Abstract:
:The present experiment investigated contextual renewal of cocaine seeking and potential methods of attenuating this renewal. Rats were first trained in one context to self-administer cocaine when a discriminative stimulus (tone) was presented. Then, the ABA Group was placed in a second context and responses in tone no longer produced cocaine (extinction). The AAA Group received this extinction in the original context. For two additional groups, responding to the tone was eliminated in a second context by additionally presenting food in tone according to a differential-reinforcement-of-other-behavior (DRO Group) schedule or independently of the rats' behavior on a fixed-time (FT Group) schedule. Renewal of responding to the tone was observed when the ABA Group was returned to the original context for a renewal test, but no renewal was observed in the AAA Group. Renewal also occurred in the DRO and FT Groups upon returning to the original context, but this renewal was significantly less than that of the ABA Group. These results suggest that response elimination techniques that are more active than simple extinction, such as pairing drug-related stimuli with alternative reinforcement, could reduce renewal of drug seeking and thereby help prevent relapse.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Kearns DN,Weiss SJdoi
10.1016/j.drugalcdep.2007.03.006subject
Has Abstractpub_date
2007-10-08 00:00:00pages
193-202issue
2-3eissn
0376-8716issn
1879-0046pii
S0376-8716(07)00147-0journal_volume
90pub_type
杂志文章abstract::A statistical analysis of the MAST scores obtained by its administration to industrial workers, hospitalized alcoholics and persons arrested driving while intoxicated has been performed. The author discusses the modalities and possibilities of improving the test reliability which will increase its efficiency in the sc...
journal_title:Drug and alcohol dependence
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更新日期:1989-12-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:2003-06-05 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(00)00211-8
更新日期:2001-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.05.048
更新日期:2017-10-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.03.016
更新日期:2018-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(01)00175-2
更新日期:2002-02-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:1986-06-01 00:00:00
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2020.108209
更新日期:2020-11-01 00:00:00
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2020.108401
更新日期:2021-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2015.11.019
更新日期:2016-03-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-03-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2003-07-20 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.05.019
更新日期:2019-10-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.08.039
更新日期:2016-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2009.12.027
更新日期:2010-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2009.06.002
更新日期:2009-10-01 00:00:00
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journal_title:Drug and alcohol dependence
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doi:10.1016/j.drugalcdep.2014.01.026
更新日期:2014-04-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2011.10.032
更新日期:2012-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.11.012
更新日期:2013-08-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-07-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.06.029
更新日期:2014-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2010.06.020
更新日期:2011-01-01 00:00:00
abstract::Previous studies have demonstrated that administration of nonspecific opioid antagonists such as naltrexone or naloxone reduces ethanol-induced locomotor activity in mice. However, because of their broad pharmacological profile, it remains unclear through which opioid receptor this antagonism is achieved. Therefore, t...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2004.11.007
更新日期:2005-06-01 00:00:00