Abstract：
:Research has identified children of alcoholics (COAs) as a population at increased risk for developing substance use problems. Genetic studies support the Al allele of the D2 dopamine receptor gene (DRD2) as a risk marker for alcoholism and substance use disorders. In this study, substance use was assessed in 48 adolescent boys of alcoholics with the DRDR A1(+) allele (A1A1/A1A2 genotypes) or the A1(-) allele (A2A2 genotype). The results revealed that boys with the A1(+) allele tried (p=0.0001) and got intoxicated on alcohol more often (p=0.009) than boys with the A1(-) allele. Boys with the A1(+) allele tried more (p=0.004) and used more substances overall (p=0.008) than boys with the A1(-) allele. Boys with the A1(+) allele developed a tobacco habit more often (p=0.03) and experienced marijuana high at an earlier age (p=0.001) than boys with the A1(-) allele. The best predictors of substance use severity in boys with the A1(+) allele were Psychoticism (p=0.01) and Negative Affect (p=0.04). The results provide support for the DRD2 A1 allele as a marker identifying a subgroup of COAs at high risk for developing substance use problems.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Conner BT,Noble EP,Berman SM,Ozkaragoz T,Ritchie T,Antolin T,Sheen Cdoi
10.1016/j.drugalcdep.2005.03.005keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
379-87issue
3eissn
0376-8716issn
1879-0046pii
S0376-8716(05)00089-Xjournal_volume
79pub_type
杂志文章abstract：:The purpose of this cross-sectional study was to classify a sample of HIV-seropositive African-American crack cocaine smokers into homogenous HIV drug use and sexual risk groups using a two step multivariate cluster analysis. Two hundred and fifty-eight crack cocaine smokers participated in the study. Cluster analysis...
journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-03-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2002-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2015-08-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：1991-05-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-07-01 00:00:00
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journal_title：Drug and alcohol dependence
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2008.04.005
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2010-06-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,评审
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更新日期：2010-02-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 临床试验,杂志文章
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更新日期：2001-07-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
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更新日期：2016-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-10-01 00:00:00
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journal_title：Drug and alcohol dependence
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更新日期：2017-09-01 00:00:00
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更新日期：2018-08-01 00:00:00
