use.

    abstract：BACKGROUND:Previous studies found enlarged striatum and white matter in those with stimulants use disorders. Whether primarily ketamine users (Primarily-K) and ketamine users who co-used stimulants and other substances (K+PolyS) have abnormal brain volumes is unknown. This study aims to evaluate possible brain structur...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.108063

    authors： Liang H,Tang WK,Chu WCW,Ernst T,Chen R,Chang L

    更新日期：2020-05-25 00:00:00

  • Developmental lead exposure alters methamphetamine self-administration in the male rat: acquisition and reinstatement.

    abstract：:The rate of acquisition of drug self-administration and the return to drug seeking are important elements of the overall drug profile, and are essential factors in understanding risks associated with drug abuse. Experiment 1 examined the effects of perinatal (gestation/lactation) lead exposure on adult rates of acquis...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2007.12.003

    authors： Rocha A,Valles R,Bratton GR,Nation JR

    更新日期：2008-05-01 00:00:00

  • Predictors of quit attempts and successful quit attempts among individuals with alcohol use disorders in a nationally representative sample.

    abstract：BACKGROUND:This study sought to identify predictors of attempting to quit and of successfully quitting alcohol abuse or dependence in the general population. METHODS:Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). RESULTS:Approximately 10% of individuals with alcohol...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.05.019

    authors： Chiappetta V,García-Rodríguez O,Jin CJ,Secades-Villa R,Blanco C

    更新日期：2014-08-01 00:00:00

  • Plasma cyclic AMP in non-abstinent chronic alcoholics. Relation to clinical parameters.

    abstract：:Plasma cyclic AMP levels were determined in a group of 36 male chronic alcoholics during a period of their usual alcohol intake and compared to 29 normal controls. Significantly lower values (P less than 0.005) were found in the patient group. The possible influence of age, chronicity of drinking, family history of al...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(88)90003-8

    authors： Lykouras L,Markianos M,Moussas G

    更新日期：1988-02-01 00:00:00