Abstract：
BACKGROUND:Outcome expectancy is a central construct in models of addiction and relapse. Much expectancy research has been conducted in the context of alcohol; however, less is known about the structure of expectancies for marijuana and their associations with marijuana use outcomes. METHODS:The data are taken from waves 3 and 4 of a longitudinal high-risk study of parents and adolescent offspring. Of those families who were retained at wave 3, 225 were high-risk and 205 were matched controls (low-risk). In the present study, we examine the factorial structure of marijuana expectancies (wave 3) in the offspring (using an instrument adapted from the alcohol literature) and test whether expectancies mediate the associations of familial risk for substance use, lifetime marijuana use in adolescence (wave 3) and current use in young adulthood (wave 4; reported approximately 5 years later). RESULTS:We quantified four marijuana expectancy factors similar to those identified in previous studies when the offspring were adolescents (Mn age=15.2) and results of our mediation models suggest that negative marijuana expectancies (but not positive expectancies) together with lifetime adolescent marijuana use completely mediated the association between familial risk and current use of marijuana during young adulthood (Mn age=20.2). CONCLUSION:Familial risk for current marijuana use in young adulthood appears to be transmitted through two orthogonal, prospective pathways. One pathway involves marijuana use during adolescence, and the second pathway involves reduced expectancies that using marijuana will result in cognitive and behavioral impairments.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Kristjansson SD,Agrawal A,Lynskey MT,Chassin LAdoi
10.1016/j.drugalcdep.2012.04.024subject
Has Abstractpub_date
2012-11-01 00:00:00pages
102-10issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(12)00150-0journal_volume
126pub_type
杂志文章abstract：BACKGROUND:Cocaine addiction continues to be a significant healthcare issue, yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States. METHODS:This 12-week, prospective, double-blind, randomized, placebo-controlled study examined the effectiveness of quetiapine (Sero...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2014.12.037
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Heavy alcohol consumption may accelerate the progression of hepatitis C-related liver disease and/or limit efforts at antiviral treatment in opioid-dependent patients receiving heroin-assisted treatment (HAT). Our study aims to assess alcohol intake among HAT patients by self-reports compared to direct ethan...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.020
更新日期：2011-05-01 00:00:00
abstract：:Using a 'snowballing' technique, prospective data have been collected from 135 regular drug using individuals in two Scottish towns, Edinburgh, and Ayr. Data from the first wave would suggest that poly drug use is common, with a major reliance on licit, prescribed substances. Amongst both intravenous and non-intraveno...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90013-6
更新日期：1989-04-01 00:00:00
abstract：:Subjective and electroencephalographic reactions to cocaine cues were evaluated in 33 cocaine-dependent out-patients and 17 non-cocaine-dependent controls. Subjective, EEG, and autonomic reactions to three 5-min videos (cocaine-associated, erotic, neutral) were evaluated twice with an interpolated 1-week interval. Bet...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0376-8716(95)01165-3
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:The Alcohol Use Disorders Identification Test (AUDIT) is an international screening instrument extensively employed in adult target groups. However, there is scarce information on screening with the AUDIT in adolescent populations. The purpose of this study was to determine the cut-off point for hazardous, h...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2009.01.017
更新日期：2009-08-01 00:00:00
abstract：INTRODUCTION:Exposure to child maltreatment is associated with elevated risk for behavioral disorders in adulthood. One explanation for this life-course association is that child maltreatment increases vulnerability to the effects of subsequent stressors; however, the extent to which maltreatment increases sensitivity ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.09.013
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Abuse of psychostimulants, including methamphetamine (MA), has been linked to heightened impulsivity. While previous research has demonstrated differences in impulsivity between MA users and non-substance users, less is known about variability in impulsivity within MA users and whether the severity of MA use...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.01.034
更新日期：2018-06-01 00:00:00
abstract：:In a sample survey of 712 Iranian male adolescents, aged 14-18, it was found that drugs users differed in only some of theirs beliefs about drug substances and their use from their non-drug-using contemporaries; and that both sub-samples had, in their agreement about the drug problem in post-revolutionary Iran, been e...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(82)90001-1
更新日期：1982-10-01 00:00:00
abstract：:The main question addressed by this paper is whether DSM-IV substance dependence diagnoses obtained from two different instruments (the semi-structured WHO Schedules for Clinical Assessment in Neuropsychiatry, SCAN and the highly structured WHO Composite International Diagnostic Interview--Substance Abuse Module, SAM)...
journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0376-8716(96)01249-5
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Injecting drug use is associated with a range of harms, however cessation of injecting is rare. There is a lack of evidence on factors associated with cessation, notably those related to health services other than drug treatment. We examined the incidence and identified longitudinal correlates of first episo...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.06.037
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Known most commonly in the U.S. as "hookah," waterpipe tobacco smoking appears to be growing among college students. Despite beliefs that waterpipe use is safer than cigarette smoking, research to date (albeit limited) has found health risks of waterpipe smoking are similar to those associated with cigarette...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2011.01.018
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:We investigated the prevalence of HIV-positive patients discussing alcohol use with their HIV primary care providers and factors associated with these discussions. METHODS:We recruited 1225 adult participants from 10 HIV care clinics in three large US cities from May 2004 to 2005. Multivariate logistic regr...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.12.006
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Recent years have seen a rise in the diversity and use of synthetic cannabinoids. The present study evaluated the behavioral effects of the third-generation indazole-3-carboxamide-type synthetic cannabinoid, AB-FUBINACA. METHODS:Adult male and female C57BL/6J mice were treated with AB-FUBINACA (0-3 mg/kg, i...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108179
更新日期：2020-09-01 00:00:00
abstract：:The leading cause of death among heroin users is drug overdose. The present study examined the relationship between history of self-reported drug overdoses and social network characteristics among cocaine and opiate users. Data were from cross-sectional surveys administered from March 2001 through February 2003 as par...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2003.09.005
更新日期：2004-01-07 00:00:00
abstract：BACKGROUND:Adolescence and early-adulthood are vulnerable developmental periods during which binge drinking can have long-lasting effects on brain function. However, little is known about the effects of binge drinking on the pyramidal cells of the prelimbic cortex (PrL) during early and protracted withdrawal periods. ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108309
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:The ability to predict potential for relapse to substance use following treatment could be very useful in targeting aftercare strategies. Recently, a number of investigators have focused on using neural activity measured by fMRI to predict relapse propensity. The purpose of the present study was to use fMRI ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2013.04.008
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking. METHODS:Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamp...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.03.030
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:While it has been demonstrated that smoking cigarettes in adolescence increases the likelihood of progressing to marijuana use, few studies have considered the reverse scenario in which early use of cannabis leads to greater tobacco smoking. METHODS:Participants (n=5963), who had never smoked cigarettes dai...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2006.11.005
更新日期：2007-05-11 00:00:00
abstract：BACKGROUND:We examined the effects of baseline drug use and dependence on alcohol use outcomes following brief motivational intervention for at-risk drinking (BMI-ETOH). METHODS:HLM models were developed to test the interaction of drug use and dependence with BMI-ETOH for alcohol use among Hispanic (n=539), Caucasian ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2012.04.009
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Cannabis is the most widely used illicit drug in developed countries, and has a significant impact on mental and physical health in the general population. However, the validity of common diagnostic schemes and their applicability to cannabis abuse and dependence is poorly understood. This paper describes a ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00223-5
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Adolescence is a stage of development with increased risk of drug use. Individual personality traits are among those factors that influence the onset of substance use in adolescence and its psychiatric comorbidity. Little research has been done on the comorbidity between substance abuse risk and Asperger syn...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.07.022
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:This study used a case-control female sample to test psychiatric mediators and genetic moderators of the effect of sexual abuse on later alcohol dependence. The study also tested differences between alcohol dependent women with or without a history of sexual abuse on variables that might affect tre...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.024
更新日期：2011-06-01 00:00:00
abstract：:The aim of this study is to shed light upon an observed association between the use of marijuana and hallucinogens (e.g. LSD), with a specific focus on the idea that two separate mechanisms might link marijuana use to hallucinogen use: (1) greater hallucinogen exposure opportunity for marijuana users versus nonusers; ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(01)00191-0
更新日期：2002-04-01 00:00:00
abstract：:A group of adolescent drug "experimenters" as defined by the frequency of use (N = 496) were compared to non-users (N = 2417) and to "regular" users (N = 125) on a number of variables. These covered the patterns of use, attitudes to drug use, exposure to drugs and to drug use, and other behavioural correlates. Experim...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(90)90127-z
更新日期：1990-10-01 00:00:00
abstract：INTRODUCTION:Buprenorphine/naloxone treatment is a highly effective treatment for opioid use disorder decreasing illicit opioid use and both all-cause and opioid-involved overdose mortality. The purpose of this study was to investigate the relationships between buprenorphine/naloxone prescribing and high-dose opioid an...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107606
更新日期：2019-12-01 00:00:00
abstract：:Endogenous opioids acting at mu-opioid receptors mediate many biological functions. Pharmacological intervention at these receptors has greatly aided in the treatment of acute and chronic pain, in addition to other uses. However, the development of tolerance and dependence has made it difficult to adequately prescribe...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2009.12.016
更新日期：2010-05-01 00:00:00
abstract：:Despite the fact that tobacco and marihuana are often used together, relatively little is known about the effects of this combination. In order to investigate the effects of the principal psychoactive component in tobacco smoke, nicotine, on marihuana-induced intoxication, we conducted a double blind, cross-over exper...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2005.01.008
更新日期：2005-08-01 00:00:00
abstract：:High doses of stimulants of abuse, such as methamphetamine and cocaine, cause significant increases in the content of neurotension- and dynorphin-like immunoreactivity in the striatum and nucleus accumbens (approximately 200-600% of control) in the rat. These changes in neuropeptide content are caused by stimulation o...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(94)01065-s
更新日期：1995-02-01 00:00:00
abstract：:The literature on opium addiction in Asia reveals widely different sex ratios. Analysis of these reports indicates that community surveys provide the most reliable and valid ratios. Surveys in psychiatric hospitals appear to overreport women, while case registers and surveys in addiction treatment facilities, vends an...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(80)90451-2
更新日期：1980-09-01 00:00:00
abstract：:Self-reports of drug use frequency are central to treatment outcome evaluations, estimates of the prevalence of heavy use, estimates of treatment need, and other questions with direct relevance to drug policies. Nevertheless, surprisingly little is known about the validity of these self-reports. This study examines th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(99)00048-4
更新日期：2000-01-01 00:00:00
