Human spinal fluid methadone levels.

Abstract:

:Cerebral spinal fluid (CSF) levels of methadone were measured in nine methadone maintenance patients requiring lumbar punctures for medical or surgical treatment. Concurrent serum methadone levels were also determined. The CSF concentration of methadone in all cases was a fraction of the corresponding serum level--ranging from 2 to 73%. The CSF concentrations of methadone ranged from 0.010 to 0.097 ng%. Peak methadone levels in CSF appeared approximately 3 - 8 hours after methadone administration.

journal_name

Drug Alcohol Depend

authors

Rubenstein RB,Kreek MJ,Mbawa N,Wolff WI,Korn R,Gutjahr CL

doi

10.1016/0376-8716(78)90022-4

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

103-6

issue

2

eissn

0376-8716

issn

1879-0046

pii

0376-8716(78)90022-4

journal_volume

3

pub_type

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