Abstract：
:The sites of action of naloxone and the possible interaction between supraspinally and spinally administered naloxone in precipitating withdrawal jumping were investigated by comparing the ED50 value and central nervous system (CNS) content of naloxone after three different administration routes in morphine-dependent mice. ED50 values of naloxone for i.c.v., i.t. and s.c. routes were 18.8 nmol, 1.95 nmol and 50.6 nmol/kg, respectively. Jumping occurred most often within 5 min after i.t administered naloxone, but it took more than 10 min to reach the most frequent jumping after s.c. and i.c.v. administered naloxone. After equi-effective doses (ED50) of naloxone were administered i.c.v., i.t. or s.c., the content of naloxone in the brain was 70 times lower after s.c. than that after i.c.v. injection. The concentration of naloxone in the spinal cord was 37 times lower after s.c. than that after i.t. injection. The ED50 values of naloxone and the time courses of jumping suggest that spinal sites appear to be more important than the supraspinal sites and comparisons of naloxone-content suggest that there is a synergistic interaction between supraspinal- and spinal-naloxone after systemic administration.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Miyamoto Y,Takemori AEdoi
10.1016/0376-8716(93)80009-4subject
Has Abstractpub_date
1993-04-01 00:00:00pages
163-7issue
2eissn
0376-8716issn
1879-0046pii
0376-8716(93)80009-4journal_volume
32pub_type
杂志文章abstract：:Sequence of drug use was examined in a secondary analysis of two samples of serious drug users: one of 152 men and one of 133 women. The proportions of drug users following specified patterns of drug use onset were compared to proportions obtained in previous research in samples of high school youth, and serious drug ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(97)00032-x
更新日期：1997-05-02 00:00:00
abstract：BACKGROUND:The DSM specifies categorical criteria for psychiatric disorders. In contrast, a dimensional approach considers variability in symptom severity and can significantly improve statistical power. The current study tested whether a categorical, DSM-defined diagnosis of Alcohol Dependence (AD) was a better fit th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.12.020
更新日期：2014-03-01 00:00:00
abstract：:Although previous work suggests that juvenile onset bipolar disorder increases risk for substance use disorders and cigarette smoking, the literature on the subject is limited. We evaluated the association of risk for substance use disorders and cigarette smoking with bipolar disorder in adolescents in a case-control ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.12.016
更新日期：2008-06-01 00:00:00
abstract：:Studies on ethanol-exposed animals have revealed changes in anionic phospholipids in brain membranes. The intention of this study was to investigate whether there was a similar effect on man. Assuming platelets to be an adequate model for CNS synaptosomes, concentration and fatty acid composition of anionic phospholip...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(86)90065-7
更新日期：1986-02-01 00:00:00
abstract：:Ninety-two patients with alcoholism were interviewed on various aspects of alcohol use. Factor analysis of the data revealed five factors: withdrawal symptoms; help seeking behaviour; pathological drinking; legal difficulties; family problems. The analysis suggested the possibility of heterogenity in this clinical sam...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90037-9
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Smoking prevalence among those in substance misuse treatment remains much higher than the general population, despite evidence for effective cessation interventions that do not negatively impact substance misuse outcomes. This systematic review summarises qualitative data on barriers and facilitators to sm...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2017.07.043
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to test the hypothesis that desipramine would be an effective treatment in cocaine abusers with current depressive disorders. METHOD:This was a randomized, 12-week, double-blind, 'placebo-controlled trial of outpatients (N = 111) meeting DSM-III-R criteria for cocaine dependence and...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2005.03.026
更新日期：2005-11-01 00:00:00
abstract：:This preliminary report is the first demonstration of the acute effects of diacetylmorphine (heroin) administration on functional activation in the human brain using functional magnetic resonance imaging (fMRI). Four opiate addicts who received regular prescriptions for heroin, underwent fMRI using a visual activation...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(97)00140-3
更新日期：1997-12-01 00:00:00
abstract：:The present study describes an ultra-rapid opiate detoxification method using direct transition from heroin or methadone to oral naltrexone after deep sedation with oral midazolam in conjunction with ondansetron and clonidine treatment. Twenty patients were detoxified with the method. No serious events occurred, but t...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(98)00100-8
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Amphetamine abuse is increasing worldwide, and the occurrence of amphetamine-induced (AI) psychiatric issues further complicates treatment. In response, the DSM 5 has introduced the classification of amphetamine-induced obsessive-compulsive disorders (AI-OCD), though little has been published on either its p...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.12.034
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Substance use treatment is rarely a one-time event for individuals with substance use disorders. Sustained reductions in substance use and its related symptoms may result from multiple treatment episodes. METHODS:We use a marginal structural model with inverse-probability-of-treatment weighting to estimate ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.12.017
更新日期：2014-03-01 00:00:00
abstract：:Most evidence on the motives-alcohol use link has come from cross-sectional research using retrospective assessments. It remains also to be demonstrated whether motives predict drinking in particular circumstances. In the present study, drinking motives assessed 2 weeks prior to a diary study were used to predict the ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.02.021
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND/AIMS:Adolescents and young adults have the highest rates of opioid use, and despite shared risk-factors such as mental health and social pressures, there is little information on the relationship between education and opioid use disorder. In this study, we sought to assess differences in educational attainme...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107618
