Abstract:
:There has been a considerable increase in the number of intravenous amphetamine misusers during the last decade, and the development of effective treatment strategies for this high-risk group has become critical. The use of substitute prescribing is one option, but reservations have been expressed as to its demonstrated effectiveness in reducing injecting practice and associated risks. This study compares the effect of substitute prescribing on the injecting practices of two groups of intravenous drug misusers: 120 primary opiate misusers, prescribed oral methadone; and 60 primary amphetamine misusers, prescribed dexamphetamine elixir. The levels of intravenous drug misuse at time of discharge for the two groups was similar, with 67% of the opiate misusers and 70% of the amphetamine misusers having stopped injecting.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Charnaud B,Griffiths Vdoi
10.1016/s0376-8716(98)00052-0subject
Has Abstractpub_date
1998-09-01 00:00:00pages
79-84issue
1eissn
0376-8716issn
1879-0046pii
S0376-8716(98)00052-0journal_volume
52pub_type
杂志文章abstract::An elevated rate of alcohol problems is believed to exist in the gay and lesbian community. However, prevalence estimates suggesting this have generally been based on convenience samples which have over-represented bar patrons and clinical sources. Recent epidemiological studies examining risk factors for AIDS have ga...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(93)90112-4
更新日期:1993-10-01 00:00:00
abstract::The purpose of this study was to clarify the extent of neuropsychological impairment previously found among amphetamine users (McKetin and Mattick, 1997) by comparing them with a non-drug-using control group. Amphetamine users who were classified as low dependence (n = 15) or high dependence (n = 11) according to the ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00022-2
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:The effects of parent-based interventions on adolescent alcohol use are unclear, including what factors moderate intervention effects. This study examines the effects of parent-based interventions on adolescent alcohol use and whether the treatment effects vary by participants' characteristics and interventi...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.drugalcdep.2018.05.031
更新日期:2018-10-01 00:00:00
abstract::A series of beta-carbolines were prepared and their affinities for imidazoline (I(1) and I(2)) sites evaluated. Selected compounds were also examined at alpha(2)-adrenoceptors. Some of the beta-carbolines were found to bind with high affinity to I(2)-sites and this affinity was dependent on both the planarity of the m...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(01)00123-5
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Methadone maintenance therapy (MMT) is an efficacious form of medication assisted treatment for opioid use disorder (OUD), yet many individuals on MMT relapse. Chronic pain and deficits in positive affective response to natural rewards may result in dysphoria that fuels opioid craving and promotes relapse. A...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.07.007
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Demand for treatments for severe opioid use disorder is increasing worldwide. The current pharmacotherapy is mainly focused on opioid and adrenergic receptors. The N-methyl-d-aspartate receptor (NMDAR) is among other receptors that can also be targeted to treat the disease. Findings from randomized controlle...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107845
更新日期:2020-03-01 00:00:00
abstract::Heavy alcohol consumption is associated with an increased risk of heart failure. We sought to investigate whether levels of NT-proBNP differ by alcohol consumption profiles, both current drinking as well as cumulative exposure to drinking over several decades in a general population sample. METHODS:Data on 2054 parti...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108048
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Methadone maintenance treatment (MMT) is effective in decreasing opioid use or facilitating abstinence. Previous studies using small opioid use disorder samples suggest that cognitive impairments including impulsivity and executive functions may partially improve on MMT, but a range of deficits may persist. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108483
更新日期:2021-02-01 00:00:00
abstract::Injection drug users (IDUs) who have recently initiated an injecting career have high risk behaviors for HIV infection. The average age of an IDUs first injection is typically reported as 19-20 years, and some literature has reported 'maturing out' of drug use typically around 40 years old. The purpose of this study w...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00142-2
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Men who have sex with men (MSM) who use crystal methamphetamine (CM) are at increased risk for HIV infection. Post-exposure prophylaxis (PEP) is a useful HIV prevention strategy if individuals are able to identify high-risk exposures and seek timely care, however to date there has been limited data on the us...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.11.010
更新日期:2015-01-01 00:00:00
abstract::High or inelastic demand for drugs is central to many laboratory and theoretical models of drug abuse, but it has not been widely measured with human substance abusers. The authors used a simulated cigarette purchase task to generate a demand curve measure of nicotine reinforcement in a sample of 138 adolescent smoker...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.08.004
更新日期:2011-01-15 00:00:00
abstract:BACKGROUND:Outcome expectancy is a central construct in models of addiction and relapse. Much expectancy research has been conducted in the context of alcohol; however, less is known about the structure of expectancies for marijuana and their associations with marijuana use outcomes. METHODS:The data are taken from wa...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.04.024
更新日期:2012-11-01 00:00:00
abstract::Olfactory evoked potentials (OEP) were elicited by odorous and nonodorous stimuli in 50 adult subjects: 26 subjects with histories of either cocaine (n = 19) or alcohol (n = 7) dependence, 10 with histories of nicotine but no other drug dependence, 2 with clinical anosmia of peripheral origin, and 12 subjects without ...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章
doi:10.1016/0376-8716(96)01258-6
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Previous research has demonstrated how negative affect (i.e., depression, anxiety, stress) is often a correlate of and precursor to nicotine dependence. Although recent evidence shows a gradual decline in tobacco use in the United States, subgroups that report higher levels of negative affect may continue to...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107883
