Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report.

abstract：BACKGROUND:In laboratory animals, augmentation of GABA neurotransmission results in inhibition of cocaine self-administration and inhibition of reinstatement to cocaine-seeking behaviors. If parallel effects were observed in humans, GABA-ergic medication should be effective both in the abstinence-induction as well as i...

journal_title：Drug and alcohol dependence

authors： Bisaga A,Aharonovich E,Garawi F,Levin FR,Rubin E,Raby WN,Nunes EV

更新日期：2006-02-28 00:00:00

abstract：:Self-reported levels of alcohol consumption were recorded from residents of three areas in Britain with different official rates of drinking problems. Previous publications have shown minor area differences in the drinking habits of both sexes. The present analyses found no significant area differences for each sex in...

journal_title：Drug and alcohol dependence

authors： Crawford A

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Doctor-shopping (obtaining prescriptions from multiple prescribers/pharmacies) for opioid analgesics produces a supply for diversion and abuse, and represents a major public health issue. METHODS:An open cohort study assessed changes in doctor-shopping in the U.S. for a brand extended release (ER) oxycodone...

journal_title：Drug and alcohol dependence

authors： Chilcoat HD,Coplan PM,Harikrishnan V,Alexander L

更新日期：2016-08-01 00:00:00

abstract：:The availability of increasingly sophisticated drug formulations and delivery devices has created new opportunities in drug development. These newer approaches can result in improved drug bioavailability, or they can alter key pharmacokinetic parameters in such a way as to decrease dosing interval, decrease variabilit...

journal_title：Drug and alcohol dependence

authors： Mansbach RS,Moore RA Jr

更新日期：2006-06-01 00:00:00

abstract：:This study examined the predictors of self-reported health status at follow-up in the Drug Abuse Treatment Outcomes Study (DATOS), a longitudinal study of drug abuse treatment programs and patients in 1991-1993. Baseline and follow-up interviews of 2966 patients in 75 programs were performed. The follow-up assessment ...

journal_title：Drug and alcohol dependence

authors： Friedmann PD,Lemon SC,Anderson BJ,Stein MD,Drug Abuse Treatment Outcome Study (DATOS.

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Agonist replacement treatment is a promising strategy to manage cannabis-use disorders. The aim of this study was to assess the combined effects of the synthetic cannabinoid agonist nabilone and Δ⁹-tetrahydrocannabinol (Δ⁹-THC) using drug-discrimination procedures, which are sensitive to drug interactions. T...

journal_title：Drug and alcohol dependence

authors： Lile JA,Kelly TH,Hays LR

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Mental health problems have been identified among soldiers serving in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF), but little is known about the prevalence and management of alcohol misuse in OEF/OIF veterans seen in the Veterans Administration health care system (VA). METHODS:We identified 12,0...

journal_title：Drug and alcohol dependence

authors： Hawkins EJ,Lapham GT,Kivlahan DR,Bradley KA

更新日期：2010-06-01 00:00:00

abstract：:The differences in beliefs about the effects of anabolic steroid (AS) use between AS users and non-users provides potentially important clues to understanding AS use. Two groups of bodybuilders were used in this comparison: AS users (n = 20) and non-users (n = 27). Subjects completed a 40-item scale measuring their be...

journal_title：Drug and alcohol dependence

authors： Schwerin MJ,Corcoran KJ

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Gamma-Hydroxybutyric acid (GHB) is a drug of abuse associated with increasing numbers of GHB-dependent patients and emergency attendances often related to GHB-induced coma. Animal studies suggest that GHB induces oxidative stress in the hippocampus, resulting in memory impairments. However, the consequences ...

journal_title：Drug and alcohol dependence

authors： Raposo Pereira F,McMaster MTB,Polderman N,de Vries YDAT,van den Brink W,van Wingen GA

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The beneficial links between engagement in methadone maintenance therapy (MMT) and HIV treatment outcomes have been extensively described. Nevertheless, people who use drugs (PWUD) continue to experience suboptimal HIV treatment outcomes. In this systematic review, we sought to identify components of MMT ser...