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Prenatal tobacco smoke exposure is associated with alterations in motivated behavior in offspring, such as increased consumption of highly palatable foods and abused drugs. Animal models show that gestational nicotine (GN) exposure mediates changes in responding for sucrose and drug reward. METHODS:A novel,...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.01.025
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:We sought to delineate patterns of poly-club-drug use among gay and bisexual men. Data were drawn from a large-scale 12-month longitudinal investigation of club drug use and sexual behavior among 450 racially, ethnically, and geographically diverse sample of gay and bisexual men in New York City. METHODS:Usi...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2006.12.028
更新日期：2007-07-10 00:00:00
abstract：:Individuals with co-occurring substance use and psychiatric disorders have a more severe clinical course and poorer outcomes than do individuals with one disorder. In an attempt to find intervening variables that may contribute to improvement in treatment outcomes among individuals with co-occurring disorders, we inve...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.01.009
更新日期：2007-07-10 00:00:00
abstract：:The differences in beliefs about the effects of anabolic steroid (AS) use between AS users and non-users provides potentially important clues to understanding AS use. Two groups of bodybuilders were used in this comparison: AS users (n = 20) and non-users (n = 27). Subjects completed a 40-item scale measuring their be...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(95)01211-7
更新日期：1996-03-01 00:00:00
abstract：PURPOSE:To study the relationship between drug use and adherence to highly active antiretroviral therapy (HAART) among HIV-positive people, with two alternative measures of drug use: a set of drug uses considered independent and patterns capturing combinations of drug uses. METHODS:A cross-sectional survey conducted a...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(06)80012-8
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Gender differences in the prevalence and characteristics of misuse of methamphetamine (meth) and prescription stimulants were examined in a representative US sample of youths and young adults aged 16-25 (N=24,409). METHODS:Stimulant misusers were categorized into three mutually exclusive subgroups: meth use...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2006.12.020
更新日期：2007-07-10 00:00:00
abstract：AIM:Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo. METHODS:This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 tr...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2009.04.015
更新日期：2009-09-01 00:00:00
abstract：:Prolactin (PRL) and thyrotropin (TSH) serum levels were determined in a group of young female heroin addicts treated in hospital with methadone in tapered doses. At admission, from 24 to 3 h after the last dose of 'street' heroin, basal PRL values were 21 +/- 2.6 ng/ml, i.e. significantly higher (P less than 0.001) th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(87)90034-2
更新日期：1987-11-30 00:00:00
abstract：BACKGROUND:With the emergence of illicit fentanyl, fentanyl-involved overdose rates increased from 2013 to 2017 in the United States (US). We describe US trends in opioid-related overdose mortality rates by race, age, urbanicity, and opioid type before and after the emergence of fentanyl. METHODS:Using the Centers for...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108321
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Alcohol protective behavioral strategies (PBS) have been proposed as mechanisms of change underlying interventions for reducing alcohol use and alcohol-related problems. Few studies have examined PBS use among non-college student populations and no study has examined PBS use among adult injured patients. The...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.drugalcdep.2019.06.037
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Little is known about the engagement of young people who use drugs (PWUD) in harm reduction programs (HRPs), and few studies have included non-opioid users and non-injectors. While HRPs have effectively engaged PWUD, young people are under-represented in their services. METHODS:The Injection Drug Users Heal...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.04.032
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Legalization of medical and recreational cannabis has coincided with an increase in novel forms of cannabis use and a burgeoning cannabis product industry. This research seeks to understand the occurrence of discussions about these emerging and traditional forms of use in an online social media discussion fo...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.03.041
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Previous studies found enlarged striatum and white matter in those with stimulants use disorders. Whether primarily ketamine users (Primarily-K) and ketamine users who co-used stimulants and other substances (K+PolyS) have abnormal brain volumes is unknown. This study aims to evaluate possible brain structur...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108063
更新日期：2020-05-25 00:00:00
abstract：BACKGROUND:Nicotine is commonly abused in adolescence and is believed to be a "gateway" to other drugs of abuse [e.g., methamphetamine (METH)]. The relationship between early nicotine exposure and later METH use is complicated because the majority of juvenile smokers continue to use cigarettes into adulthood. Thus, the...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.06.029
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Due largely to ambiguous or incomplete information provided on death certificates, the widely cited Multiple Cause of Death (MCOD) data reported by the U.S. Centers for Disease Control and Prevention has been shown to undercount the number of fatal overdoses caused by specific drugs. However, the extent of...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107807
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Benzodiazepine overdose rates have increased in the US, largely from concomitant use of other drugs such as opioids. Studies are needed to examine trends in prescription tranquilizer (e.g., benzodiazepine) use-with a particular focus on use of other drugs such as opioids-to continue to inform prevention effo...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.11.015
更新日期：2019-02-01 00:00:00
abstract：:Hazardous drinking is prevalent among college students, yet few seek treatment. Anxiety sensitivity AS is one factor with relevance to drinking. Yet, there are no known estimates of the prevalence of elevated AS among hazardous drinkers. The current study sought to estimate the prevalence of elevated AS among hazardou...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.107922
更新日期：2020-04-01 00:00:00
