Abstract:
:The prevalence of cannabis use is rising among adolescents, many of whom perceive little risk from cannabis. However, clinicians who treat adolescent substance users hear frequent reports of serious cannabis-use disorders and problems. This study asked whether cannabis produced dependence and withdrawal among such patients, and whether patients' reports supported previous laboratory findings of reinforcing effects from cannabis. This was a screening and diagnostic study of serial treatment admissions. The diagnostic standard was the DSM-III-R dependence criteria, and the setting was a university-based adolescent substance treatment program with male residential and female outpatient services. The patients were 165 males and 64 females from consecutive samples of 255 male and 85 female 13-19-year-olds referred for substance and conduct problems (usually from social service or criminal justice agencies). Eighty-seven patients were not evaluated, usually due to early elopement. Twenty-four others did not meet study admission criteria: > or = one dependence diagnoses and > or = three lifetime conduct-disorder symptoms. The main measures were items from diagnostic interview instruments for substance dependence, psychiatric disorders, and patterns of substance use. Diagnoses were substance dependence, 100%; current conduct disorder, 82.1%; major depression, 17.5%; attention-deficit/hyperactivity disorder, 14.8%. The results show that most patients claimed serious problems from cannabis, and 78.6% met standard adult criteria for cannabis dependence. Two-thirds of cannabis-dependent patients reported withdrawal. Progression from first to regular cannabis use was as rapid as tobacco progression, and more rapid than that of alcohol, suggesting that cannabis is a reinforcer. The data indicate that for adolescents with conduct problems cannabis use is not benign, and that the drug potently reinforces cannabis-taking, producing both dependence and withdrawal. However, findings from this severely affected clinical population should not be generalized broadly to all other adolescents.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Crowley TJ,Macdonald MJ,Whitmore EA,Mikulich SKdoi
10.1016/s0376-8716(98)00003-9subject
Has Abstractpub_date
1998-03-01 00:00:00pages
27-37issue
1eissn
0376-8716issn
1879-0046pii
S0376871698000039journal_volume
50pub_type
杂志文章abstract:BACKGROUND:Quantity and frequency of drinking may be used to effectively quantify the severity of alcohol-use. Drinking-severity has been related to neurocognitive impairments in such domains as spatial working memory (SWM). Youth drinking has been associated with altered neurofunctional underpinnings of SWM. The curre...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.03.030
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatmen...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.drugalcdep.2018.08.020
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Recent years have seen a rise in the diversity and use of synthetic cannabinoids. The present study evaluated the behavioral effects of the third-generation indazole-3-carboxamide-type synthetic cannabinoid, AB-FUBINACA. METHODS:Adult male and female C57BL/6J mice were treated with AB-FUBINACA (0-3 mg/kg, i...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108179
更新日期:2020-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.07.007
更新日期:2019-10-01 00:00:00
abstract::Data from research on traffic accident populations clearly indicate that a large proportion of accidents involve drivers under the age of twenty-five. Even after differential exposure to traffic accidents has been controlled for, young drivers remain over-represented in both alcohol-related and non-alcohol-related tra...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(82)90084-9
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:Polysubstance use is common in substance users, and may complicate their clinical course. This study, in a criminal justice setting in Sweden, examines the association between the number of concurrently used substance types and psychiatric symptoms during 30 days before incarceration, while controlling for b...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.02.014
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:States have attempted to reduce prescription opioid abuse through strengthening the regulation of pain management clinics; however, the effect of such measures remains unclear. We quantified the impact of Texas's September 2010 "pill mill" law on opioid prescribing and utilization. METHODS:We used the IMS H...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.12.025
更新日期:2016-02-01 00:00:00
abstract::There has been a considerable increase in the number of intravenous amphetamine misusers during the last decade, and the development of effective treatment strategies for this high-risk group has become critical. The use of substitute prescribing is one option, but reservations have been expressed as to its demonstrat...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00052-0
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:In recent decades, smoking has become an increasingly non-normative behavior. Because deviant behaviors are associated with greater clinical and genetic risks, current-generation smokers may have greater concentrations of psychiatric comorbidity than previous generations. We examined this question empiricall...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.08.025
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) and cannabis use are each associated with specific cognitive deficits. Few studies have investigated the neurocognitive profile of individuals with both an ADHD history and regular cannabis use. The greatest cognitive impairment is expected among ADHD Cannabis ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.08.001
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the factors associated with drinking behavior of cancer survivors after cancer diagnosis. METHODS:The study subjects were 906 adult cancer survivors who had reportedly drunk alcohol before cancer diagnosis and participated in the Korean National Health and Nutrition Examination ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.11.024
更新日期:2017-02-01 00:00:00
abstract::Halazepam administered chronically to dogs in oral doses of 180 and 450 mg/kg/day produced physical dependence which was revealed by a flumazenil precipitated abstinence syndrome and measured by the Nordiazepam Precipitated Abstinence Scale score (NPAS) (McNicholas et al., 1988; Sloan et al., 1990). This abstinence as...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(91)90058-7
