当前位置： SCI文献检索 > DRUG AND ALCOHOL DEPENDENCE期刊下所有文献 > Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence.

Genetic vulnerability to schizophrenia is associated with cannabis use patterns during adolescence.

Abstract：

BACKGROUND:Previously reported comorbidity between schizophrenia and substance use may be explained by shared underlying risk factors, such as genetic background. The aim of the present longitudinal study was to investigate how a genetic predisposition to schizophrenia was associated with patterns of substance use (cannabis use, smoking, alcohol use) during adolescence (comparing ages 13-16 with 16-20 years). METHOD:Using piecewise latent growth curve modelling in a longitudinal adolescent cohort (RADAR-Y study, N = 372), we analyzed the association of polygenic risk scores for schizophrenia (PRS; p-value thresholds (pt) < 5e-8 to pt < 0.5) with increase in substance use over the years, including stratified analyses for gender. Significance thresholds were set to adjust for multiple testing using Bonferroni at p ≤ 0.001. RESULTS:High schizophrenia vulnerability was associated with a stronger increase in cannabis use at age 16-20 (PRS thresholds pt < 5e-5 and pt < 5e-4; pt < 5e-6 was marginally significant), whereas more lenient PRS thresholds (PRS thresholds pt < 5e-3 to pt < 0.5) showed the reverse association. For smoking and alcohol, no clear relations were found. CONCLUSIONS:In conclusion, our findings support a relation between genetic risk to schizophrenia and prospective cannabis use patterns during adolescence. In contrast, no relation between alcohol and smoking was established.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Hiemstra M,Nelemans SA,Branje S,van Eijk KR,Hottenga JJ,Vinkers CH,van Lier P,Meeus W,Boks MP

doi

10.1016/j.drugalcdep.2018.05.024

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

143-150

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(18)30339-9

journal_volume

190

pub_type

杂志文章

相关文献

DRUG AND ALCOHOL DEPENDENCE文献大全
  • Needle sharing in regular sexual relationships: an examination of serodiscordance, drug using practices, and the gendered character of injecting.

    abstract：BACKGROUND:This paper examines correlates of needle and other equipment sharing among injecting drug users (IDU) in regular heterosexual relationships. METHODS:A cross-sectional survey collected data from people obtaining sterile needles and syringes from pharmacies in New South Wales, Australia. 181 IDU in regular he...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2009.10.007

    authors： Bryant J,Brener L,Hull P,Treloar C

    更新日期：2010-03-01 00:00:00

  • Immunoheterogeneity of serum calcitonin in heroin addicts.

    abstract：:Serum calcitonin (CT) concentrations were determined in 96 heroin addicts. CT levels were assayed by radioimmunological method employing two antisera, one vs. the 17-32 fraction (IMN) of the human CT, the other vs. the 11-32 fraction (B7). In heroin addicts the CT mean values were significantly higher (P less than 0.0...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(88)90052-x

    authors： Spagnolli W,DeVenuto G,Mattarei M,DalPiaz A,Merz O,Miori R

    更新日期：1988-10-01 00:00:00

  • Utilization of communication technology by patients enrolled in substance abuse treatment.

    abstract：BACKGROUND:Technology-based applications represent a promising method for providing efficacious, widely available interventions to substance abuse treatment patients. However, limited access to communication technology (i.e., mobile phones, computers, internet, and e-mail) could significantly impact the feasibility of ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2012.10.003

    authors： McClure EA,Acquavita SP,Harding E,Stitzer ML

    更新日期：2013-04-01 00:00:00

  • Subjective, cognitive/psychomotor, and physiological effects of aripiprazole in Chinese light and heavy smokers.

    abstract：BACKGROUND:Drug addiction researchers have begun to study dopamine partial agonists as potential therapeutic agents. The partial dopamine D(2) receptor agonist aripiprazole has recently been tested as a treatment for stimulant and alcohol dependence in both animal and clinical studies. METHODS:A randomized and placebo...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2008.10.024

    authors： Liu Y,Sun HQ,Bao YP,Li SX,Beveridge TJ,Di XL,Yang FD,Lu L

    更新日期：2009-04-01 00:00:00

  • The changes in sulfhydryl compounds in plasma, liver and brain after acute and chronic ethanol administration in rats.

