Abstract：
BACKGROUND:Amphetamine analogs have been demonstrated to have some efficacy in reducing use in cocaine dependent individuals. However, these agents also have potential for abuse. Lisdexamfetamine (LDX), a lysine+dextroamphetamine formulation, has been approved for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and as a prodrug, has less abuse potential. OBJECTIVE:This pilot study sought to evaluate the safety, tolerability, and efficacy of LDX as a candidate treatment for cocaine dependence. METHODS:A randomized, double-blind, placebo-controlled parallel group study served to evaluate LDX in 43 cocaine-dependent individuals: (1) placebo (PBO; 0mg, n=21), (2) LDX (70mg, n=22). Participants received medication for 14 weeks. Cocaine use was determined based on urine analysis for benzoylecgonine (BE; a cocaine metabolite). RESULTS:Retention rates were higher though not significantly different in the PBO (71.4%) than the LDX condition (57.1%). Compared to those in the PBO condition, those receiving LDX were more likely to report experiencing (ps<0.05) diarrhea (45.5% vs. 14.3%), headaches (45.5% vs. 9.5%), and anxiety (31.8% vs. 4.8%). No differences in medication conditions were observed for blood pressure, heart rate, or body weight. In the randomized sample, no differences in cocaine use were seen. Those receiving LDX reported significantly less craving for cocaine than participants receiving PBO. CONCLUSIONS:LDX did not significantly reduce cocaine use compared to PBO in the randomized sample.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Mooney ME,Herin DV,Specker S,Babb D,Levin FR,Grabowski Jdoi
10.1016/j.drugalcdep.2015.05.042subject
Has Abstractpub_date
2015-08-01 00:00:00pages
94-103eissn
0376-8716issn
1879-0046pii
S0376-8716(15)00296-3journal_volume
153pub_type
杂志文章,随机对照试验abstract：:The Wide Range Achievement Test (Revised) (WRAT-R) reading test, demographic variables and drug use severity were used to develop prediction equations to estimate premorbid ability in 92 cocaine abusers. WRAT-R reading was correlated significantly with full scale, verbal and performance IQ. Stepwise regression indicat...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(95)01191-9
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:A cascade of care framework has been proposed to identify and address implementation gaps in addiction medicine. Using this framework, we characterized temporal trends in engagement in care for opioid use disorder (OUD) in Vancouver, Canada. METHODS:Using data from two cohorts of people who use drugs, we as...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.04.026
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abstract：BACKGROUND:In India, heterosexual transmission accounts for approximately 80% of the spread of HIV, the virus that causes AIDS. Male alcohol use and its putative association with sexual risk are explored to inform HIV prevention interventions. METHODS:A survey of 1196 male patrons of wine shops or bars was conducted f...
journal_title：Drug and alcohol dependence
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doi：10.1016/j.drugalcdep.2007.11.016
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abstract：BACKGROUND:Surgical ablation of select brain areas has been frequently used to alleviate psychological dependence on opiate drugs in certain countries. However, ablative brain surgery was stopped in China in 2004 due to the related ethical controversy and possible side effects. Deep brain stimulation (DBS), a less inva...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.09.012
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abstract：BACKGROUND:The current review examined recent literature to determine our state of knowledge about the potential ability of physical activity serve as a protectant against drug abuse vulnerability. METHODS:Both preclinical and clinical studies were examined using either associational or random assignment study designs...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
doi：10.1016/j.drugalcdep.2015.05.037
更新日期：2015-08-01 00:00:00
abstract：AIMS:To develop an Opioid Overdose Knowledge Scale (OOKS) and an Opioid Overdose Attitudes Scale (OOAS) to evaluate take-home naloxone training. METHODS:Psychometric instrument development study conducted in England using convenience samples. Forty-five items were selected for the OOKS organised in four sub-scales (ri...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.02.007
更新日期：2013-09-01 00:00:00
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journal_title：Drug and alcohol dependence
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abstract：:A statistical analysis of the MAST scores obtained by its administration to industrial workers, hospitalized alcoholics and persons arrested driving while intoxicated has been performed. The author discusses the modalities and possibilities of improving the test reliability which will increase its efficiency in the sc...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90064-1
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:This study seeks to identify changes in perceived barriers to alcohol treatment and predictors of treatment use between 1991-92 and 2001-02, to potentially help understand reported reductions in treatment use at this time. Social, economic, and health trends during these 10 years provide a context for the st...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.01.005
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abstract：BACKGROUND:An emerging area of preclinical research has investigated whether drug use in parents prior to conception influences drug responsivity in their offspring. The present work sought to further characterize such effects with cannabis by examining whether a parental THC history modified locomotor sensitization to...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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abstract：BACKGROUND:We report prevalence and incidence of drug use initiation in Australian gay and bisexual men (GBM) participating in an online cohort study. METHODS:Between September 2014 and June 2015, 1,710 GBM were enrolled in the Following Lives Undergoing Change Study and followed-up six monthly. Participants were aske...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.04.009
