Abstract：
BACKGROUND:Previous imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D2/3) binding and dopamine transmission. Although binge drinking is a risk factor for future AUD, little is known about the neurobiology of binge drinking in young adults. This study measured D2/3 receptor binding and stimulant-induced dopamine release using PET and [11C]raclopride in binge drinkers without an AUD. METHODS:This study included 14 healthy controls (HC) and 14 young adult binge drinkers (BD), aged 18-25. The BD met National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria for binge drinking and the HC subjects were social drinkers. The subjects were scanned with [11C]raclopride before and after the administration of oral methylphenidate (60 mg) to measure D2/3 binding and dopamine release. RESULTS:There was no significant difference in the PET measures of D2/3 binding or methylphenidate-induced dopamine release between the two groups. There was no significant association between Alcohol Use Disorders Identification Test (AUDIT) scores or 30-day drinking history and the imaging data. CONCLUSION:In this sample of 18-25-year-old binge drinkers without a diagnosis of a substance use disorder, there were no significant differences in D2/3 receptor binding potential or methylphenidate-induced dopamine release relative to healthy controls.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Wai JM,Grassetti A,Slifstein M,Matuskey D,Nabulsi N,Ropchan J,Labaree D,Huang Y,Martinez Ddoi
10.1016/j.drugalcdep.2019.107627subject
Has Abstractpub_date
2019-12-01 00:00:00pages
107627eissn
0376-8716issn
1879-0046pii
S0376-8716(19)30404-1journal_volume
205pub_type
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