Abstract:
BACKGROUND:Recent years have seen a rise in the diversity and use of synthetic cannabinoids. The present study evaluated the behavioral effects of the third-generation indazole-3-carboxamide-type synthetic cannabinoid, AB-FUBINACA. METHODS:Adult male and female C57BL/6J mice were treated with AB-FUBINACA (0-3 mg/kg, i.p.) and tested repeatedly in the tetrad battery measuring catalepsy, antinociception, hypothermia, and locomotor activity. Mice treated with AB-FUBINACA (≥2 mg/kg, i.p.) displayed classic cannabinoid effects in the tetrad that were blocked by the CB1 receptor selective antagonist rimonabant. To address tolerance and withdrawal effects, a second group of mice was injected with AB-FUBINACA (3 mg/kg, s.c.) or vehicle consisting of 5% ethanol, 5% Kolliphor EL, and 90 % saline every 12 h and tested daily in modified tetrad over the course of 5 days. On the 6th day, withdrawal was precipitated using rimonabant (3 mg/kg, s.c.), and somatic signs of withdrawal (i.e., head twitches and paw tremors) were quantified. RESULTS:Although mice did not develop tolerance to AB-FUBINACA or cross-tolerance to Δ9-tetrahydrocannabinol (THC; 50 mg/kg, i.p.), somatic precipitated withdrawal signs were observed. Repeated tetrad testing up to 48 h post injection indicated that AB-FUBINACA effects are relatively short-lived, as compared with THC. Brain levels of AB-FUBINACA, as quantified by UHPLC-MS/MS, were undetectable 4 h post injection. CONCLUSIONS:These data indicate that the cannabinoid effects of AB-FUBINACA are relatively short-lived, yet sufficient to induce dependence in mice.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Trexler KR,Vanegas SO,Poklis JL,Kinsey SGdoi
10.1016/j.drugalcdep.2020.108179subject
Has Abstractpub_date
2020-09-01 00:00:00pages
108179eissn
0376-8716issn
1879-0046pii
S0376-8716(20)30344-6journal_volume
214pub_type
杂志文章abstract:BACKGROUND:The use, misuse and co-use of alcohol, cannabis, tobacco, and other licit and illicit controlled substances has increased in past decades leading to higher rates of morbidity, overdose, and mortality in women of reproductive age. Co-use compounds the adverse health effects of substance use compared to single...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107729
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Many Pacific Island countries are in social and epidemiological transition, but there are little population data about drug and alcohol usage among adolescents in this region. METHODS:Random samples of school students aged 11-17 years completed surveys in three populations: Pohnpei State in the Federated St...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.08.030
更新日期:2007-04-17 00:00:00
abstract:BACKGROUND:People who inject drugs (PWID) have a high prevalence of mental health problems (e.g., depression) which compromise the effects of HIV prevention. We investigated the prevalence of depression and associated factors among PWID in Dazhou, China. METHODS:Anonymous face-to-face interviews were administered to e...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.03.028
更新日期:2015-06-01 00:00:00
abstract::Inhalant abuse has existed for a considerable period of time and it is currently one of the most prevalent drug abuse problems in the world. One repercussion from using these compounds is that abuse may result in lethality. In an attempt to better understand the deaths associated with inhalant abuse, the authors surve...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00139-2
更新日期:1999-02-01 00:00:00
abstract::The oral administration of single doses (0.5-6.0 g/kg) of ethanol to rats, shortly before injecting them with a large dose (3.0 mg base/kg) of epinephrine subcutaneously, significantly reduced the severity of the myocardial damage produced by the epinephrine. The larger the dose of ethanol, the greater was the protect...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(77)90041-2
更新日期:1977-09-01 00:00:00
abstract::It is argued that studying the drinking patterns of adolescents can add much to our understanding of alcohol use. The present paper hypothesises that heavy drinkers will be experiencing more stress than light, moderate or non-drinkers and that consequently, they will perceive themselves as doing worse in school and wi...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(85)90113-9
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:While a majority of cigarette smokers who use electronic cigarettes (e-cigarettes) choose to continue using cigarettes, completely switching to e-cigarettes is necessary to reduce tobacco-related harm. Whether specific subjective responses to e-cigarettes are associated with extent of smoking reduction and c...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107999
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:This study examined factors associated with marijuana use initiation among never users, prior-to-past year user who return to use, and users who continue use over a 12-month follow-up period. METHODS:Two waves (W1 and W2) of the Population Assessment of Tobacco and Health (PATH) Study provided data (N=26,20...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.10.006
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Few studies of the natural history of DSM-IV inhalant substance use disorders (I-SUDs) have been conducted. This investigation examined the prevalence, timing, and predictors of transitions from inhalant use to formal I-SUDs among inhalant users within a nationally representative sample. METHODS:Participant...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2008.10.017
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The misuse of benzodiazepines (BZs) among adolescents is an important issue within the fields of mental health, medicine, and public health. Though there is an increasing amount of research on prescription medication misuse, a relatively small number of studies focus on adolescent BZ misuse. The goal of this...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.01.026
更新日期:2014-04-01 00:00:00
abstract::Administrative data provide a rich resource for improving our understanding of individuals with substance use disorders. The validation of administrative proxies for moderate or high risk alcohol or drug (AOD) use could enhance the ability to carry out rigorous observational research (for example, for use in the const...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.03.013
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Methadone maintenance treatment (MMT) is effective in decreasing opioid use or facilitating abstinence. Previous studies using small opioid use disorder samples suggest that cognitive impairments including impulsivity and executive functions may partially improve on MMT, but a range of deficits may persist. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108483