journal_title：Drug and alcohol dependence

authors： Mohd Salleh NA,Voon P,Karamouzian M,Milloy MJ,Richardson L

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the prevalence of injecting drug use and associated risk behaviour among a sentinel sample of ecstasy users. METHODS:Cross-sectional surveys were conducted with regular ecstasy users as part of an annual monitoring study of ecstasy and related drug markets in all Aust...

journal_title：Drug and alcohol dependence

authors： White B,Day C,Degenhardt L,Kinner S,Fry C,Bruno R,Johnston J

更新日期：2006-07-27 00:00:00

abstract：:Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and r...

journal_title：Drug and alcohol dependence

authors： Howes JF,Villarreal JE,Harris LS,Essigmann EM,Cowan A

更新日期：1985-02-01 00:00:00

abstract：:The pharmaceutical industry has made substantial innovations in the area of targeted drug delivery and optimization of pharmacokinetics for existing drugs to try to maximize therapeutic effect while simultaneously minimizing adverse consequences of medication abuse. These innovations, however, have not come without a ...

journal_title：Drug and alcohol dependence

authors： McCormick CG

更新日期：2006-06-01 00:00:00

abstract：:The purpose of the present investigation was to examine the development of tolerance to the effects of morphine and other mu opioids in rats responding under a fixed-consecutive-number (FCN) schedule of food presentation. To this end, five rats were trained under an FCN schedule and subsequently tested with a variety ...

journal_title：Drug and alcohol dependence

authors： Smith MA,Pitts RC,Picker MJ

更新日期：1997-06-06 00:00:00

abstract：OBJECTIVE:The aim of the project was to determine whether children at high risk for alcohol use disorder (AUD) are impaired at performing oculomotor response inhibition tasks sensitive to detecting prefrontal cortex dysfunction. METHODS:Three antisaccade tasks were administered to 67 10-12-year-old children having fat...

journal_title：Drug and alcohol dependence

authors： Habeych ME,Folan MM,Luna B,Tarter RE

更新日期：2006-03-15 00:00:00

abstract：OBJECTIVE:The aims were to determine: (i) quantity and frequency of same-day use of opioids with benzodiazepines and/or alcohol amongst people who regularly tamper with pharmaceutical opioids; and (ii) socio-demographic, mental health, harms and treatment profile associated with same-day use of high doses. METHOD:The ...

journal_title：Drug and alcohol dependence

authors： Peacock A,Bruno R,Larance B,Lintzeris N,Nielsen S,Ali R,Dobbins T,Degenhardt L

更新日期：2016-09-01 00:00:00

abstract：:The drug habits for 78 confirmed opiate addicts were studied on eight scales from the Process Association Test of Addiction (PATA) for many drug names. Through cluster analysis eight stages of addiction were defined: "to be clean", "to learn about drugs", "to hustle", "to chip" (also "to be high"), to be psychological...

journal_title：Drug and alcohol dependence

authors： Haertzen CA,Ross FE

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Stress is thought to contribute to both initiation and relapse to drug abuse. However, the mechanisms by which stress influences drug use are unclear. Interestingly, responses to acute administration of stimulant drugs resemble certain neuronal and hormonal responses to acute stress, and there is accumulatin...

journal_title：Drug and alcohol dependence

authors： Hamidovic A,Childs E,Conrad M,King A,de Wit H

更新日期：2010-06-01 00:00:00

abstract：:Endogenous opioids acting at mu-opioid receptors mediate many biological functions. Pharmacological intervention at these receptors has greatly aided in the treatment of acute and chronic pain, in addition to other uses. However, the development of tolerance and dependence has made it difficult to adequately prescribe...

journal_title：Drug and alcohol dependence

authors： Mague SD,Blendy JA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:This study examined factors associated with marijuana use initiation among never users, prior-to-past year user who return to use, and users who continue use over a 12-month follow-up period. METHODS:Two waves (W1 and W2) of the Population Assessment of Tobacco and Health (PATH) Study provided data (N=26,20...

journal_title：Drug and alcohol dependence

authors： Choi NG,DiNitto DM,Marti CN

更新日期：2018-01-01 00:00:00

abstract：:Serum alcohol dehydrogenase (ADH) activity in some individuals contains a fraction that is not inhibited by pyrazole. This might be due to the presence in those sera of pi-ADH, a unique isoenzyme found recently in human liver, and which, according to one hypothesis, could be co-responsible for the development of alcoh...

