Functional magnetic resonance imaging of the acute effect of intravenous heroin administration on visual activation in long-term heroin addicts: results from a feasibility study.

Abstract:

:This preliminary report is the first demonstration of the acute effects of diacetylmorphine (heroin) administration on functional activation in the human brain using functional magnetic resonance imaging (fMRI). Four opiate addicts who received regular prescriptions for heroin, underwent fMRI using a visual activation paradigm before and after a dose of 30 mg heroin. All four showed a decrease after the heroin dose in the extent of significant activation. This method shows promise for sequential scanning to determine brain activity in response to different drugs and routes of drug administration.

journal_name

Drug Alcohol Depend

authors

Sell LA,Simmons A,Lemmens GM,Williams SC,Brammer M,Strang J

doi

10.1016/s0376-8716(97)00140-3

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

55-60

issue

1

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(97)00140-3

journal_volume

49

pub_type

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