Abstract:
BACKGROUND:Adolescence and early-adulthood are vulnerable developmental periods during which binge drinking can have long-lasting effects on brain function. However, little is known about the effects of binge drinking on the pyramidal cells of the prelimbic cortex (PrL) during early and protracted withdrawal periods. METHODS:In the present study, we performed whole-cell patch clamp recordings and dendritic spine staining to examine the intrinsic excitability, spontaneous excitatory post-synaptic currents (sEPSCs), and spine morphology of pyramidal cells in the PrL from rats exposed to chronic intermittent ethanol (CIE) during adolescence or early-adulthood. RESULTS:Compared to chronic intermittent water (CIW)-treated controls, the excitability of PrL-L5 pyramidal neurons was significantly increased 21 days after adolescent CIE but decreased 21 days after early-adult CIE. No changes of excitability in PrL Layer (L) 5 were detected 2 days after either adolescent or early-adulthood CIE. Interestingly, decreases in sEPSC amplitude and increases in thin spines ratio were detected 2 days after adolescent CIE. Furthermore, decreased frequency and amplitude of sEPSCs, accompanied by a decrease in the density of total spines and non-thin spines were observed 21 days after adolescent CIE. In contrast, increased frequency and amplitude of sEPSCs, accompanied by increased densities of total spines and non-thin spines were found 21 days after early adult CIE. CONCLUSION:CIE produced prolonged neuronal and synaptic alterations in PrL-L5, and the developmental stage, i.e., adolescence vs. early-adulthood when subjects receive CIE, is a key factor in determining the direction of these changes.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Galaj E,Guo C,Huang D,Ranaldi R,Ma YYdoi
10.1016/j.drugalcdep.2020.108309subject
Has Abstractpub_date
2020-11-01 00:00:00pages
108309eissn
0376-8716issn
1879-0046pii
S0376-8716(20)30474-9journal_volume
216pub_type
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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pub_type: 杂志文章,多中心研究
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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