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Known most commonly in the U.S. as "hookah," waterpipe tobacco smoking appears to be growing among college students. Despite beliefs that waterpipe use is safer than cigarette smoking, research to date (albeit limited) has found health risks of waterpipe smoking are similar to those associated with cigarette...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2011.01.018
更新日期:2011-05-01 00:00:00
abstract::To study the relationship between cocaine abstinence symptoms, personality, and aggression, we used the Point Subtraction Aggression Paradigm (PSAP) to measure aggression in 18 subjects admitted for the treatment of cocaine dependence. Eight subjects met criteria for antisocial personality disorder (ASPD). There was a...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(96)01335-x
更新日期:1997-03-14 00:00:00
abstract::Fifty of sixty original study subjects were assessed via two questionnaires and urinalysis tests between six months and one year following completion of the experimental program. Results indicate a high rate of retention in methadone/methadyl acetate treatment, and point to the need for positive social context, satisf...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(80)90195-7
更新日期:1980-11-01 00:00:00
abstract::Investigators on fetal alcohol syndrome (FAS) both clinical and experimental, have generally concentrated attention on chronic alcoholism. In an attempt to elucidate the effects of binge drinking on pre- and postnatal development, single doses of 0.01, 0.02 and 0.03 ml/g body weight of alcohol solutions (25% v/v of et...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(84)90045-0
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Technology-based applications represent a promising method for providing efficacious, widely available interventions to substance abuse treatment patients. However, limited access to communication technology (i.e., mobile phones, computers, internet, and e-mail) could significantly impact the feasibility of ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.10.003
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Mental health problems have been identified among soldiers serving in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF), but little is known about the prevalence and management of alcohol misuse in OEF/OIF veterans seen in the Veterans Administration health care system (VA). METHODS:We identified 12,0...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2009.12.025
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Marijuana and tobacco are the substances used most commonly by adolescents and co-occurring use is common. Use of one substance may potentiate the addictive properties of the other. The current study examined the severity of nicotine addiction among teen smokers as a function of co-occurring marijuana use. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.05.015
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:This study examined whether starting buprenorphine treatment prior to prison and after release from prison would be associated with better drug treatment outcomes and whether males and females responded differently to the combination of in-prison treatment and post-release service setting. METHODS:Study des...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2016.11.037
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The Russian Federation is experiencing a very high rate of HIV infection among people who inject drugs (PWID). However, few studies have explored characteristics of people with co-occurring opioid use disorders and HIV, including psychiatric symptom presentations and how these symptoms might relate to qualit...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2016.12.007
更新日期:2017-03-01 00:00:00
abstract::Our objective was to examine the cost of long-term residential (LTR) and outpatient drug-free (ODF) treatments for cocaine-dependent patients participating in the Drug Abuse Treatment Outcome Studies (DATOS), calculate the tangible cost of crime to society, and determine treatment benefits. Subjects were 502 cocaine-d...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(99)00083-6
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2017.05.001
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Cannabidiol, a therapeutic with potential serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A receptor agonist activity, is the second most prevalent cannabinoid in Cannabis after Δ(9)-THC. The extent to which cannabidiol modifies the effects of Δ(9)-THC has not been firmly established, especially with respect to a...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.05.016
更新日期:2016-08-01 00:00:00
abstract::The prevalence of cannabis use is rising among adolescents, many of whom perceive little risk from cannabis. However, clinicians who treat adolescent substance users hear frequent reports of serious cannabis-use disorders and problems. This study asked whether cannabis produced dependence and withdrawal among such pat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00003-9
更新日期:1998-03-01 00:00:00
abstract::The present experiment investigated contextual renewal of cocaine seeking and potential methods of attenuating this renewal. Rats were first trained in one context to self-administer cocaine when a discriminative stimulus (tone) was presented. Then, the ABA Group was placed in a second context and responses in tone no...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.03.006
更新日期:2007-10-08 00:00:00
abstract::Using a national population sample of adults who had ever consumed at least 12 drinks per year, men and women were compared in terms of the proportions who had stopped drinking because of alcohol problems. Overall, 24% of the male drinkers and 31% of the female drinkers had stopped drinking as of the time of interview...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(94)90010-8
更新日期:1994-08-01 00:00:00
abstract:INTRODUCTION:Smoking prevalence among those in substance misuse treatment remains much higher than the general population, despite evidence for effective cessation interventions that do not negatively impact substance misuse outcomes. This systematic review summarises qualitative data on barriers and facilitators to sm...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2017.07.043
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Some US payers are starting to vary payment to providers depending on patient outcomes, but this approach is rarely used in substance use disorder (SUD) treatment. PURPOSE:We examine the feasibility of applying a pay-for-outcomes approach to SUD treatment. METHODS:We reviewed several relevant literatures: ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2019.107735
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Functional neuroimaging studies have shown that specific brain areas are associated with alcohol craving including the dorsolateral prefrontal cortex (DLPFC). We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol depend...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2007.06.011
更新日期:2008-01-01 00:00:00