当前位置： SCI文献检索 > DRUG AND ALCOHOL DEPENDENCE期刊下所有文献 > Smoking and psychopathology increasingly associated in recent birth cohorts.

Smoking and psychopathology increasingly associated in recent birth cohorts.

Abstract：

BACKGROUND:In recent decades, smoking has become an increasingly non-normative behavior. Because deviant behaviors are associated with greater clinical and genetic risks, current-generation smokers may have greater concentrations of psychiatric comorbidity than previous generations. We examined this question empirically by testing whether associations between measures of smoking, psychiatric diagnoses, and risk-associated personality traits, increased across seven birth-cohorts of the 20th century. METHOD:4326 subjects from a cross-sectional NIMH control sample were categorized into one of seven groups based on birth (born before 1930, and 1930s-80s) and one of three smoking levels (lifetime dependent smoker, never dependent smoker, never smoker). Smoking and ND were assessed using the Fagerstrom Test for Nicotine Dependence; psychiatric diagnoses (drug and alcohol dependence, major depression, and generalized anxiety disorder) using the Composite International Diagnostic Interview-Short Form, and personality traits (neuroticism and extraversion) with the Eysenck Personality Questionnaire. RESULT:Lifetime prevalence of smoking decreased across the seven cohorts. Associations between smoking and drug dependence, generalized anxiety, and neuroticism, as well as total psychiatric comorbidity, were greater in more recent cohorts [smoking-by-cohort interaction: p<0.01], with greatest increases contributed by nicotine-dependent smokers. Smoking was also independently associated with alcohol dependence and depression, but these associations did not significantly vary across cohorts. CONCLUSIONS:More recent generations included fewer persons who smoked, but their smoking was associated with greater psychiatric morbidity. Failure to account for systematic variation in comorbidity across smoking cohorts may lead to unwanted heterogeneity in clinical, and possibly genetic, studies of nicotine dependence.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Talati A,Wickramaratne PJ,Keyes KM,Hasin DS,Levin FR,Weissman MM

doi

10.1016/j.drugalcdep.2013.08.025

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

724-32

issue

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(13)00341-4

journal_volume

133

pub_type

杂志文章

在线工具

Smoking and psychopathology increasingly associated in recent birth cohorts.