    abstract：:The content of sulfhydryl compounds in proteins and non-proteins of plasma, liver and brain after acute and chronic ethanol administration was investigated in rats. After ethanol ingestion for 4 weeks (6 g/kg, day 30% w/v) significant changes were observed in plasma proteins and in liver proteins and non-proteins. In ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(87)90061-5

    authors： Farbiszewski R,Holownia A,Chwiecko M

    更新日期：1987-11-01 00:00:00

  • Post-exposure prophylaxis use and recurrent exposure to HIV among men who have sex with men who use crystal methamphetamine.

    abstract：BACKGROUND:Men who have sex with men (MSM) who use crystal methamphetamine (CM) are at increased risk for HIV infection. Post-exposure prophylaxis (PEP) is a useful HIV prevention strategy if individuals are able to identify high-risk exposures and seek timely care, however to date there has been limited data on the us...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.11.010

    authors： Oldenburg CE,Jain S,Mayer KH,Mimiaga MJ

    更新日期：2015-01-01 00:00:00

  • Developmental lead exposure alters methamphetamine self-administration in the male rat: acquisition and reinstatement.

    abstract：:The rate of acquisition of drug self-administration and the return to drug seeking are important elements of the overall drug profile, and are essential factors in understanding risks associated with drug abuse. Experiment 1 examined the effects of perinatal (gestation/lactation) lead exposure on adult rates of acquis...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2007.12.003

    authors： Rocha A,Valles R,Bratton GR,Nation JR

    更新日期：2008-05-01 00:00:00

  • The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine.

    abstract：BACKGROUND:Clock genes have been demonstrated to play a role in behavioral responses to a variety of drugs of abuse, including cocaine, amphetamine, morphine, and ethanol. However, no studies to date have examined the role of Clock genes on nicotine-mediated behaviors. We examined the involvement of Clock, one of sever...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2013.08.024

    authors： Bernardi RE,Spanagel R

    更新日期：2013-12-01 00:00:00

  • Positive smoker identity as a barrier to quitting smoking: findings from a national survey of smokers in England.

    abstract：BACKGROUND:It has been proposed that positive smoker identity may be an important factor undermining smoking cessation but very little research exists on this. This study tested the hypothesis that a simple measure of positive smoker identity would predict quit attempts over and above other known predictors in a popula...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2013.09.001

    authors： Tombor I,Shahab L,Brown J,West R

    更新日期：2013-12-01 00:00:00

  • Educational disadvantage and cigarette smoking during pregnancy.

    abstract：:This study examined the influence of education on smoking status in a cohort (n=316) of pregnant women who were smokers at the time they learned of the current pregnancy. Subjects were participants in clinical trials examining the efficacy of monetary-based incentives for smoking-cessation and relapse prevention. In m...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.drugalcdep.2009.03.013

    authors： Higgins ST,Heil SH,Badger GJ,Skelly JM,Solomon LJ,Bernstein IM

    更新日期：2009-10-01 00:00:00

  • Alcohol high risk drinking, abuse and dependence among tobacco smoking medical care patients and the general population.

    abstract：BACKGROUND:Little is known about the synergies of smoking and alcohol consumption in medical care patients. The objective, therefore, is to estimate the coincidence of hazardous and harmful alcohol consumption as well as alcohol abuse and dependence with tobacco smoking in a general hospital and general practices. MET...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(02)00315-0

    authors： John U,Hill A,Rumpf HJ,Hapke U,Meyer C

    更新日期：2003-03-01 00:00:00

  • Data compatibility in the addiction sciences: an examination of measure commonality.

    abstract：:The need for comprehensive analysis to compare and combine data across multiple studies in order to validate and extend results is widely recognized. This paper aims to assess the extent of data compatibility in the substance abuse and addiction (SAA) sciences through an examination of measure commonality, defined as ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.04.029

    authors： Conway KP,Vullo GC,Kennedy AP,Finger MS,Agrawal A,Bjork JM,Farrer LA,Hancock DB,Hussong A,Wakim P,Huggins W,Hendershot T,Nettles DS,Pratt J,Maiese D,Junkins HA,Ramos EM,Strader LC,Hamilton CM,Sher KJ

    更新日期：2014-08-01 00:00:00

  • Educational differences in alcohol consumption and heavy drinking: An age-period-cohort perspective.

    abstract：BACKGROUND:Low socioeconomic status (SES) has been associated with lower alcohol consumption, but also with heavier drinking. To explain this contradictory relationship, we examined SES differences in drinking patterns from an age-period-cohort (APC) perspective. METHODS:Data are from seven waves of the U.S. National ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.12.046

    authors： Lui CK,Kerr WC,Mulia N,Ye Y

    更新日期：2018-05-01 00:00:00

  • The role of negative affect in the persistence of nicotine dependence among alternative high school students: A latent growth curve analysis.