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Binge drinking (BD) consists of heavy episodic alcohol use. Whereas the World Health Organization (WHO) defines BD as 60g of alcohol or more per occasion, the National Institute on Alcoholism and Alcohol Abuse (NIAAA) conceives BD as drinking 70g (men) or 56g (women) in less than two hours. We compared the s...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究
doi：10.1016/j.drugalcdep.2017.01.034
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:Recent research has called upon investigators to exploit cross-national differences to uncover the cultural and structural factors influencing drug use. While the individual-level correlates are well-established, little is known about the association between cross-national variation in drug policies and yo...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2012.12.012
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:E-cigarette use is rapidly increasing, especially among youth and young adults. We need to learn what factors are associated with uptake in e-cigarettes. One important set of predictors is beliefs about e-cigarettes' potential harms and benefits. METHODS:Online survey data were collected in July, 2014 fro...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2015.11.003
更新日期：2016-01-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.06.009
更新日期：2016-08-01 00:00:00
abstract：:The role that male sexual partners play in the treatment outcome of drug dependent pregnant women deserves greater attention. Pregnant women enrolled in a comprehensive treatment program with drug-free (n=85) or drug-using (n=82) male sexual partners completed a relationship survey and were compared on partner and psy...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(03)00030-9
更新日期：2003-06-05 00:00:00
abstract：BACKGROUND:The DSM specifies categorical criteria for psychiatric disorders. In contrast, a dimensional approach considers variability in symptom severity and can significantly improve statistical power. The current study tested whether a categorical, DSM-defined diagnosis of Alcohol Dependence (AD) was a better fit th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.12.020
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:The opioid crisis has led to an increased number of pregnant opioid-dependent women receiving opioid-maintenance therapy (e.g. buprenorphine, BUP), but little is known about the consequences of gestational BUP exposure on pregnancy outcomes, maternal care, or offspring development. METHODS:Our translational...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107625
更新日期：2019-12-01 00:00:00
abstract：:In this paper we estimate the risk of becoming cannabis dependent within 24 months after first use of cannabis and examine subgroup variation in this risk. The study estimates are based on the National Household Survey on Drug Abuse conducted during 2000-2001, with a representative sample of U.S. residents ages 12 and...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2004.11.014
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.03.021
更新日期：2011-11-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.03.015
更新日期：2016-06-01 00:00:00
abstract：:In this paper, we examine the effects of age at first substance use, and history of psychiatric disorders, on the development of substance use disorder (SUD) by age 16. We use a prospective, longitudinal design to disaggregate the effects of age at first use and time since first use on the development of adolescent SU...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2004.03.013
更新日期：2004-09-06 00:00:00
abstract：:Research over the past 10 years has suggested that methamphetamine use has become a significant problem and is associated with risky sexual behaviors among gay and bisexual men. In order to better understand initiation into methamphetamine use among gay and bisexual men, qualitative analyses were performed on a sample...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2007.02.017
更新日期：2007-10-08 00:00:00
abstract：BACKGROUND:Opioid use and abuse in the United States continues to expand at an alarming rate. In this study, we examine the county-level determinants of the availability and abuse of prescription opioids to better understand the socio-ecological context, and in particular the role of the healthcare delivery system, on ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.03.002
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:We measured associations between parental incarceration and STI/HIV-related drug use and sex risk, assessing differences by race, age at first parental incarceration, and potential mediators of the relationship. METHODS:We used Waves I (adolescence), III (young adulthood), and IV (adulthood) of the National...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.11.006
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2006.03.002
更新日期：2006-09-15 00:00:00
abstract：OBJECTIVE:Flavored e-cigarette use has risen rapidly, especially among young adults who also smoke cigarettes. We sought to determine whether flavoring enhances the subjective rewarding value, relative reinforcing value, and absolute reinforcing value of an e-cigarette with nicotine compared to an unflavored e-cigarett...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.06.030
更新日期：2016-09-01 00:00:00
abstract：:Previous studies have demonstrated that administration of nonspecific opioid antagonists such as naltrexone or naloxone reduces ethanol-induced locomotor activity in mice. However, because of their broad pharmacological profile, it remains unclear through which opioid receptor this antagonism is achieved. Therefore, t...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2004.11.007
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Prior research shows that cannabis use during treatment for Alcohol Use Disorders (AUD) is related to fewer abstinent days from alcohol, although only among those who use cannabis 1-2x/month. Here we extend prior research by assessing the relationship between the frequency of cannabis use during AUD treatmen...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.drugalcdep.2018.08.020
更新日期：2018-12-01 00:00:00
abstract：:The differences in beliefs about the effects of anabolic steroid (AS) use between AS users and non-users provides potentially important clues to understanding AS use. Two groups of bodybuilders were used in this comparison: AS users (n = 20) and non-users (n = 27). Subjects completed a 40-item scale measuring their be...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(95)01211-7
更新日期：1996-03-01 00:00:00
