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The role of subjective responses in electronic cigarette uptake and substitution in adult smokers.

Abstract：

BACKGROUND:While a majority of cigarette smokers who use electronic cigarettes (e-cigarettes) choose to continue using cigarettes, completely switching to e-cigarettes is necessary to reduce tobacco-related harm. Whether specific subjective responses to e-cigarettes are associated with extent of smoking reduction and complete switching from cigarettes to e-cigarettes is unclear. This study determined whether initial subjective responses to e-cigarettes related to the successful substitution of e-cigarettes for cigarettes and extent of cigarette and e-cigarette use. METHODS:Adult cigarette smokers (N = 58) uninterested in quitting were asked to completely substitute their cigarettes with an e-cigarette (Vuse Solo) for 8 weeks. At week 1, subjective responses to e-cigarettes were measured using the Product Evaluation Scale and Drug Effects/Liking Survey. A Poisson regression examined whether any of these initial subjective responses were associated with smoke-free days, e-cigarette puffs, and cigarettes smoked between weeks 6 and 8 after adjustment for potential confounders. A logistic regression examined the relationship between subjective measures and exhaled carbon monoxide (CO) verified 7-day abstinence at week 8 after adjustment for potential confounders. RESULTS:Following Holm's p-value adjustment, e-cigarette liking and desire were associated with increased e-cigarette use (adjusted p < 0.01) and decreased cigarette use (adjusted p < 0.05). Measures of psychological reward and drug liking were associated with 7-day abstinence, however this association was no longer significant following p-value adjustment. CONCLUSIONS:Initial subjective responses were related to cigarette and e-cigarette use at weeks 6-8, but not smoke-free days or CO-verified 7-day abstinence.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Gades MS,Petersen A,Meier E,Lindgren BR,O'Connor RJ,Shields PG,Hatsukami D

doi

10.1016/j.drugalcdep.2020.107999

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

107999

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(20)30164-2

journal_volume

212

pub_type

杂志文章

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The role of subjective responses in electronic cigarette uptake and substitution in adult smokers.