    abstract：BACKGROUND:Previous research has demonstrated how negative affect (i.e., depression, anxiety, stress) is often a correlate of and precursor to nicotine dependence. Although recent evidence shows a gradual decline in tobacco use in the United States, subgroups that report higher levels of negative affect may continue to...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107883

    authors： Miller S,Pike J,Shono Y,Beleva Y,Xie B,Stacy AW

    更新日期：2020-04-01 00:00:00

  • An evaluation of a behaviour therapy programme as an intervention treatment for the fear of withdrawal with heroin-dependent persons.

    abstract：:A methadone withdrawal programme (MWP) and a behaviour therapy programme (BTP) were compared in terms of their effectiveness to prevent relapse of heroin addicts after methadone treatment. The BTP incorporated systematic desensitization to effect a decrease in levels of fear of both physical and environmental withdraw...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(80)90193-3

    authors： Hollonds GB,Oei TP,Turecek LR

    更新日期：1980-02-01 00:00:00

  • Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release.

    abstract：BACKGROUND:Previous imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D2/3) binding and dopamine transmission. Although binge drinking is a risk factor for future AUD, little is known about the neurobiology of...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2019.107627

    authors： Wai JM,Grassetti A,Slifstein M,Matuskey D,Nabulsi N,Ropchan J,Labaree D,Huang Y,Martinez D

    更新日期：2019-12-01 00:00:00

  • Impact of an unsanctioned safe consumption site on criminal activity, 2010-2019.

    abstract：BACKGROUND:Health and social impacts of safe consumption sites (SCS) are well described in multiple countries. One argument used by those opposed to SCS in the US is that findings from other countries are not relevant to the US context. We examined whether an unsanctioned SCS operating in the US affected local crime ra...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2021.108521

    authors： Davidson PJ,Lambdin BH,Browne EN,Wenger LD,Kral AH

    更新日期：2021-01-11 00:00:00

  • Prolactin and thyrotropin pituitary response to thyrotropin releasing hormone in young female heroin addicts.

    abstract：:Prolactin (PRL) and thyrotropin (TSH) serum levels were determined in a group of young female heroin addicts treated in hospital with methadone in tapered doses. At admission, from 24 to 3 h after the last dose of 'street' heroin, basal PRL values were 21 +/- 2.6 ng/ml, i.e. significantly higher (P less than 0.001) th...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(87)90034-2

    authors： Spagnolli W,De Venuto G,Mattarei M,Dal Ri P,Miori R

    更新日期：1987-11-30 00:00:00

  • Multi-centre observational study of buprenorphine use in 32 Italian drug addiction centres.

    abstract：AIM:To examine how buprenorphine is currently being used across Italy, and to identify simultaneously best practice protocols to guide physicians in optimising the safety and efficacy of this treatment option. DESIGN:Retrospective, observational, multi-centre study. PARTICIPANTS:A total of 979 opioid-dependent patien...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.drugalcdep.2007.10.017

    authors： Leonardi C,Hanna N,Laurenzi P,Fagetti R,I.D.A.C. Group.

    更新日期：2008-04-01 00:00:00

  • The influence of legal coercion on dropout from substance abuse treatment: results from a national survey.

    abstract：:Legal coercion is frequently used to leverage substance abuse treatment upon persons who would otherwise not seek it voluntarily. Various methodological and conceptual problems of the existing research have prevented a clear understanding of its effectiveness. The influence of legal coercion on retention in substance ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2007.07.011

    authors： Perron BE,Bright CL

    更新日期：2008-01-01 00:00:00

  • The Network for the Improvement of Addiction Treatment (NIATx): enhancing access and retention.

    abstract：:The Network for the Improvement of Addiction Treatment (NIATx) teaches participating treatment centers to use process improvement strategies. A cross-site evaluation monitored impacts on days between first contact and first treatment and percent of patients who started treatment and completed two, three and four units...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.drugalcdep.2006.10.009

    authors： McCarty D,Gustafson DH,Wisdom JP,Ford J,Choi D,Molfenter T,Capoccia V,Cotter F

    更新日期：2007-05-11 00:00:00

  • Deaths of clients in methadone treatment in Texas: 1994-2002.

