Abstract：
BACKGROUND:Previous cross-sectional MRI studies with healthy, young-to-middle-aged adults reported no significant differences between smokers and non-smokers on total hippocampal volume. However, these studies did not specifically test for greater age-related volume loss in the total hippocampus or hippocampal subregions in smokers, and did they did not examine relationships between hippocampal and subfield volumes and episodic learning and memory performance. METHODS:Healthy, young-to-middle-aged (45 ± 12 years of age) smokers (n=39) and non-smokers (n=43) were compared on total hippocampal and subfield volumes derived from high-resolution 4 Tesla MRI, emphasizing testing for greater age-related volume losses in smokers. Associations between hippocampal volumes and measures of episodic learning and memory were examined. RESULTS:Smokers showed significantly smaller volumes, as well as greater volume loss with increasing age than non-smokers in the bilateral total hippocampus and multiple subfields. In smokers, greater pack-years were associated with smaller volumes of the total hippocampus, presubiculum, and subiculum. In the entire cohort, performance on measures of learning and memory was related to larger total hippocampal and several subfield volumes, predominately in the left hemisphere. CONCLUSIONS:Chronic cigarette smoking in this young-to-middle aged cohort was associated with smaller total hippocampal and subfield volumes, which were exacerbated by advancing age. Findings also indicated an adverse smoking dose/duration response (i.e., pack-years) with total hippocampal and select subfield volumes. These hippocampal volume abnormalities in smokers may be related to the deficiencies in episodic learning and memory in young-to-middle-aged smokers reported in previous studies.
journal_name
Drug Alcohol Dependjournal_title
Drug and alcohol dependenceauthors
Durazzo TC,Meyerhoff DJ,Nixon SJdoi
10.1016/j.drugalcdep.2013.08.020subject
Has Abstractpub_date
2013-12-01 00:00:00pages
704-11issue
2eissn
0376-8716issn
1879-0046pii
S0376-8716(13)00336-0journal_volume
133pub_type
杂志文章abstract：:Using a 'snowballing' technique, prospective data have been collected from 135 regular drug using individuals in two Scottish towns, Edinburgh, and Ayr. Data from the first wave would suggest that poly drug use is common, with a major reliance on licit, prescribed substances. Amongst both intravenous and non-intraveno...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90013-6
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Approximately 700,000 Social Security beneficiaries in the U.S. with psychiatric disabilities have been assigned a representative payee to manage their funds but it is unclear how those judged to need a payee differ from others and whether payee assignment improves clinical outcomes, especially substance abu...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2006.05.026
更新日期：2007-01-12 00:00:00
abstract：BACKGROUND:In laboratory animals, augmentation of GABA neurotransmission results in inhibition of cocaine self-administration and inhibition of reinstatement to cocaine-seeking behaviors. If parallel effects were observed in humans, GABA-ergic medication should be effective both in the abstinence-induction as well as i...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.drugalcdep.2005.07.009
更新日期：2006-02-28 00:00:00
abstract：BACKGROUND:The purpose of this study was to identify distinct classes of college students on the basis of recent and past drinking behaviors and evaluate how implicit and explicit measures of drinking identity predict membership in these classes. METHODS:US undergraduate students (N=456) completed online implicit (Imp...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.06.010
更新日期：2017-09-01 00:00:00
abstract：:Chronic alcoholic liver disease is associated with several immunological alterations: depressed T-cell function, low serum gamma-interferon, and high serum tumour necrosis factor (TNF-alpha) and interleukin levels. Therefore, macrophage activity seems to be enhanced. Some cytokines, such as TNF-alpha, exert adverse ef...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(95)01130-q
更新日期：1995-07-01 00:00:00
abstract：AIMS:Worldwide, alcohol use disorder (AUD) is one of the most common substance use disorders, yet often goes undertreated. One major barrier that prevents adequate treatment of AUD is the high stigmatization the disorder receives, including from the scientific community. Thus, we evaluated the current use of patient-ce...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108209
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:It is assumed that recreational use of methamphetamine can trigger acute myocardial infarction (AMI) events, but estimates of longitudinal hazards of AMI among methamphetamine users are lacking. METHODS:Retrospective cohort study: Competing-risks analysis was used to estimate time-to-AMI patterns in methamp...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.03.030
更新日期：2018-07-01 00:00:00
abstract：:Under the guidance of experts, 120 secondary school students from three wine-producing and three other areas of France discussed their experience with alcohol; assessed the value of materials used in primary prevention programmes; produced themselves such materials and evaluated the impact of the different approaches....
