Abstract:
:Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Howes JF,Villarreal JE,Harris LS,Essigmann EM,Cowan Adoi
10.1016/0376-8716(85)90068-7subject
Has Abstractpub_date
1985-02-01 00:00:00pages
373-80issue
3-4eissn
0376-8716issn
1879-0046pii
0376-8716(85)90068-7journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Methamphetamine (MA) abuse is a worldwide problem. Little is known about the co-morbidity of substance use disorders (SUD) and other psychiatric disorders of mothers who use MA prenatally. The Infant Development, Environment and Lifestyle (IDEAL) Study is a prospective, investigation of prenatal MA use and c...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2012.06.016
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Adolescents and young adults have the highest rates of opioid use, and despite shared risk-factors such as mental health and social pressures, there is little information on the relationship between education and opioid use disorder. In this study, we sought to assess differences in educational attainme...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107618
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is an important modulator of cognitive and social functioning in cocaine addiction but it is unclear whether ADHD symptoms and cocaine use display mutually aggravating interaction effects on cognition, social functioning, and depressive symptoms. Therefore, we ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.03.026
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:and Aims Injecting illicit drugs in public settings has been linked to a higher risk of a range of drug-related harms, including overdose and HIV infection. However, the factors associated with public injecting among HIV-positive individuals have not been previously explored. We investigated the links betwee...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.07.016
更新日期:2017-11-01 00:00:00
abstract::Young injection drug users are at heightened risk for acquisition of blood-borne infections because of their high rates of unsafe injection behaviors, yet there has been little research examining the circumstances surrounding injection drug users' first injection experience ('hit'). We examined the relationship betwee...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2004.08.021
更新日期:2005-03-07 00:00:00
abstract:BACKGROUND:Genetic influences on smoking cessation treatment outcome may be affected by pretreatment patient characteristics. Nicotine dependence is arguably the most salient clinical factor in smoking cessation. METHODS:In this secondary analysis of clinical trial data (N=793), we examined nicotine dependence severit...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.02.016
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatmen...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.drugalcdep.2018.08.020
更新日期:2018-12-01 00:00:00
abstract::There has been a considerable increase in the number of intravenous amphetamine misusers during the last decade, and the development of effective treatment strategies for this high-risk group has become critical. The use of substitute prescribing is one option, but reservations have been expressed as to its demonstrat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00052-0
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Alcohol protective behavioral strategies (PBS) have been proposed as mechanisms of change underlying interventions for reducing alcohol use and alcohol-related problems. Few studies have examined PBS use among non-college student populations and no study has examined PBS use among adult injured patients. The...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.drugalcdep.2019.06.037
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Methamphetamine use, with and without opioids, has increased substantially, but little is known about the sociodemographic characteristics, substance use patterns, or health profiles of individuals who use methamphetamine. To design effective public health interventions, health care professionals and policym...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108162
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:A number of studies have researched the association between monoamine oxidase gene (MAO) polymorphisms and smoking behavior, but the conclusion is quite inconsistent. A meta-analysis was conducted to assess the association of MAO-A C1460T, MAO-A VNTR and MAO-B G644A polymorphisms with smoking behavior. METH...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,meta分析
doi:10.1016/j.drugalcdep.2015.05.024
更新日期:2015-08-01 00:00:00
abstract::A confidential and anonymous survey of 3623 adolescents was carried out in eight schools (six state comprehensive and two independent) in Newcastle upon Tyne. The survey enquired about cigarette use, alcohol consumption and illicit drug use together with key demographic variables. The results showed that 21% were curr...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(94)01073-t
更新日期:1995-03-01 00:00:00
abstract::Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Previously published results have established that chronic cocaine administration (30-45 mg/kg per day, 10-14 days) resulted in an upregulation of TH gene expression in dopaminergic pathways of rats. The present studies tested the eff...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(00)00119-8
更新日期:2000-12-22 00:00:00
abstract:BACKGROUND:Approximately 700,000 Social Security beneficiaries in the U.S. with psychiatric disabilities have been assigned a representative payee to manage their funds but it is unclear how those judged to need a payee differ from others and whether payee assignment improves clinical outcomes, especially substance abu...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.05.026
更新日期:2007-01-12 00:00:00
abstract::The purpose of the present investigation was to examine the development of tolerance to the effects of morphine and other mu opioids in rats responding under a fixed-consecutive-number (FCN) schedule of food presentation. To this end, five rats were trained under an FCN schedule and subsequently tested with a variety ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00039-2
更新日期:1997-06-06 00:00:00
