Xorphanol.

Abstract:

:Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.

journal_name

Drug Alcohol Depend

authors

Howes JF,Villarreal JE,Harris LS,Essigmann EM,Cowan A

doi

10.1016/0376-8716(85)90068-7

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

373-80

issue

3-4

eissn

0376-8716

issn

1879-0046

pii

0376-8716(85)90068-7

journal_volume

14

pub_type

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