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(90)90164-a
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:Alcohol use-particularly unhealthy alcohol use-exacerbates risks associated with Hepatitis C virus (HCV). However, whether unhealthy alcohol use is appropriately addressed among HCV+ patients is understudied. We examined receipt of alcohol-related care among HCV+ patients and unhealthy alcohol use. METHODS:...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.03.047
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:In recent decades, smoking has become an increasingly non-normative behavior. Because deviant behaviors are associated with greater clinical and genetic risks, current-generation smokers may have greater concentrations of psychiatric comorbidity than previous generations. We examined this question empiricall...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2013.08.025
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Marijuana and tobacco are the substances used most commonly by adolescents and co-occurring use is common. Use of one substance may potentiate the addictive properties of the other. The current study examined the severity of nicotine addiction among teen smokers as a function of co-occurring marijuana use. ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.05.015
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Pain clinic laws are designed to cease or modify high-risk prescribing behavior. However, prior evaluations have not differentiated between these types of prescriber responses in their analysis, even though they may have different implications for patients. The purpose of this analysis is to investigate the ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2019.107591
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Ketamine abuse causes cognitive impairments, which negatively impact on users' abstinence, prognosis, and quality of life. RESULTS:of cognitive impairments in chronic ketamine users have been inconsistent across studies, possibly due to the small sample sizes and the confounding effects of concomitant use o...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2018.01.007
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Alcohol abuse and dependence can be disabling disorders, but accurate information is lacking on the prevalence of current DSM-IV alcohol abuse and dependence and how this has changed over the past decade. The purpose of this study was to present nationally representative data on the prevalence of 12-month DS...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2004.02.004
更新日期：2004-06-11 00:00:00
abstract：:This study examined the influence of education on smoking status in a cohort (n=316) of pregnant women who were smokers at the time they learned of the current pregnancy. Subjects were participants in clinical trials examining the efficacy of monetary-based incentives for smoking-cessation and relapse prevention. In m...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.drugalcdep.2009.03.013
更新日期：2009-10-01 00:00:00
abstract：AIMS:This study aimed at examining a possible association between cannabis use in adolescence and future disability pension (DP). DP can be granted to any person in Sweden aged 16-65 years if working capacity is judged to be permanently reduced due to long-standing illness or injury. METHODS:Data were obtained from a ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.07.038
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Electronic cigarettes (ECIGs) aerosolize liquids often containing flavorants for inhalation. Few studies have examined the role of flavors in ECIG use. This study's purpose was to examine reasons for flavored ECIG use using a mixed-method approach, concept mapping (CM). METHODS:Forty-six past 30-day adult E...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.07.007
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Methamphetamine has become one of the most widely used illicit substances in the world. We measured the prevalence and identified the correlates of methamphetamine use amongst current injection drug users (IDUs) in a China-Myanmar border region. METHODS:A cross-sectional survey including interviews and sero...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2014.01.021
更新日期：2014-05-01 00:00:00
abstract：AIM:To investigate the association between socio-demographic characteristics and alcohol consumption in India. METHODS:Analytical data were derived from household surveys conducted by the study team that included 6088 adults in five states of India (male = 3803, female = 2285). The sample was a cross-sectional selecte...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2017.12.024
更新日期：2018-04-01 00:00:00
abstract：:The authors performed pulmonary function tests on 10 chronic cocaine freebase smokers. Testing occurred at least 2 weeks after stopping cocaine use. Mean single breath carbon monoxide diffusing capacity (DLCOSB) was significantly reduced (P less than 0.05) in the cocaine smokers when compared with a control group of n...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(87)90047-0
更新日期：1987-05-01 00:00:00
abstract：:Frequency of drug access greatly affects the pattern and stability of cocaine self-administration. Previous research has shown that restricted drug availability produces remarkably consistent levels of daily cocaine intake, whereas increased or unlimited access produces more variable patterns of self-administration th...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00083-2
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:This study presents an integrative data analysis of the association between frequency of cannabis use and severity of depressive symptoms using data from four Australasian cohort studies. The integrated data comprised observations on over 6900 individuals studied on up to seven occasions between adolescence ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2012.06.002
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:A number of studies have researched the association between monoamine oxidase gene (MAO) polymorphisms and smoking behavior, but the conclusion is quite inconsistent. A meta-analysis was conducted to assess the association of MAO-A C1460T, MAO-A VNTR and MAO-B G644A polymorphisms with smoking behavior. METH...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章,meta分析
doi：10.1016/j.drugalcdep.2015.05.024
更新日期：2015-08-01 00:00:00
abstract：AIMS:1) To confirm the association between delay for assessment (DFA) and probability of first-time attendance in outpatient substance use disorder (SUD) treatment. 2) To evaluate whether this association varies by the type of primary substance for which the assessment was requested. 3) To assess the possibility of est...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.07.012
更新日期：2016-09-01 00:00:00
abstract：:A statistical analysis of the MAST scores obtained by its administration to industrial workers, hospitalized alcoholics and persons arrested driving while intoxicated has been performed. The author discusses the modalities and possibilities of improving the test reliability which will increase its efficiency in the sc...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/0376-8716(89)90064-1
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Although attentional bias to alcohol-related stimuli has been identified as a potentially important factor in initiating a drinking episode, little is known about whether it persists once drinking has begun. Chief among the measures of attentional bias is the visual probe task, which requires the ability to ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2011.01.016
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:In Chile, concerns mount about escalating cannabis use. Thus, it is important to have tools for early identification of at-risk users. The Cannabis Use Problems Identification Test (CUPIT) is a useful screening tool, and the aim of this study was to examine the psychometric properties of its Spanish version ...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2016.10.032
更新日期：2017-01-01 00:00:00
abstract：:The goal of this study was to determine the contribution of substance abuse to the expression of suicidal ideation in a sample of patients referred for evaluation of chemical dependency in a large urban Psychiatric Emergency Service (PES). Records from 777 consecutive patients referred to the chemical dependency servi...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/s0376-8716(02)00337-x
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Previous studies found enlarged striatum and white matter in those with stimulants use disorders. Whether primarily ketamine users (Primarily-K) and ketamine users who co-used stimulants and other substances (K+PolyS) have abnormal brain volumes is unknown. This study aims to evaluate possible brain structur...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2020.108063
更新日期：2020-05-25 00:00:00
abstract：BACKGROUND:Research on the relation of stress to alcohol consumption is inconsistent regarding the direction of effects, and this association has been shown to vary by sex and type of stress. We sought to build upon the stress-drinking literature by examining the direction of the stress-drinking association over time a...
journal_title：Drug and alcohol dependence
pub_type： 杂志文章
doi：10.1016/j.drugalcdep.2010.10.022
更新日期：2011-06-01 00:00:00