abstract:BACKGROUND:The nucleus accumbens (NAc) is a ventral striatal structure underlying reward, reinforcement, and motivation, with extensive anatomic and functional connections to a wide range of affective processing structures (medial prefrontal cortex (mPFC), amygdala, and insula). Characterizing how acute alcohol intake ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107811
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:A recent systematic review observed that HIV prevalence amongst injectors is negligible (<1%) below a threshold HCV prevalence of 30%, but thereafter increases with HCV prevalence. We explore whether a model can reproduce these trends, what determines different epidemiological profiles and how this affects i...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.10.032
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Heroin-related cues can trigger craving and relapse in addicts or heroin seeking in rats. In the present study we investigated whether environmental enrichment (EE) implemented after heroin exposure can reduce cue-induced reinstatement of heroin seeking and expression of heroin conditioned place preference. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.04.016
更新日期:2016-06-01 00:00:00
abstract::Impulsivity appears to play an important role in suicidal behaviors and drug abuse, which are two psychiatric problems that may interact with one another. Interpretation of the literature on impulsivity in these behaviors may be complicated by the variety of measurement techniques for the assessment of impulsivity. Th...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2004.08.010
更新日期:2004-12-07 00:00:00
abstract::Harm reduction refers to the use of strategies to prevent or reduce harmful consequences associated with illicit drug use. There is a paucity of research concerning the harm reduction practices employed by ecstasy users. This study aimed to explore the prevalence, nature and factors associated with harm reduction prac...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2005.09.009
更新日期:2006-04-28 00:00:00
abstract::Sequence of drug use was examined in a secondary analysis of two samples of serious drug users: one of 152 men and one of 133 women. The proportions of drug users following specified patterns of drug use onset were compared to proportions obtained in previous research in samples of high school youth, and serious drug ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00032-x
更新日期:1997-05-02 00:00:00
abstract:BACKGROUND:State prescription monitoring programs (PMPs) purport to address the prescription opioid epidemic, but have evidenced limited effect on reducing opioid-related mortality. METHODS:We systematically reviewed publicly available, PMP web-based materials from December, 2012 to October, 2013, to assess the degree...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.05.009
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The leading cause of injury death among adults in Connecticut (CT), USA is drug poisonings. We analyzed the epidemiology and geographic distribution of opioid-involved accidental drug-involved intoxication deaths ("overdoses") in CT over an 11-year period. METHODS:We reviewed data from 1997 to 2007 on all a...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.11.007
更新日期:2011-06-01 00:00:00
abstract::Serum magnesium levels may not accurately reflect overall magnesium homeostasis. To clarify the relationship between serum and intracellular magnesium concentrations in chronic alcoholism, we determined intralymphocytic magnesium levels and serum magnesium, sodium and potassium concentrations in ten chronic alcoholic ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00037-9
更新日期:1997-06-06 00:00:00
abstract:INTRODUCTION:Drug dealing among drug users has been associated with elevated risk-taking and negative health outcomes. However, little is known about the cessation of drug dealing among this population. METHODS:We assessed time to cessation of drug dealing using Cox regression. We also used generalized estimating equa...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.05.008
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Brief motivational intervention (BMI) is one of the few effective strategies targeting alcohol consumption, but has not been tested in young men in the community. We evaluated the efficacy of BMI in reducing alcohol use and related problems among binge drinkers and in maintaining low-risk drinking among non-...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2010.07.009
更新日期:2011-01-01 00:00:00
abstract::Recently, incarcerated individuals are at increased risk of opioid overdose. Methadone maintenance treatment (MMT) is an effective way to address opioid use disorder and prevent overdose; however, few jails and prisons in the United States initiate or continue people who are incarcerated on MMT. In the current study, ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2017.11.023
更新日期:2018-03-01 00:00:00
abstract::Offenders incarcerated for violent and property crimes were compared with respect to their alcohol and drug use, both chronic and immediately before their crime. There were only slight differences between the groups. The proportions of violent offenders who drank before the crime were greater than the proportion of pr...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(87)90018-4
更新日期:1987-07-01 00:00:00
abstract::The prevalence of cannabis use is rising among adolescents, many of whom perceive little risk from cannabis. However, clinicians who treat adolescent substance users hear frequent reports of serious cannabis-use disorders and problems. This study asked whether cannabis produced dependence and withdrawal among such pat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00003-9
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Research indicates that early tobacco initiation increases risk for dependence, but despite this, early initiation is associated with slower transitions to escalated tobacco use. In contrast to these findings, other studies suggest that rapid escalated tobacco use is associated with increased dependence outc...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.04.027
更新日期:2019-09-01 00:00:00