Abstract:
BACKGROUND:The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. METHODS:We performed a cross-sectional case-control study. The study group was made of 220 women. Of these, 85 were alcoholic (27 without liver disease and 58 with alcoholic liver disease) and 135 were non-alcoholic (42 healthy controls and 93 with liver disease unrelated to alcohol). Genotyping of alcohol-metabolizing enzymes was performed using PCR-RFLP methods. RESULTS:The distribution of the allelic variants (alleles 1 and 2) in the whole subjects analyzed was: ADH1B 91.6% and 8.4%; ADH1C 58.4% and 41.6%; CYP2E1 Dra-I 15% and 85%; CYP2E1 Pst-I 96.8% and 3.2%; and ALDH2 100% and 0%, respectively. Carriage of genotypes containing the ADH1B*2 mutant allele significantly protected against alcoholism [odds-ratio (OR)=0.00; 95% confidence interval (95% CI): 0.00-0.94; p=0.02] but was associated with an increased risk for alcoholic liver disease among alcohol-dependent women [OR=0.43; 95% CI: 0.18-0.41; p=0.004]. Analysis of the remaining loci showed no significant associations. CONCLUSIONS:In Caucasian Spanish women the ADH1B*2 allele modulates the risk for alcohol dependence and for alcoholic liver disease. Given the small number of alcoholic women analyzed here, these data need further validation in larger cohorts.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Lorenzo A,Auguet T,Vidal F,Broch M,Olona M,Gutiérrez C,López-Dupla M,Sirvent JJ,Quer JC,Santos M,Richart Cdoi
10.1016/j.drugalcdep.2006.03.002subject
Has Abstractpub_date
2006-09-15 00:00:00pages
195-200issue
2eissn
0376-8716issn
1879-0046pii
S0376-8716(06)00072-Xjournal_volume
84pub_type
杂志文章abstract:INTRODUCTION:"Dabbing" involves heating extremely concentrated forms of marijuana to high temperatures and inhaling the resulting vapor. We studied themes describing the consequences of using highly concentrated marijuana by examining the dabbing-related content on Twitter. METHODS:Tweets containing dabbing-related ke...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.06.034
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:It has been proposed that relapse vulnerability in previously dependent individuals results from augmentation of drug-induced reinforcement due to repeated associations between the interoceptive properties of the drug and reduction of acute withdrawal distress. METHODS:To test this hypothesis, male Sprague-...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2014.01.007
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To determine HIV prevalence and potential associations with sociodemographic and behavioral factors among injection drug users (IDUs) in Tashkent, Uzbekistan. METHODS:Subjects in this cross-sectional study provided sociodemographic and risk behavior data and were tested for HIV antibody with a saliva-based ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(06)80003-7
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Kratom (Mitragyna speciosa Korth.) has been used in Southeast Asia for hundreds of years to increase energy, for relaxation, and to diminish opioid withdrawal. Kratom use has recently spread to Western countries. Kratom could potentially be used for the treatment of opioid withdrawal and pain, but more insig...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2020.108235
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Flavored e-cigarette use has risen rapidly, especially among young adults who also smoke cigarettes. We sought to determine whether flavoring enhances the subjective rewarding value, relative reinforcing value, and absolute reinforcing value of an e-cigarette with nicotine compared to an unflavored e-cigarett...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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abstract:BACKGROUND:Substance use treatment is rarely a one-time event for individuals with substance use disorders. Sustained reductions in substance use and its related symptoms may result from multiple treatment episodes. METHODS:We use a marginal structural model with inverse-probability-of-treatment weighting to estimate ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2013.12.017
更新日期:2014-03-01 00:00:00
abstract::This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol-o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found during the first 3 days ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(83)90056-x
更新日期:1983-08-01 00:00:00
abstract::The aim of the present study is to analyze whether the addition of propylthiouracil reverts the influence of ethanol on the development of periportal and pericentral hepatocytes and their nuclei in male albino mice. Propylthiouracil-treated animals showed decreased cellular and nuclear areas when compared with the con...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(88)90004-x
更新日期:1988-02-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:2003-11-24 00:00:00
abstract::The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these recept...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1979-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2019.04.019
更新日期:2019-08-01 00:00:00
abstract::Opioid receptor agonists can modulate the activity of dopamine neurons and could therefore, modify the behavioral effects of drugs that act through the dopamine systems, such as d-amphetamine and cocaine. We tested the ability of agonists selective for the mu- (morphine, methadone, buprenorphine, nalbuphine and heroin...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00129-4
更新日期:1997-12-15 00:00:00
abstract::Cocaine-induced kindling, which has been hypothesized to underlie cocaine-induced craving, is reversed by carbamazepine treatment. Though preliminary studies showed carbamazepine to be useful for relapse prevention in cocaine-dependent subjects, more recent studies have failed to replicate those findings. We conducted...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-06-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(97)00111-7
更新日期:1997-11-25 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(81)90103-4
更新日期:1981-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2012.02.022
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Contingency management (CM) is an efficacious intervention for reducing cigarette smoking. However, CM is rarely adopted as a smoking cessation treatment in the community. This study analyzed the effectiveness of a CM procedure in combination with a cognitive-behavioral treatment (CBT) for smoking cessation ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.drugalcdep.2014.03.030
更新日期:2014-07-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(84)90027-9
更新日期:1984-01-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.07.003
更新日期:2016-09-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2016.12.027
更新日期:2017-04-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.02.006
更新日期:2015-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/0376-8716(94)90115-5
更新日期:1994-04-01 00:00:00
abstract::We aimed to study the prevalence patterns and course of benzodiazepine (BZD) abuse in an Israeli methadone maintenance (MMT) clinic using repeated random observed urine analysis as well as self-report data. Lifetime and current prevalence of BZD abuse were found in 66.3 and 50.8% patients, respectively. It was found t...
journal_title:Drug and alcohol dependence
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0376-8716(98)00175-6
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Individuals with a family history of alcoholism are at much greater risk for developing an alcohol use disorder (AUD) than youth or adults without such history. A large body of research suggests that there are premorbid differences in brain structure and function in family history positive (FHP) individuals ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章,评审
doi:10.1016/j.drugalcdep.2015.10.021
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Heavy drinkers are at high risk for suicide attempt and suicide. Multiple factors, when examined in isolation, have been implicated in the risk of suicide attempt in this population. In this report, we present a comprehensive model of the 3-year risk of suicide attempt in heavy drinkers using a longitudinal ...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2018.01.010
更新日期:2018-05-01 00:00:00
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journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2015.02.035
更新日期:2015-08-01 00:00:00
abstract::This paper documents the bifurcation of the market for commercial marijuana from the market for designer marijuana in New York City. Commercial marijuana is usually grown outdoors, imported to NYC, and of average quality. By contrast, several varities of designer marijuana are usually grown indoors from specially bred...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/j.drugalcdep.2006.09.013
更新日期:2007-09-01 00:00:00
abstract::Inhalant abuse has existed for a considerable period of time and it is currently one of the most prevalent drug abuse problems in the world. One repercussion from using these compounds is that abuse may result in lethality. In an attempt to better understand the deaths associated with inhalant abuse, the authors surve...
journal_title:Drug and alcohol dependence
pub_type: 杂志文章
doi:10.1016/s0376-8716(98)00139-2
更新日期:1999-02-01 00:00:00