Abstract：
BACKGROUND:A number of studies have researched the association between monoamine oxidase gene (MAO) polymorphisms and smoking behavior, but the conclusion is quite inconsistent. A meta-analysis was conducted to assess the association of MAO-A C1460T, MAO-A VNTR and MAO-B G644A polymorphisms with smoking behavior. METHODS:A comprehensive search was performed to identify all eligible studies. Meta-analysis was applied to calculate the pooled effect values and their 95% confidence intervals. Meta-regression and the 'leave one out' sensitivity analysis were used to explore potential sources of heterogeneity. The risk of bias was assessed by the Egger regression asymmetry test. RESULTS:11 articles conformed to the inclusion criteria. The meta-analysis showed T allele in MAO-A C1460T reduced the risk of heavy smoking (OR=0.66, 95% CI: 0.52-0.84; I(2)=0.0%), especially in Caucasians; the active group in MAO-A VNTR increased the likelihood of failed smoking cessation in males (OR=1.49, 95% CI: 1.01-2.22; I(2)=0.0%); A allele in MAO-B G644A reduced the risk of heavy smoking in males (OR=0.20, 95% CI: 0.04-0.98). CONCLUSION:Our findings indicate that the low activity of monoamine oxidase gene polymorphisms has a protective effect on smoking cessation and heaviness. Some associations and applications should be further confirmed.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Yang X,Chen H,Li S,Wang Q,Pan L,Jia Cdoi
10.1016/j.drugalcdep.2015.05.024subject
Has Abstractpub_date
2015-08-01 00:00:00pages
350-4eissn
0376-8716issn
1879-0046pii
S0376-8716(15)00260-4journal_volume
153pub_type
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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