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Sex differences in drug use among polysubstance users.

Abstract：

BACKGROUND:Available evidence indicates women with substance use disorders may experience more rapid progression through usage milestones (telescoping). The few investigations of sex differences in treatment-seeking populations often focus on single substances and typically do not account for significant polysubstance abuse. The current study examined sex differences in a heterogeneous sample of treatment seeking polysubstance users. We examined patterns of drug use, age at drug use milestones (e.g., initial use, regular use), and progression rates between milestones. Nicotine and alcohol use were also evaluated. METHODS:Participants (n = 543; 288 women) completed personal histories of substance use, including chronicity, frequency, and regularity, as well as inventories assessing affect, and intellectual ability. RESULTS:Rates of drug use and milestone ages varied by sex and specific drug. Analyses suggested pronounced telescoping effects for pain medication and marijuana, with women progressing more rapidly through usage milestones. CONCLUSIONS:Our data were generally supportive of telescoping effects, although considerable variance in progression measures was noted. The contrast between the marked telescoping observed in pain medication use and the absence of telescoping in other opioids was of particular interest. The discrepancy in telescoping effects, despite shared pharmacologies, suggests the need for further work examining underlying psychosocial factors. These results highlight that the specific sample population, substance, and outcome measure should be carefully considered when interpreting sex differences in substance use.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Lewis B,Hoffman LA,Nixon SJ

doi

10.1016/j.drugalcdep.2014.10.003

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

127-33

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(14)01848-1

journal_volume

145

pub_type

杂志文章

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