Abstract：
:A group of adolescent drug "experimenters" as defined by the frequency of use (N = 496) were compared to non-users (N = 2417) and to "regular" users (N = 125) on a number of variables. These covered the patterns of use, attitudes to drug use, exposure to drugs and to drug use, and other behavioural correlates. Experimenting with drugs seems to indicate an unfavourable shift in adolescent behaviour. Experimenters were more likely to resemble regular users especially with respect to the behavioural correlates. In the light of the results observed, the various contexts in which the term "experimenting" is currently being used are examined with the conclusion that usage of the term remains to be ambiguous, over-inclusive, unjustified, and should be abandoned.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Swadi Hdoi
10.1016/0376-8716(90)90127-zsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
189-94issue
2eissn
0376-8716issn
1879-0046pii
0376-8716(90)90127-Zjournal_volume
26pub_type
杂志文章abstract：:The present experiment investigated contextual renewal of cocaine seeking and potential methods of attenuating this renewal. Rats were first trained in one context to self-administer cocaine when a discriminative stimulus (tone) was presented. Then, the ABA Group was placed in a second context and responses in tone no...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.03.006
更新日期：2007-10-08 00:00:00
abstract：BACKGROUND:Recent clinical studies support the use of 3,4-methylenedioxymethamphetamine (MDMA) as an adjunct treatment for posttraumatic stress disorder (PTSD). Despite these promising findings, MDMA administration in controlled settings can increase blood pressure, heart rate, and body temperature. Previous studies in...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.107850
更新日期：2020-03-01 00:00:00
abstract：:Opioid receptors are critical therapeutic targets for medications development relevant to the treatment of drug dependence and pain. With recent advances in molecular neurobiology, it has become evident that the functional activity of opioid receptors, as ligand-regulated protein complexes, is modulated by multifariou...
journal_title：Drug and alcohol dependence
pub_type： 社论
doi：10.1016/j.drugalcdep.2010.03.001
更新日期：2010-05-01 00:00:00
abstract：:There has been a considerable increase in the number of intravenous amphetamine misusers during the last decade, and the development of effective treatment strategies for this high-risk group has become critical. The use of substitute prescribing is one option, but reservations have been expressed as to its demonstrat...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(98)00052-0
更新日期：1998-09-01 00:00:00
abstract：AIM:To examine how buprenorphine is currently being used across Italy, and to identify simultaneously best practice protocols to guide physicians in optimising the safety and efficacy of this treatment option. DESIGN:Retrospective, observational, multi-centre study. PARTICIPANTS:A total of 979 opioid-dependent patien...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2007.10.017
更新日期：2008-04-01 00:00:00
abstract：:The N-1 alkyl side chain of the aminoalkylindole analogues (AAI) has been implicated as one of a three-point interaction with the cannabinoid CB(1) receptor. In this study, the morpholinoethyl of WIN 55,212-2 was replaced with carbon chains of varying lengths ranging from a methyl to heptyl group. Additional groups we...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(99)00152-0
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Studies have shown intimate injection partners engage in higher rates of syringe and injecting equipment sharing. We examined the drug use context and development of injection drug use behaviors within intimate injection partnerships. METHODS:In-depth interviews (n=18) were conducted with both members of ni...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.09.025
更新日期：2015-11-01 00:00:00
abstract：:Synaptosomal plasma membrane (SPM), like other plasma membranes, is composed of lipids and proteins and appears to conform to the "fluid mosaic" model proposed by Singer and Nicolson. SPM components show a marked asymmetry with respect to their inside-outside distribution, with the majority of proteins being external....