    abstract：:This study analyzes causes of deaths of 766 patients who died while in methadone treatment in Texas between 1994 and 2002. Compared with deaths in the general population of Texas, deaths of clients in methadone treatment were 4.6 times more likely to be from a drug overdose, 3.4 times more likely to be from liver dise...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2004.09.006

    authors： Maxwell JC,Pullum TW,Tannert K

    更新日期：2005-04-04 00:00:00

  • Reductions in physical pain predict lower risk of relapse following alcohol treatment.

    abstract：OBJECTIVE:Physical pain is considered a potential predictor of relapse in alcohol-dependent individuals after treatment. The aim of this study was to evaluate whether reductions in pain level during the follow-up period after treatment were associated with lower relapse risk. METHOD:A sample of 366 participants was re...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2015.11.020

    authors： Jakubczyk A,Ilgen MA,Kopera M,Krasowska A,Klimkiewicz A,Bohnert A,Blow FC,Brower KJ,Wojnar M

    更新日期：2016-01-01 00:00:00

  • Cannabis smoking and serum C-reactive protein: a quantile regressions approach based on NHANES 2005-2010.

    abstract：BACKGROUND:Pre-clinical studies link cannabinoid-1 receptor activation to inflammation and atherosclerotic effects; anti-inflammation and immunosuppression seem to be mediated by cannabinoid-2 receptor activation. In this epidemiological study, we aim to present estimates on suspected cannabis-attributable immunomodula...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.11.017

    authors： Alshaarawy O,Anthony JC

    更新日期：2015-02-01 00:00:00

  • Mechanisms for the reduction of caffeine consumption: What, how and why.

    abstract：BACKGROUND:Anecdotal evidence suggests consumers of caffeine self-administer strategies to reduce consumption, but little is known of what these strategies are or how they are implemented. This study aimed to understand the lived experience of reducing caffeine consumption including specific techniques (what) and imple...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.108024

    authors： Rodda S,Booth N,McKean J,Chung A,Park JJ,Ware P

    更新日期：2020-07-01 00:00:00

  • Associations between polysubstance use and psychiatric problems in a criminal justice population in Sweden.

    abstract：BACKGROUND:Polysubstance use is common in substance users, and may complicate their clinical course. This study, in a criminal justice setting in Sweden, examines the association between the number of concurrently used substance types and psychiatric symptoms during 30 days before incarceration, while controlling for b...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2011.02.014

    authors： Hakansson A,Schlyter F,Berglund M

    更新日期：2011-10-01 00:00:00

  • Prevalence and motivations for kratom use in a sample of substance users enrolled in a residential treatment program.

    abstract：BACKGROUND:Kratom use in the West has increased recently, yet the prevalence and motives for use among individuals with a history of substance use disorder (SUD) have not been fully examined. Kratom has been documented as a means of treating chronic pain, mitigating drug dependence, and easing withdrawal symptoms, yet ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.08.034

    authors： Smith KE,Lawson T

    更新日期：2017-11-01 00:00:00

  • The effects of sponsorship in 12-step treatment of injection drug users.

    abstract：:What contributes to sustained abstinence from injection drug use by those who participate in community-based Narcotics Anonymous (NA) and Alcoholics Anonymous (AA) is not well understood. We know that sponsorship is a central element in these programs. To investigate the relationship between sponsorship and abstinence...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(01)00175-2

    authors： Crape BL,Latkin CA,Laris AS,Knowlton AR

    更新日期：2002-02-01 00:00:00

  • Prevalence, correlates, comorbidity, and age of onset of alcohol use disorders in adult males from five provinces in China.

    abstract：BACKGROUND:This study integrates data from high-quality mental health surveys in five provinces in China to examine the prevalence, demographic correlates, age of onset, and comorbidity of alcohol use disorder (AUD). METHODS:The five cross-sectional surveys initially screened a representative sample of 74,752 communit...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.drugalcdep.2016.12.026

    authors： Phillips MR,Cheng HG,Li X,Zhang J,Shi Q,Xu G,Song Z,Ding Z,Pang S

    更新日期：2017-04-01 00:00:00

  • Quitting smoking and change in alcohol consumption in the International Tobacco Control (ITC) Four Country Survey.

    abstract：:Although frequent heavy drinking has been associated with decreased odds of quitting smoking, the extent to which smoking cessation is associated with decreased alcohol consumption is less clear. The present study examined over a 2-year period whether individuals who quit smoking for at least 6 months, compared to tho...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2010.02.008

    authors： Kahler CW,Borland R,Hyland A,McKee SA,O'Connor RJ,Fong GT,Cummings KM

    更新日期：2010-07-01 00:00:00