Abstract:
AIM:Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo. METHODS:This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 treatment-seekers randomized, having a diagnosis of cocaine dependence; 72 participants were randomized to placebo, 69 to modafinil 200mg, and 69 to modafinil 400mg, taken once daily on awakening. Participants came to the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy weekly. The primary outcome measure was the weekly percentage of cocaine non-use days. RESULTS:The GEE regression analysis showed that for the total sample, there was no significant difference between either modafinil group and placebo in the change in average weekly percent of cocaine non-use days over the 12-week treatment period (p>0.79). However, two secondary outcomes showed significant effects by modafinil 200mg: the maximum number of consecutive non-use days for cocaine (p=0.02), and a reduction in craving (p=0.04). Also, a post hoc analysis showed a significant effect of modafinil that increased the weekly percentage of non-use days in the subgroup of those cocaine patients who did not have a history of alcohol dependence (p<0.02). CONCLUSIONS:These data suggest that modafinil, in combination with individual behavioral therapy, was effective for increasing cocaine non-use days in participants without co-morbid alcohol dependence, and in reducing cocaine craving.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Anderson AL,Reid MS,Li SH,Holmes T,Shemanski L,Slee A,Smith EV,Kahn R,Chiang N,Vocci F,Ciraulo D,Dackis C,Roache JD,Salloum IM,Somoza E,Urschel HC 3rd,Elkashef AMdoi
10.1016/j.drugalcdep.2009.04.015subject
Has Abstractpub_date
2009-09-01 00:00:00pages
133-9issue
1-2eissn
0376-8716issn
1879-0046pii
S0376-8716(09)00156-2journal_volume
104pub_type
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journal_title:Drug and alcohol dependence
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abstract::A single dose of ethanol has been shown to affect both striatal and hippocampal high-affinity choline uptake. This effect is probably mediated through effects of ethanol on acetylcholine release. Choline uptake has also been shown to be altered in ethanol-dependent animals, and these effects may be coupled to alterat...
journal_title:Drug and alcohol dependence
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abstract:BACKGROUND:Persistence and emergence of ADHD in adulthood are associated with substance problems. We investigate differential implications of ADHD course for tobacco, alcohol, or marijuana problems by sex, then whether substance misuse results from ADHD or contributes to it, through a twin differences design. METHODS:...
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journal_title:Drug and alcohol dependence
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doi:10.1016/s0376-8716(99)00048-4
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章,多中心研究
doi:10.1016/j.drugalcdep.2006.11.005
更新日期:2007-05-11 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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journal_title:Drug and alcohol dependence
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