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90064-4
更新日期：1979-01-01 00:00:00
abstract：INTRODUCTION:"Dabbing" involves heating extremely concentrated forms of marijuana to high temperatures and inhaling the resulting vapor. We studied themes describing the consequences of using highly concentrated marijuana by examining the dabbing-related content on Twitter. METHODS:Tweets containing dabbing-related ke...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.06.034
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:The NIDA Collaborative Cocaine Treatment Study yielded different efficacies for different psychosocial treatments for cocaine dependence. However, substantial heterogeneity of patient outcomes was evident. Longitudinal data analysis techniques can be helpful in examining differential effects of psychosocial ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2009.08.009
更新日期：2010-01-15 00:00:00
abstract：BACKGROUND:Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatmen...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.drugalcdep.2018.08.020
更新日期：2018-12-01 00:00:00
abstract：:The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these recept...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90007-3
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:In laboratory animals, augmentation of GABA neurotransmission results in inhibition of cocaine self-administration and inhibition of reinstatement to cocaine-seeking behaviors. If parallel effects were observed in humans, GABA-ergic medication should be effective both in the abstinence-induction as well as i...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2005.07.009
更新日期：2006-02-28 00:00:00
abstract：INTRODUCTION:Drug dealing among drug users has been associated with elevated risk-taking and negative health outcomes. However, little is known about the cessation of drug dealing among this population. METHODS:We assessed time to cessation of drug dealing using Cox regression. We also used generalized estimating equa...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.05.008
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Research suggests that outcomes associated with drinking may differ depending upon patterns of consumption, drinking related symptoms and social problems. This paper investigated socioeconomic predictors (measuring multiple indices, period and consistency of disadvantage) of midlife drinking patterns. METHO...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2008.01.014
更新日期：2008-06-01 00:00:00
abstract：:Trends in self-reported substance use in surveys of Greek adolescent students show that regular tobacco smoking increased in 1998 (20.8%) after having fallen between 1984 (22%) and 1993 (14.6%). Frequent alcohol consumption decreased in 1998 to 12.1%, from around 15% in both previous surveys. A sharp increase was obse...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(99)00100-3
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Heavy alcohol consumption may accelerate the progression of hepatitis C-related liver disease and/or limit efforts at antiviral treatment in opioid-dependent patients receiving heroin-assisted treatment (HAT). Our study aims to assess alcohol intake among HAT patients by self-reports compared to direct ethan...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.020
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Recent findings suggest that overreliance on habit may be common in individuals diagnosed with addiction. To advance our understanding of habit in clinical samples and from behavioral measures, this study examines the interrelations between self-reported habit index for smoking and drinking as well as behavi...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107738
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Cannabidiol, a therapeutic with potential serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A receptor agonist activity, is the second most prevalent cannabinoid in Cannabis after Δ(9)-THC. The extent to which cannabidiol modifies the effects of Δ(9)-THC has not been firmly established, especially with respect to a...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.05.016
更新日期：2016-08-01 00:00:00
abstract：:Fifteen psychosocial characteristics of 300 male and 90 female heroin addicts admitted for inpatient detoxification, ambulatory detoxification, and methadone maintenance within the same multiphasic drug-abuse program were compared to determine whether or not their characteristics differentiated those seeking each type...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(79)90072-3
更新日期：1979-09-01 00:00:00
abstract：BACKGROUND:Little is known about risk factors for repeated opioid overdose and fatal opioid overdose in the first year following nonfatal opioid overdose. METHODS:We identified a national retrospective longitudinal cohort of patients aged 18-64 years in the Medicaid program who received a clinical diagnosis of nonfata...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.06.004
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Although neighborhoods with more collective efficacy have better health in general, recent work suggests that social norms and collective efficacy may in combination influence health behaviors such as smoking. METHODS:Using data from the New York Social Environment Study (conducted in 2005; n=4000), we exam...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2008.09.012
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (can...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.05.024
更新日期：2018-09-01 00:00:00
abstract：:Infant rats, treated intracisternally with 6-hydroxydopamine or 5,7-dihydroxytryptamine, alone or in combination with desmethylimipramine or pargyline, at 5 to 7 days of age, had significant specific depletions of brain norepinephrine, dopamine, both of these amines, or serotonin at 2.5 months of age. Despite apparent...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(77)90037-0
更新日期：1977-09-01 00:00:00
abstract：BACKGROUND:Differences in fronto-striatal connectivity in problem substance users have suggested reduced influence of cognitive regions on reward-salience regions. Youth with a family history of alcoholism (FH+) have disrupted ventral striatal processing compared with controls with no familial risk (FH-). As sensation-...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.08.019
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Dependent drug users show a diminished neural response to punishment, in both limbic and cortical regions, though it remains unclear how such changes influence cognitive processes critical to addiction. To assess this relationship, we examined the influence of monetary punishment on inhibitory control and ad...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.05.027
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Women who sell sex and use drugs have dual risks for HIV infection. Despite increasing reports of drug use among female sex workers (FSW) in Vietnam, FSW HIV interventions remain focused mainly on sexual risk reduction. We assessed the impact of drug use and inconsistent condom use on HIV infection among FSW ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.02.006
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Several studies indicate an association between e-cigarette use and subsequent smoking among youth. However, most previous studies lack measures of the nicotine content of e-liquid and have not usually measured regular smoking. METHODS:We tested the association between e-cigarette use, with and without nico...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.04.019
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:While a majority of cigarette smokers who use electronic cigarettes (e-cigarettes) choose to continue using cigarettes, completely switching to e-cigarettes is necessary to reduce tobacco-related harm. Whether specific subjective responses to e-cigarettes are associated with extent of smoking reduction and c...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.107999
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Respondent driven sampling (RDS) and incentivized snowball sampling (ISS) are two sampling methods that are commonly used to reach people who inject drugs (PWID). METHODS:We generated a set of simulated RDS samples on an actual sociometric ISS sample of PWID in Vilnius, Lithuania ("original sample") to asse...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.11.020
更新日期：2014-02-01 00:00:00