journal_title：Drug and alcohol dependence

authors： Skurský L,Khayrollah A

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:In cocaine-dependent individuals, executive function (EF) deficits are associated with poor treatment outcomes. Psychological interventions and pharmacological approaches have produced only modest effect sizes. To date, studies of this topic have been few and limited. The aim of this study was to examine the...

journal_title：Drug and alcohol dependence

authors： Gonçalves PD,Ometto M,Bechara A,Malbergier A,Amaral R,Nicastri S,Martins PA,Beraldo L,dos Santos B,Fuentes D,Andrade AG,Busatto GF,Cunha PJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Genetic influences on smoking cessation treatment outcome may be affected by pretreatment patient characteristics. Nicotine dependence is arguably the most salient clinical factor in smoking cessation. METHODS:In this secondary analysis of clinical trial data (N=793), we examined nicotine dependence severit...

journal_title：Drug and alcohol dependence

authors： Leventhal AM,Lee W,Bergen AW,Swan GE,Tyndale RF,Lerman C,Conti DV

更新日期：2014-05-01 00:00:00

abstract：AIMS:This study investigated the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in a group of chronic ketamine abusers in comparison to healthy controls. The correlations between the serum BDNF, NGF level with the subjects' demographic, pattern of ketamine use were also examined....

journal_title：Drug and alcohol dependence

authors： Ke X,Ding Y,Xu K,He H,Zhang M,Wang D,Deng X,Zhang X,Zhou C,Liu Y,Ning Y,Fan N

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:In order to successfully address excessive alcohol consumption it is essential to have a means of measuring the drinking patterns of a nation. Owing to the multi-dimensional nature of drinking patterns, usual survey methods have their limitations. The aim of this study was to make use of extremely detailed d...

journal_title：Drug and alcohol dependence

authors： Hill-McManus D,Angus C,Meng Y,Holmes J,Brennan A,Sylvia Meier P

更新日期：2014-01-01 00:00:00

abstract：:A standardized questionnaire, with satisfactory retake item reliabilities and well established validities, was administered to a representative sample of female university students (N = 2366), drawn from Cairo and Ein-Shams Universities, both located in Greater Cairo. Results, relevant to demographic and drug related ...

journal_title：Drug and alcohol dependence

authors： Soueif MI,Hannourah MA,Darweesh ZA,el-Sayed AM,Yunis FA,Taha HS

更新日期：1987-05-01 00:00:00

abstract：:Synaptosomal plasma membrane (SPM), like other plasma membranes, is composed of lipids and proteins and appears to conform to the "fluid mosaic" model proposed by Singer and Nicolson. SPM components show a marked asymmetry with respect to their inside-outside distribution, with the majority of proteins being external....

journal_title：Drug and alcohol dependence

authors： Smith AP,Loh HH

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Nutrition is a prerequisite for health; yet, there is no special nutritional assessment or guidance for drug and alcohol dependent individuals, despite the fact that their food consumption is often very limited, risking malnutrition. Further, the premise is examined that malnutrition may promote drug seeking...

journal_title：Drug and alcohol dependence

authors： Jeynes KD,Gibson EL

更新日期：2017-10-01 00:00:00

abstract：:Diagnostic interviews for substance use disorders tend to have high reliability among adults. We examined the inter-rater reliability of the substance use disorders section of the Structured Clinical Interview for the DSM, using 46 male and 25 female adolescent drinkers recruited from community and treatment sources. ...

journal_title：Drug and alcohol dependence

authors： Martin CS,Pollock NK,Bukstein OG,Lynch KG

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Methamphetamine use is associated with a range of poor health, social and justice outcomes. In many parts of the world increased methamphetamine use has been identified as a major public health concern. Methamphetamine treatment programmes have been effective in reducing and ceasing use, however a range of b...

journal_title：Drug and alcohol dependence

authors： Cumming C,Troeung L,Young JT,Kelty E,Preen DB

更新日期：2016-11-01 00:00:00