更新日期:2020-04-01 00:00:00
abstract::Ethanol stimulates the spontaneous transmitter release from motor nerve endings, as shown by the increase of miniature end plate potential (m.e.p.p.) frequency at the neuro-muscular junction. The stimulation of acetylcholine spontaneous quantal release by ethanol is greater in regenerating than in mature nerve endings...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(86)90044-x
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:It has been proposed that relapse vulnerability in previously dependent individuals results from augmentation of drug-induced reinforcement due to repeated associations between the interoceptive properties of the drug and reduction of acute withdrawal distress. METHODS:To test this hypothesis, male Sprague-...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.01.007
更新日期:2014-05-01 00:00:00
abstract::Premature termination of treatment by the client has been a pervasive problem in the alcohol treatment field. This drop-out problem is compounded in conjoint therapy for alcoholic couples since most clients typically do not view the drinking problem from a systemic, interactional perspective. Within a short-term commu...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(83)90023-6
更新日期:1983-06-01 00:00:00
abstract::The effects of subchronic nicotine treatment on the development of tolerance and on two nicotinic ligand binding sites were investigated. After subcutaneous injection of nicotine (0.45 mg nicotine base/kg) or saline twice a day for 14 days the body weight of rats was significantly lower than that of control animals. A...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(86)90034-7
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Social impairments are important features of a substance use disorder diagnosis; and recent models suggest early impairments in socio-cognitive and -affective processes may predict future use. However, no systematic reviews are available on this topic. METHODS:We conducted a systematic review and meta-analy...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2020.108479
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:Determine if a brief intervention (BI) reduces the negative consequences of drug use/misuse among adult emergency department (ED) patients, and identify patients more likely to benefit from the BI. METHODS:This randomized, controlled trial enrolled 1026 18-64 year-old ED patients whose drug misuse indicated...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2015.10.007
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Alcohol use among individuals with opioid use disorder (OUD) can be dangerous, and understanding factors contributing to alcohol use in this population is important. The current study examined alcohol use among individuals with prescription OUD based on distress tolerance. It was hypothesized that individual...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.05.016
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:This paper examines the relative importance of three religion variables (religious preference, religiosity, and alcohol proscription) and eight demographic variables (gender, ethnicity, education, income, marital status, age, region, and employment status) as statistical predictors of drinking versus abstenti...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.07.013
更新日期:2007-03-16 00:00:00
abstract:BACKGROUND:Examining whether smoking is a risk factor for posttraumatic stress disorder (PTSD) symptoms among rescue workers affected by a disaster. METHODS:Ambulance personnel (N=66) participated in surveys 2-3 weeks (T1) and 18 months after a fireworks disaster (T2). Hierarchical multiple regression analyses were co...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.11.001
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Kratom preparations have raised concerns of public health and safety in the US. Investigation into the demographics, perceived beneficial and detrimental effects of Kratom as well as common doses and purposes of its use are important to properly evaluate its potential health impact. METHODS:An anonymous cro...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.03.007
更新日期:2017-07-01 00:00:00
abstract:AIM:To examine how buprenorphine is currently being used across Italy, and to identify simultaneously best practice protocols to guide physicians in optimising the safety and efficacy of this treatment option. DESIGN:Retrospective, observational, multi-centre study. PARTICIPANTS:A total of 979 opioid-dependent patien...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2007.10.017
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that opioid overdose and HIV infection are burgeoning intertwined epidemics among people who inject drugs (PWID) in Central Asia. To date, however, research on overdose and its associations with HIV risks among PWID in Central Asia remains virtually absent. This paper aims to p...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2013.07.017
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Despite the high rates of comorbidity of post-traumatic stress disorder (PTSD) and alcohol dependence (AD) in clinical and epidemiological samples, little is known about the prevalence, clinical presentation, course, risk factors and patterns of treatment-seeking of co-occurring PTSD-AD among the general pop...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.04.016
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Little is known about risk factors for repeated opioid overdose and fatal opioid overdose in the first year following nonfatal opioid overdose. METHODS:We identified a national retrospective longitudinal cohort of patients aged 18-64 years in the Medicaid program who received a clinical diagnosis of nonfata...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.06.004
更新日期:2018-09-01 00:00:00
abstract::In a sample survey of 712 Iranian male adolescents, aged 14-18, it was found that drugs users differed in only some of theirs beliefs about drug substances and their use from their non-drug-using contemporaries; and that both sub-samples had, in their agreement about the drug problem in post-revolutionary Iran, been e...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(82)90001-1
更新日期:1982-10-01 00:00:00
abstract::The aim of this study was to determine if substitution of daily methadone with second daily levo-alpha-acetylmethadol (LAAM) would convert non-holders on methadone into holders on LAAM, and to compare plasma concentration-time profiles of (R)-methadone with LAAM and its two metabolites. Sixteen stable methadone mainte...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2004.04.004
更新日期:2004-10-05 00:00:00