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Providing needles to people who inject drugs is a well-proven public health response to the transmission of HIV and other blood borne viruses. Despite over a quarter of a century of research, new concerns about potential unintended negative consequences of needle distribution continue to emerge. Specifically...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.11.022
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Previous research has demonstrated how negative affect (i.e., depression, anxiety, stress) is often a correlate of and precursor to nicotine dependence. Although recent evidence shows a gradual decline in tobacco use in the United States, subgroups that report higher levels of negative affect may continue to...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.107883
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Brief motivational intervention (BMI) is one of the few effective strategies targeting alcohol consumption, but has not been tested in young men in the community. We evaluated the efficacy of BMI in reducing alcohol use and related problems among binge drinkers and in maintaining low-risk drinking among non-...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2010.07.009
更新日期:2011-01-01 00:00:00
abstract::Prolactin (PRL) and thyrotropin (TSH) serum levels were determined in a group of young female heroin addicts treated in hospital with methadone in tapered doses. At admission, from 24 to 3 h after the last dose of 'street' heroin, basal PRL values were 21 +/- 2.6 ng/ml, i.e. significantly higher (P less than 0.001) th...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(87)90034-2
更新日期:1987-11-30 00:00:00
abstract::The present study describes a detoxification method which takes only 4 h to complete. Eleven polydrug users addicted to opiates were detoxified 12 h after their last dose of heroin, in an intensive care unit. The detoxification was carried out using naltrexone, after sedation with midazolan. After detoxification (12 h...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(94)90115-5
更新日期:1994-04-01 00:00:00
abstract::The present study compared pregnant drug-dependent women reporting homelessness (n=117) or being domiciled (n=118) at treatment enrollment on initial psychosocial functioning and subsequent drug treatment outcome. Homeless pregnant women presented with greater drug use and medical problems, less social service income,...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(02)00229-6
更新日期:2003-01-24 00:00:00
abstract:OBJECTIVE:The present study examined the dimensionality of DSM-IV Alcohol Use Disorder (AUD) criteria using Item Response Theory (IRT) methods and tested the validity of the proposed DSM-V AUD guidelines in a sample of college students. METHOD:Participants were 396 college students who reported any alcohol use in the ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.03.021
更新日期:2011-11-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.07.041
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated a preventive effect of continuous environmental enrichment during early development on the vulnerability of rodents to drug addiction-related behaviors. Recently, it was demonstrated that a continuous environmental enrichment could eliminate already established addiction-re...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.12.026
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (THC) and cannabidiol (CBD). METHODS:Using a voxel based morphometry approach optimized for small subcortical structures (D...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.09.020
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Recent research has called upon investigators to exploit cross-national differences to uncover the cultural and structural factors influencing drug use. While the individual-level correlates are well-established, little is known about the association between cross-national variation in drug policies and yo...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2012.12.012
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the hypothesis that desipramine would be an effective treatment in cocaine abusers with current depressive disorders. METHOD:This was a randomized, 12-week, double-blind, 'placebo-controlled trial of outpatients (N = 111) meeting DSM-III-R criteria for cocaine dependence and...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2005.03.026
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:While there have been reductions in rates of tobacco use in the general population in recent years, rates remain high among sexual minority populations (SMP). Prior studies often group SMP as one category due to limited data. This study examined the association between sexual identity status and tobacco use ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107684
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Several studies indicate an association between e-cigarette use and subsequent smoking among youth. However, most previous studies lack measures of the nicotine content of e-liquid and have not usually measured regular smoking. METHODS:We tested the association between e-cigarette use, with and without nico...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.04.019
更新日期:2019-08-01 00:00:00
abstract::We adapted the 32-item Verona Service Satisfaction Scale (VSSS-32) to assess opioid-dependent patient satisfaction with services received from methadone treatment centres. The preliminary version of the VSSS for methadone treatment (VSSS-MT) was filled out anonymously and completed by 516 randomly recruited patients. ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(02)00196-5
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Many studies have revealed a widespread pattern of gray matter (GM) atrophy by using voxel-based morphometry (VBM) studies involving the pathophysiology of alcohol dependence. However, the spatial localization of GM abnormalities reported in previous studies is heterogeneous. Here, we aimed to investigate th...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,meta分析
doi:10.1016/j.drugalcdep.2015.05.030
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Prior research demonstrates that individuals who consume alcohol show diminished inhibitory control towards alcohol-related cues. However, such research contrasts predominantly alcoholic appetitive cues with non-alcoholic, non-appetitive cues (e.g., stationary items). As such, it is not clear whether it is s...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.07.038
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Ethanol and cocaine are widely abused drugs triggering long-lasting changes in neuronal circuits and synaptic transmission through the regulation of enzyme activity and gene expression. Compelling evidence indicates that the ubiquitin-proteasome system plays a role in the molecular changes induced by addicti...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.02.012
更新日期:2016-04-01 00:00:00