Abstract:
BACKGROUND:Dependent drug users show a diminished neural response to punishment, in both limbic and cortical regions, though it remains unclear how such changes influence cognitive processes critical to addiction. To assess this relationship, we examined the influence of monetary punishment on inhibitory control and adaptive post-error behavior in abstinent cocaine dependent (CD) participants. METHODS:15 abstinent CD and 15 matched control participants performed a Go/No-go response inhibition task, which administered monetary fines for failed response inhibition, during collection of fMRI data. RESULTS:CD participants showed reduced inhibitory control and significantly less adaptive post-error slowing in response to punishment, when compared to controls. The diminished behavioral punishment sensitivity shown by CD participants was associated with significant hypoactive error-related BOLD responses in the dorsal anterior cingulate cortex (ACC), right insula and right prefrontal regions. Specifically, CD participants' error-related response in these regions was not modulated by the presence of punishment, whereas control participants' response showed a significant BOLD increase during punished errors. CONCLUSIONS:CD participants showed a blunted response to failed control (errors) that was not modulated by punishment. Consistent with previous findings of reduced sensitivity to monetary loss in cocaine users, we further demonstrate that such insensitivity is associated with an inability to increase cognitive control in the face of negative consequences, a core symptom of addiction. The pattern of deficits in the CD group may have implications for interventions that attempt to improve cognitive control in drug dependent groups via positive/negative incentives.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Hester R,Bell RP,Foxe JJ,Garavan Hdoi
10.1016/j.drugalcdep.2013.05.027subject
Has Abstractpub_date
2013-11-01 00:00:00pages
86-93issue
1eissn
0376-8716issn
1879-0046pii
S0376-8716(13)00202-0journal_volume
133pub_type
杂志文章abstract::The aim of the present study is to analyze whether the addition of propylthiouracil reverts the influence of ethanol on the development of periportal and pericentral hepatocytes and their nuclei in male albino mice. Propylthiouracil-treated animals showed decreased cellular and nuclear areas when compared with the con...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(88)90004-x
更新日期:1988-02-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The objective of this study was to assess treatment consumption and re-enrollment in treatment in patients with gamma-hydroxybutyrate (GHB)-dependence in Dutch Addiction Treatment Centers (ATCs) in comparison with other addictions. METHODS:A cohort-study using nationwide administrative data from regular Dut...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2017.02.026
更新日期:2017-07-01 00:00:00
abstract::Investigators on fetal alcohol syndrome (FAS) both clinical and experimental, have generally concentrated attention on chronic alcoholism. In an attempt to elucidate the effects of binge drinking on pre- and postnatal development, single doses of 0.01, 0.02 and 0.03 ml/g body weight of alcohol solutions (25% v/v of et...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(84)90045-0
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) inj...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.12.004
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:E-cigarette use is rapidly increasing, especially among youth and young adults. We need to learn what factors are associated with uptake in e-cigarettes. One important set of predictors is beliefs about e-cigarettes' potential harms and benefits. METHODS:Online survey data were collected in July, 2014 fro...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.11.003
更新日期:2016-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.08.020
更新日期:2013-12-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1996-12-11 00:00:00
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 历史文章,杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.107815
更新日期:2020-03-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2019.07.007
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2008.10.017
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
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更新日期:1980-05-01 00:00:00
abstract:BACKGROUND:Since early in Thailand's HIV epidemic, HIV seroprevalence among injection drug users (IDUs) in Bangkok has been around 40%. As Thailand moves to strengthen HIV prevention and care programs for Bangkok IDUs, information on current patterns of drug use and an estimate of the size and composition of the IDU po...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2007.03.013
更新日期:2007-10-08 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
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更新日期:2003-07-20 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
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journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1997-06-06 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2003.12.010
更新日期:2004-05-10 00:00:00